Nicergoline Enhances Glutamate Uptake via Glutamate Transporters in Rat Cortical Synaptosomes(Highlighted paper selected by Editor-in chief)(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
To elucidate the mechanisms of neuroprotective action of nicergoline, we examined its effect on glutamate transport in rat cortical synaptosomes and cloned glutamate transporters. In synaptosomes, nicergoline enhanced the glutamate uptake at 1-10μM in standard medium and suppressed the increase of extracellular glutamate by reversed transport in low Na^+ medium. Apparent increase of extracellular glutamate concentration by dihydrokinate, an inhibitor of glial glutamate transporter GLT-1, was antagonized by nicergoline. In Xenopus oocytes expressing mouse neuronal glutamate transporter (mEAACl), the glutamate-induced inward current was enhanced by nicergoline. These results suggest that nicergoline reduces the extracellular glutamate concentration through its effect on glutamate transporters.
- 社団法人日本薬学会の論文
- 2004-06-01
著者
-
Endou Hitoshi
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
-
Kobayashi T
Faculty Of Science Shinshu University
-
Endou Hitoshi
杏林大学 医学部薬理学教室
-
Kawanishi T
大妻女子大学 食物学科
-
Endou H
Kyorin Univ. School Of Medicine Tokyo Jpn
-
NISHIDA Atsushi
Discovery and Pharmacology Research Laboratories, Tanabe Seiyaku Co., Ltd.
-
IWATA Hiroshi
Product Management Department, Pharmaceuticals Marketing Headquarters, Tanabe Seiyaku Co., Ltd.
-
KUDO Yukitsuka
Brain Function Research Institute, Inc., c
-
KOBAYASHI Tsutomu
o National Cardiovascular Cente
-
MATSUOKA Yuzo
Discovery and Pharmacology Research Laboratories, Tanabe Seiyaku Co., Ltd.
-
KANAI Yoshikatsu
Discovery and Pharmacology Research Laboratories, Tanabe Seiyaku Co., Ltd.
-
KOBAYASI TADASHI
Kobe Pharmaceutical University
-
Kawanishi Toru
国立医薬品食品衛生研究所
-
Kanai Yoshikatsu
Discovery And Pharmacology Research Laboratories Tanabe Seiyaku Co. Ltd.
-
Endou Hitoshi
Department Of Pharmacology & Toxicology Kyorin University School Of Medicine
-
Matsuoka Yuzo
Discovery And Pharmacology Research Laboratories Tanabe Seiyaku Co. Ltd.
-
Kudo Yukitsuka
Brain Function Research Institute Inc. C
-
Nishida A
Discovery And Pharmacology Research Laboratories Tanabe Seiyaku Co. Ltd.
-
古林 隆司
宇部興産株式会社研究開発本部宇部研究所医薬研究部
-
Iwata Hiroshi
Product Management Department Pharmaceuticals Marketing Headquarters Tanabe Seiyaku Co. Ltd.
