Differential Expression of System L Amino Acid Transporters during Wound Healing Process in the Skin of Young and Old Rats(Molecular and Cell Biology)
スポンサーリンク
概要
- 論文の詳細を見る
In order to elucidate the role of the system L-type amino acid transporters (LATs) in the wound healing process of aged and young subjects, we investigated the expression of LAT1, LAT2 and their subunit 4F2hc in the skin healing process after artificial wounds of dorsal skin in the young and old rats. Methods: The 1 cm full-thickness incisional wounds were made through the skin and panniculus carnosus muscle. The wounds were harvested at days 1, 3, 5 and 7 post-wounding, the experimental controls were harvested the skin of rat without wounds and the various analyses were performed. Results: In young rats, gradually and noticeable wound healing was detected, however, in old rats, wound healing was found to be greatly delayed. In young rats, the expression of LAT1 was increased rapidly on the day 1 after wound induction, on the other hand, in old rats, the expression of LAT1 after wound induction was not different from the control group. In young rats, the expression of LAT2 after the induction of wound was not different from the control group, however in old rats, the expression of LAT2 on the day 1 of wound induction was rapidly elevated. Conclusion: These results suggest that the LAT1 and LAT2 increase in the wound healing process after cell injury in young and old rats, respectively.
- 2008-03-01
著者
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Endou Hitoshi
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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Kim Do
杏林大学 医学部薬理学
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Kim Do-kyung
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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KANAI Yoshikatsu
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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Endou Hitoshi
群馬大学 医学系研究科病態制御内科学
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Endou Hitoshi
杏林大学 医学部薬理学教室
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Kim Chun
Oral Biology Research Institute And The Second Stage Of Bk21 Chosun University College Of Dentistry
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Endou H
Kyorin Univ. School Of Medicine Tokyo Jpn
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Jeong Moon-jin
Oral Biology Research Institute And The Second Stage Of Bk21 Chosun University College Of Dentistry
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Kim Heung-Joong
Oral Biology Research Institute, Chosun University School of Dentistry
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Park Joo-Cheol
Department of Oral Histology and Developmental Biology, Seoul National University School of Dentistr
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Kim Do
Oral Biology Research Institute, Chosun University School of Dentistry
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KO Yeong
Oral Biology Research Institute and The second stage of BK21, Chosun University College of Dentistry
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PARK Kyung
Oral Biology Research Institute and The second stage of BK21, Chosun University College of Dentistry
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JEONG Soon-Jeong
Oral Biology Research Institute and The second stage of BK21, Chosun University College of Dentistry
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LIM Do-Seon
Department of Dental Hygiene, College of Health Science, Eulji University
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Kim Heung-joong
Oral Biology Research Institute And The Second Stage Of Bk21 Chosun University College Of Dentistry
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Kanai Yoshikatsu
Department Of Pharmacology & Toxicology Kyorin University School Of Medicine
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Kanai Yoshikatsu
Department Of Pharmacol. Toxicol. Kyorin Univ.
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Endou Hitoshi
Department Of Pharmacology & Toxicology Kyorin University School Of Medicine
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Kim Do
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Lim Do-seon
Department Of Dental Hygiene College Of Health Science Eulji University
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Do Kyung
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Ko Yeong
Oral Biology Research Institute And The Second Stage Of Bk21 Chosun University College Of Dentistry
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Jeong Soon-jeong
Oral Biology Research Institute And The Second Stage Of Bk21 Chosun University College Of Dentistry
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Park Kyung
Oral Biology Research Institute And The Second Stage Of Bk21 Chosun University College Of Dentistry
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Kanai Yoshikatsu
Division Of Bio-system Pharmacology Department Of Pharmacology Osaka University Graduate School Of M
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Park Joo-Cheol
Department of Oral Histology and Developmental Biology, Seoul NationalUniversity, School of Dentistry
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