A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A
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概要
- 論文の詳細を見る
In the present study, we investigated the transport of nephrotoxic mycotoxin ochratoxin A (OTxA) by a novel human organic anion transporter hNPT4 using the Xenopus oocyte expression system. hNPT4 mediated time- and concentration-dependent uptake of OTxA (Km: 802.8 μM) in a pH- and voltage-sensitive manner. Cis-inhibition experiments suggest that the substrate selectivity of hNPT4 is similar to that of hOAT4. The fact that the Km of OTxA for the efflux transporter hNPT4 was much higher than those for the uptake transporters hOAT1 and hOAT3 may favor the accumulation of OTxA in the tubular cell and lead to nephrotoxicity.
著者
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安西 尚彦
杏林大学医学部薬理学教室
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Jutabha Promsuk
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Jutabha Promsuk
杏林大学 医学部薬理学
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Endou Hitoshi
Department Of Pharmacology & Toxicology Kyorin University School Of Medicine
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Uchida Kohsuke
Department Of Pharmacology Dokkyo Medical University
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Sakurai Hiroyuki
Department Of Hepatobiliary Pancreatic And Transplant Surgery Graduate School Of Medicine Mie Univer
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Anzai Naohiko
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Hayashi Keitaro
Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan
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Domae Mariko
Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan
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Sakurai Hiroyuki
Department Of Biological & Chemical Engineering Gunma University
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Domae Mariko
Department Of Pharmacology And Toxicology Dokkyo Medical University School Of Medicine
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Hayashi Keitaro
Department Of Pharmacology And Toxicology Dokkyo Medical University School Of Medicine
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