Role of Cytokines and Adhesion Molecules in Ischemia and Reperfusion in Patients With Acute Myocardial Infarction
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概要
- 論文の詳細を見る
Although acute myocardial infarction (AMI) may involve both plaque rupture and ischemia-reperfusion injury, the pathogenesis of these phenomena is unclear. To elucidate the pathogenesis of AMI, serial measurements of platelet activating factor (PAF), interleukin-6 and cell adhesion molecules were made in patients with AMI. The PAF levels were measured upon hospital admission and at 24 and 72h in 8 patients with AMI. Serum levels of interleukin-6, soluble E-selectin (sE-selectin), soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured upon admission and at 24h and 4 weeks in 30 patients with AMI and 15 patients with stable effort angina. PAF levels were higher in patients with AMI than in normal volunteers; the increased levels lasting at least 72h. In contrast, interleukin-6 increased at 24h. sE-selectin was elevated at admission and sVCAM-1 increased later. sE-selectin levels upon admission in patients with additional ST-segment elevation after reperfusion were significantly higher than those in patients without ST-elevation. In patients with AMI, the time-course of changes in blood levels of cytokines varied according to the individual substances. Although it is unclear what is the precise role of each of the cytokines in the pathophysiology of AMI, sE-selectin may be possibly related to the reperfusion injury in the infarcted myocardium.
- 社団法人日本循環器学会の論文
- 1999-04-20
著者
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Nonogi Hiroshi
Department Of Cardiovascular Medicine National Cardiovascular Center
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Morii Isao
Division Of Cardiology Department Of Internal Medicine Hokusetsu General Hospital
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Goto Yoichi
Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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Daikoku Satoshi
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Miyao Yuji
Department of Cardiovascular Medicine, National Hospital Organization Kumamoto Medical Center
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Itoh Akira
Department Of Cardiology Osaka City General Hospital
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MIYAZAKI Shunichi
Department of Physiology, Tokyo Women's Medical University School of Medicine
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Morii Isao
Department of Cardiology, National Cardiovascular Center
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Nonogi Hiroshi
Department Of Cardiology National Cardiovascular Center
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Miyao Yuji
The Division Of Cardiology National Cardiovascular Center
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MATSUMOTO Takahiro
the Division of Cardiology National Cardiovascular Center
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Matsumoto Takahiro
Department of Cardiovascular Medicine, National Kyushu Medical Center
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Itoh Akira
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Daikoku Satoshi
Department of Internal Medicine, Division of Cardiology, National Cardiovascular Center
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Ito Akira
Division Of Cardiology Osaka City General Hospital
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Goto Yoichi
Department Of Cardiology National Cardiovascular Center
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Morii Isao
Department Cardiology National Cardiovascular Center
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Miyazaki Shunichi
Department Cardiology National Cardiovascular Center
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Matsumoto Takahiro
Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome
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Miyao Yuji
Department Of Cardiology Cardiovascular Center National Hospital Organization Kumamoto Medical Cente
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Nonogi Hiroshi
Department Of Cardiology Medical School Osaka University
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Matsumoto Takahiro
Department Of Cardiology National Kyushu Medical Center
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Itoh Akira
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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