関連論文
- Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
- Inhibition of L-Type Amino Acid Transporter Modulates the Expression of Cell Cycle Regulatory Factors in KB Oral Cancer Cells
- Children's toxicology from bench to bed - Drug-induced Renal Injury (3) : Drug transporters and toxic nephropathy in childhood
- Lipid Lowering Effects of High Linoleate and High α-Linolenate Diets in Rats and Mice. Consequence of Long-Term Feedings
- Synthetic Studies of Vitamin D Analogs. XXII.Synthesis and Antiproliferation Activity of Putative Metabolites of 1α, 25-Dihydroxy-22-oxavitamin D_3
- EFFECTS OF Mg AND K DEFICIENCY ON MALE AND FEMALE MICE
- Establishment and Characterization of Mammalian Cell Lines Stably Expressing Human L-Type Amino Acid Transporters
- Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms
- L-Type Amino Acid Transporter-1 Expressed in Human Astrocytomas, U343MGa(Biochemistry)
- Transport of methylmercury through the epithelial type amino acid transport system B^0(Proceedings of the 32nd Annual Meeting)
- P7-56 Identification of novel system L transporters and their methyl mercury-cysteine conjugates transport properties(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P7-20 Modulatory effects of membrane proteins interacting with essential large neutral amino acids transporter LAT1, on amino acid uptake in bladder transitional cell carcinoma line, T24(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTO
- Time Course of Expression of 7,12-Dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and Protein in Rat Liver
- P-21 Trasport of methyl mercury-cysteine conjugate by multispecific organic anion transport 3(Proceedings of the 27th Annual Meeting)
- Establishment of a Mouse Macula Densa Cell Line with an nNOS Promoter Driving EGFP Expression
- Rapid Control of Transmembrane Calcium Influx by 1α, 25-Dihydroxyvitamin D_3 and Its Analogues in Rat Osteoblast-Like Cells
- Synthetic Studies of Vitamin D Analogs. XXIV. Synthesis of Active Vitamin D_3 Analogs Substituted at the 2β-Position and Their Preventive Effects on Bone Mineral Loss in Ovariectomized Rats
- Mouse Organic Anion Transporter 2 (mOat2) Mediates the Transport of Short Chain Fatty Acid Propionate
- Nicergoline Enhances Glutamate Uptake via Glutamate Transporters in Rat Cortical Synaptosomes(Highlighted paper selected by Editor-in chief)(Pharmacology)
- Measurement of Glutamate Uptake and Reversed Transport by Rat Synaptosome Transporters(Pharmacology)
- Correlation of angiogenesis with ^F-FMT and ^F-FDG uptake in non-small cell lung cancer
- Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung
- L-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms
- Nephrin and Podocin Expression Around the Onset of Puromycin Aminonucleoside Nephrosis
- RELATIONSHIP BETWEEN γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY IN URINE AND RENAL PROXIMAL TUBULAR DAMAGE(S) BY NEPHROTOXIC AGENTS (The 6th Meeting for the Study of Toxic Effect)
- SUPPRESSIVE EFFECT OF DIPYRIDAMOLE ON THE PROTEINURIA OF AMINONUCLEOSIDE NEPHROSIS IN RAT.
- EFFECTS OF MERCURY ON THE STRUCTURAL GLYCOPROTEINS OF VARIOUS SEGMENTS IN ISOLATED NEPHRON (The 5th Meeting for the Study of Toxic Effect)
- EFFECTS OF MERCURY ON THE STRUCTURAL PROTEINS OF VARIOUS SEGMENTS IN ISOLATED NEPHRON (The Fourth Meeting for the Study of Toxic Effect)
- 215. TOXIC ACTION OF HEAVY METALS. 2. ANALYSIS OF PROTEINURIA DUE TO MERCURY (The Third Meeting for the Study of Toxic Effect)
- 103. EFFECT OF MERCURY ON THE NEWT KIDNEY (The Second Meeting for the Study of Toxic Effect)
- PROGRESS IN NEPHROTOXICOLOGY : FROM IN VIVO SCREENING TEST TO MOLECULAR MECHANISMS
- Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins
- Expression of Human Organic Anion Transporters in the Choroid Plexus and Their Interactions With Neurotransmitter Metabolites
