Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
スポンサーリンク
概要
- 論文の詳細を見る
We analyzed the functional properties of five single nucleotide polymorphisms (SNPs) in organic cation transporter OCT3 gene (SLC22A3) resulting in the amino acid changes with a transient expression system. Three SNPs (A116S, T400I, and A439V) exhibited reduced uptake of both [3H]histamine and [3H]MPP+, although their protein expressions were detected in the plasma membrane of transfected cells. This study suggests that the OCT3 variants will contribute to inter-individual variations leading to the differences in cationic drug disposition as well as certain disease processes such as hypertension, allergic diseases, and neuropsychiatric diseases by the clearance of endogenous organic cations such as biogenic amines.
著者
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Endou Hitoshi
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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Anzai Naohiko
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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SAKURAI Hiroyuki
Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Med
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安西 尚彦
東京女子医科大学附属膠原病リウマチ･痛風センター
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安西 尚彦
杏林大学医学部薬理学教室
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Sakata Takeshi
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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Kimura Toru
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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Miura Daisaku
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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Fukutomi Toshiyuki
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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Takeda Michio
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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Takeda Michio
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Miura Daisaku
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Fukutomi Toshiyuki
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Endou Hitoshi
Department Of Pharmacology & Toxicology Kyorin University School Of Medicine
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Sakurai Hiroyuki
Department Of Hepatobiliary Pancreatic And Transplant Surgery Graduate School Of Medicine Mie Univer
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Anzai Naohiko
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Sakata Takeshi
Kobuchisawa Research Laboratories Fuji Biomedix Co. Ltd.
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Kimura Toru
Department Of Neurology Rakuwakai Otowa Hospital
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