Preparation of New Nitrogen-Bridged Heterocycles. 56. Syntheses and Reactions of 1-[2,2-Bis(alkylthio)-1-(ethoxycarbonylacetyl)vinyl]pyridinium Salts
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概要
- 論文の詳細を見る
The title compounds, readily available from the S-alkylation of pyridinium 1-[alkylthio(thiocarbonyl)]-(ethoxycarbonylacetyl)methylides with alkyl halides or alkyl bromoacetates, were treated with a base and then a dehydrogenating agent to provide some unique products such as 3-[bis(alkylthio)methylene]-2(3H)-indolizinones and dialkyl 7-methyl-4-oxo-1, 4, 8, 8a-tetrahydro-1, 4-thiazino[3, 4, 5-cd]indolizine-1, 5-dicarboxylates. On the other hand, similar reaction of these pyridinium salts in the absence of the dehydrogenating agent afforded alkyl 2-hydroxyindlizine-3-carboxythiolates, whose yields were increased by adding trifluoroacetic acid to the reaction mixture. The structures of some products were confirmed by the X-ray analyses.
- 公益社団法人日本薬学会の論文
- 2004-11-01
著者
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Suga Hiroyuki
岡山大学 医歯総研究 麻酔蘇生学
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Suga Hiroyuki
Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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Suga H
Department Of Physiology Ii Okayama University Medical School
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Kakehi A
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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OHTA Akira
Faculty of Science, Shinshu University
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Akikazu Kakehi
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Kobayashi T
Faculty Of Science Shinshu University
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Kakehi Akikazu
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Suga H
Department Of Systems Physiology Okayama University Graduate School Of Medicine Dentistry And Pharma
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Suga Hiroyuki
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Kakehi A
Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855
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Kawanishi T
大妻女子大学 食物学科
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Ohta A
Mitsubishi Electric Corp. Itami‐shi Jpn
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YAMAUCHI Yuuya
Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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YASURAOKA Katsuaki
Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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KOBAYASHI Tomoshige
Faculty of Science, Shinshu University
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Suga H
Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855
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KOBAYASI TADASHI
Kobe Pharmaceutical University
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Kawanishi Toru
国立医薬品食品衛生研究所
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Ohta A
Faculty Of Science Shinshu University
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Yamauchi Yuuya
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Yasuraoka K
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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古林 隆司
宇部興産株式会社研究開発本部宇部研究所医薬研究部
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SUGA Hiroyuki
Department of Cardiac Physiology, National Cardiovascular Center Research Institute
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