- Role of Organic Anion Transporters in the Tubular Transport of Indoxyl Sulfate and the Induction of its Nephrotoxicity.(GENERAL SESSION BY POSTER PRESENTATION)(KIDNEYS AND URINARY EXCRETION SYSTEM)
- Induction of rat hepatic CYP 1A1, 1B1, and AhR by 7, 12-dimethylbenz[α]anthracene on prenatal 3, 3', 4, 4', 5-pentachlorobiphenyl exposure(Drug metabolism, Proceedings of the 32nd Annual Meeting)
- Evaluation of testicular toxicology in aging rats with prenatal exposure for 3, 3', 4, 4', 5-pentachlorobiphenyl(Proceedings of the 32nd Annual Meeting)
- Evaluation of testicular toxicology in puberty to adult rats with prenatal exposure for 3, 3', 4, 4', 5-pentachlorobiphenyl(Proceedings of the 32nd Annual Meeting)
- N-methyl-N-nitrosourea induced rat prostate carcinogenesis is modulated by prenatal 3, 3', 4, 4', 5-pentachlorobiphenyl exposure(Proceedings of the 32nd Annual Meeting)
- Preparation of New Nitrogen-Bridged Heterocycles. 56. Syntheses and Reactions of 1-[2,2-Bis(alkylthio)-1-(ethoxycarbonylacetyl)vinyl]pyridinium Salts
- Preparation of New Nitrogen-Bridged Heterocycles.51.^ Syntheses and Structures of Compounds Having Two Indolizine Nuclei in a Molecule
- Preparation of New Nitrogen-Bridged Heterocycles. 46. Selective Formation of 4(1H)-8,8a-Dihydro-1,4-thiazino[3,4,5-cd]indolizinone and (E)-3-(1,3-Oxathiol-2-ylidene)-2(3H)-indolizinone Derivatives
- Differential Expression of System L Amino Acid Transporters during Wound Healing Process in the Skin of Young and Old Rats(Molecular and Cell Biology)
- Chronic Effect of Cadmium on Bone and Vitamin D Metabolism in Ovariectomized Aged Rats (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Novel 2-Amino-1,4-dihydropyridine Calcium Antagonists. II. Synthesis and Antihypertensive Effects of 2-Amino-1,4-dihydropyridine Derivatives Having N, N-Dialkylaminoalkoxycarbonyl Groups at 3- and/or 5-Position
- Novel 2-Amino-1,4-dihydropyridine Calcium Antagonists. I. Synthesis and Antihypertensive Effects of 2-Amino-1,4-dihydropyridine Derivatives Having Nitroxyalkoxycarbonyl Groups at 3- and/or 5-Position
- O-58 Transport of a methylmercury-cysteine conjugate mediated by system L neutral amino acid transporters(Proceedings of the 27th Annual Meeting)
- Preparation of New Nitrogen-Bridged Heterocycles. 54. Increased Arene-Arene Interactions of 3-(Bicyclic and Tricyclic Arylmethylthio)thieno[3,4-b]indolizine Derivatives
- Preparation of New Nitrogen-Bridged Heterocycles. 53. Syntheses of 3-(Benzylthio)thieno[3,4-b]indolizine Derivatives and Their Intramolecular Arene-Arene Interactions
- Human Organic Anion Transporters Mediate the Transport of Tetracycline
- C-17 IDENTIFICATION OF A NOVEL LIVER SPECIFIC ORGANIC ANION TRANSPORTER SELECTIVE FOR CONJUGATED DRUGS AND STEROID HORMONES
- Simplified method for the determination of 25-hydroxy and 1α,25-dihydroxy metabolites of vitamins D_2 and D_3 in human plasma Application to nutritional studies
- A SENSITIVE METHOD FOR THE DETERMINATION OF 1,25-DIHYDROXYVITAMIN D IN PLASMA BY USING CALF THYMUS RECEPTOR
- Determination of Vitamin D2,D3 and their Metabolites in Plasma
- DETERMINATION OF VITAMIN D AND ITS METABOLITES IN BREAST AND COW'S MILK
- 25-HYDROXYVITAMIN D_3 BINDING PROTEIN IN RAT LYMPH
- Testicular Toxicology of Pubescent and Adult Rats Prenatally Exposure to 3,3',4,4',5-Pentachlorobiphenyl
- Expression of a system L amino acid transporter at testis of rats after prenatal exposure to di(n-butyl)phate(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- The role of amino acid transporters in the cytotoxicity of methylmercury.(GENERAL SESSION BY POSTER PRESENTATION)(ENVIRONMENTAL CHEMICALS,HEAVY METALS & CYTOTOXICITY)
- O10-17 Expression of system L amino acid transporters in the blood-tissue barriers and the transport of 35^S-methylmercury.
