Left Ventricular Contractility and Energetic Cost in Disease Models : An approach from the pressure-volume diagram : CLINICAL EVALUATION OF CARDIAC PERFORMANCE
スポンサーリンク
概要
- 論文の詳細を見る
Left ventricular contractility and the energetic cost of contraction were assessed in various disease models in experimental animals utilizing frameworks of E_<max> (left ventricular contractility index) and pressure-volume area (PVA, a measure of total left ventricular mechanical energy expenditure) derived from the pressure-volume (P-V) diagram. Under various contractile conditions, PVA linearly correlates with myocardial oxygen consumption per beat (VO_2) in a load-independent manner. The reciprocal of the slope of the linear VO_2-PVA relation indicates "contractile efficiency" (the energy transduction efficiency from oxygen to total mechanical energy). It was similar between dog and rabbit hearts (about 40%) and was not significantly affected by enhanced contractility with calcium, epinephrine, or cardiac cooling, or by depressed contractility with propranolol, decreased coronary perfusion pressure, or stunned myocardium. However, in thyrotoxic rabbit hearts contractile efficiency was significantly depressed compared to normal hearts. On the other hand, the VO_2 intercept of the VO_2-PVA relation (PVA-independent VO_2), which reflects VO_2 for non-mechanical activities such as excitation-contraction coupling and basal metabolism, positively correlates with E_<max>' Therefore, the ratio of an increase in PVA-independent VO_2 to an increase in E_<max> indicates "oxygen cost of contractility". Oxygen cost of contractility was higher in stunned myocardium than in normal hearts, suggesting that the energy cost of calcium handling is elevated in stunned myocardium. Thus, using the frameworks of E_<max> and PVA, we can interconnect cardiac mechanics and energetics. Further, using the concepts of contractile efficiency and oxygen cost of contractility, we can approach the pathogenesis of variously altered contractile conditions.
- 社団法人日本循環器学会の論文
- 1992-07-20
著者
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Goto Yoichi
Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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Suga H
Department Of Physiology Ii Okayama University Medical School
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Suga Hiroyuki
Department Of Systems Physiology Okayama University Graduate School Of Medicine Dentistry And Pharma
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Hata Katsuya
Department Of Physiology Kawasaki Medical School
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Hisamatsu Kenichi
国立病院機構岡山医療センター 循環器科
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Hata Katsuya
Department Of Physiology Kawasaki Medical University
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Suga H
Department Of Systems Physiology Okayama University Graduate School Of Medicine Dentistry And Pharma
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Futaki Shiho
National Cardiovascular Center Research Institute
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TAKASAGO Toshiyuki
National Cardiovascular Center
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SAEKI Akio
National Cardiovascular Center
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NISHIOKA Takehiko
National Cardiovascular Center
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TAYLOR Tad
National Cardiovascular Center
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Goto Yoichi
The Departments Of Cardiovascular Dynamics And Internal Medicine National Cardiovascular Center
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FUTAKI Shiho
The Department of Pediatrics, National Cardiovascular Center
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GOTO0 YOICHI
The Department of Cardiovascular Dynamics, National Cadiovascular Center
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KAWAGUCHI OSAMU
The Department of Cardiovascular Dynamics, National Cadiovascular Center
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HATA KATSUYA
The Department of Cardiovascular Dynamics, National Cadiovascular Center
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TAKASAGO TOSHIYUKI
The Department of Cardiovascular Dynamics, National Cadiovascular Center
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SAEKI AKIO
The Department of Cardiovascular Dynamics, National Cadiovascular Center
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NISHIOKA TAKEHIKO
The Department of Cardiovascular Dynamics, National Cadiovascular Center
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SUGA HIROYUKI
The Department of Cardiovascular Dynamics, National Cadiovascular Center
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Hisamatsu Kenichi
Department Of Cardiology National Hospital Organization Okayama Medical Center
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Kawaguchi Osamu
Department Of Cardiovascular Dynamics National Cardiovascular Center
-
Fukui Sugao
The Department Of Cardiovascular Dynamics National Cadiovascular Center
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Futaki Shiho
The Department Of Cardiovascular Dynamics National Cadiovascular Center
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Goto0 Yoichi
National Cardiovascular Center
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Hashimoto Katsushi
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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