Quantitative Evaluation of Left Ventricular Regional Work from Wall Tension-Regional Area Loop in Canine Heart : SYMPOSIUM ON MECHANICS OF CONTRACTION AND RELAXATION OF THE ISCHEMIC MYOCARDIUM : 50th Annual Scientific Session of Japanese Circulation Socie
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概要
- 論文の詳細を見る
We evaluated left ventricular (LV) regional work from a wall tension-regional area (T=A) loop using sonomicrometers in the excised cross-circulated canine left ventricle connected to a volume servo pump. Regional work assessed from a T-A loop closely agreed with the predicted value calculated from LV stroke work and percent regional area under conditions of the control state, dobutanime infusion, and global ischemia. In addition, globally integrated regional work over the entire ischemic and non-ischemic zones agreed closely with LV stroke work either before or after coronary occlusion. These results indicate that LV regional work can be assessed reliably from the T-A loop in both normal and regionally ischemic hearts. Regional work correlated linearly with end-diastolic regional area, indicating a regional Frank-Starling relation, and the slope of this relationship increased with dobutanime infusion and decreased with global ischemia. The correlation between regional work and LV stroke work was also linear and the regression line was the same during the control state and global ischemia, indicating a constant relationship between the work of a specific wall region and LV stroke work regardless of global changes in contractile state. However, after regional ischemia, this regression line apparently shifted downward because T-A loops in the ischemic region were extremely deformed and regional work markedly decreased. From these results, we concluded that T-A loops are a reliable and useful means of assessing regional contractile performance of the LV.
- 社団法人日本循環器学会の論文
- 1987-01-20
著者
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Goto Yoichi
Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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Suga H
Department Of Physiology Ii Okayama University Medical School
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Suga Hiroyuki
Department Of Systems Physiology Okayama University Graduate School Of Medicine Dentistry And Pharma
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Suga H
Department Of Systems Physiology Okayama University Graduate School Of Medicine Dentistry And Pharma
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Goto Yoichi
The Division of Cardiology, National Cardiovascular Center
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Goto Yoichi
The Departments Of Cardiovascular Dynamics And Internal Medicine National Cardiovascular Center
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SUGA HIROYUKI
The Department of Cardiovascular Dynamics, National Cadiovascular Center
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Suga Hiroyuki
The Departments Of Cardiovascular Dynamics And Internal Medicine National Cardiovascular Center
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HIRAMORI MATSUHIKO
The Departments of Cardiovascular Dynamics and Internal Medicine,National Cardiovascular Center
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Goto0 Yoichi
National Cardiovascular Center
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Hiramori Matsuhiko
The Departments Of Cardiovascular Dynamics And Internal Medicine National Cardiovascular Center
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