- Role of Mouse Organic Anion Transporter 3 (mOat3) as a Basolateral Prostaglandin E_2 Transport Pathway
- Human Organic Anion Transporter 4 Is a Renal Apical Organic Anion/Dicarboxylate Exchanger in the Proximal Tubules
- BCH, an Inhibitor of System L Amino Acid Transporters, Induces Apoptosis in Cancer Cells(Molecular and Cell Biology)
- FUNCTIONAL PROPERTIES OF MULTISPECIFIC AMINO ACID TRANSPORTERS AND THEIR IMPLICATIONS TO TRANSPORTER-MEDIATED TOXICTY
- Organic Anion Transporter Family : Current Knowledge
- System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells
- Purinoceptor-Mediated Calcium Mobilization and Cellular Proliferation in Cultured Bovine Corneal Endothelial Cells
- Molecular biology of multispecific organic anion transporter family (OAT family)
- 22D-09-3 Silica increases cytosolic calcium and causes cell injury in renal cell lines.
- STUDIES ON NITROSAMINE FORMATION BY THE INTERACTION BETWEEN DRUGS AND NITRITE. I. : Measurement of the amount of nitrosamine formed in rat and guinea pig stomachs.
- Effects of hexavalent chromium on lipid peroxidation and hydroxyl radical generation in mouse kidney.
- Effect of Cadmium on Bone and Vitamin D Metabolism in Rats (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Identification and Quantification of 1,25-Dihydroxyvitamin D_3 in Skin and Its Physiological Functions
- Functional Characterization and Immunohistochemical Localization of Organic Anion Transporter 1 (S1c22a6) from Mouse Kidney
- NARCOTIC PHYSICAL DEPENDENCE AND URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS
- Current Status and Future Perspective on Molecular Toxicology (KEYNOTE LECTURE) (Proceedings of the 30th Annual Meeting)
- B-12 EFFECT OF MERCURY CHLORIDE ON ANGIOTENSIN II-INDUCED [Ca^]_i INCREASE IN RAT EARLY PROXIMAL TUBULE
- Cis-platinum(II)-diamino dichloride(CDDP) induced toxicity in immortalized cell lines established from each nephron segment of transgenic mice harboring ts-SV40 T-antigen gene.
- Roles of glutamate transporters in neuronal cell death
- W2-1 SIGNIFICANCE OF ALTERNATIVE TOXICITY TESTING
- Human Nramp2 as a cadmium transporter.(GENERAL SESSION BY POSTER PRESENTATION)(ENVIRONMENTAL CHEMICALS,HEAVY METALS & CYTOTOXICITY)
- EVALUATION OF NEPHROTOXICITY
- DISTRIBUTION AND SOME CHARACTERISTICS OF CYTOCHROME P-450 IN THE KIDNEY
- "C-14 The intracellular mechanism for cisplatin-induced apoptosis in renal cell line
- LOSS OF VIABILITY AFTER DISULFIRAM TREATMENT WITHOUT PRECEDING DEPLETION OF INTRACELLULAR GSH
- ORIGIN AND CHARACTERISTICS OF FRESHLY ISOLATED RENAL CELLS OBTAINED BY PERFUSION OF COLLAGENASE IN VITRO
- COMPARISONS OF THE TOXICOKINETIC PARAMETERS IN RATS DETERMINED FOR LOW AND HIGH DOSE OF γ-CHLORDANE
- L-Type amino acid transporter 1 inhibitors inhibit tumor cell growth
- Interactions of Human-and Rat-Organic Anion Transporters With Pravastatin and Cimetidine
- Transport of ochratoxin A by renal multispecific organic anion transporter 1 and its effect on cell proliferation
- L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer
- Interactions of Human Organic Anion Transporters With Aristolochic Acids
- DISTRIBUTION OF GAMMA-GLUTAMYL TRANSPEPTIDASE AND GLUTAMINASE ISOENZYMES IN THE RABBIT SINGLE NEPHRON
- MICROPUNCTURE STUDY OF PROTEIN CONCENTRATION IN GLOMERULAR FLUID IN THE NEWT
- CYTOCHROME P-450 MONOOXYGENASE SYSTEM IN THE RABBIT KIDNEY: ITS INTRANEPHRON LOCALIZATION AND ITS INDUCTION
- Interactions of Human Organic Anion Transporters With Aristolochic Acids
- Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease
- Human urate transporter 1 (hURAT1) mediates the transport of orotate
- Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms
- Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
- A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A