Assessment of Plasma miRNAs in Congestive Heart Failure

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概要

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• Background: MicroRNAs (miRNAs) are endogenous small RNAs that are 21-25 nucleotides in length. Recently, plasma miRNAs have been reported to be sensitive and specific biomarkers of various tissue injuries and pathological conditions. The goal of this study was to assess plasma miRNA profiles and to identify plasma miRNAs that are differentially expressed in patients with heart failure. Methods and Results: A total of 33 patients with ischemic heart diseases and 17 asymptomatic controls were recruited. In 10 patients with heart failure, miRNAs were assessed at both NYHA IV and III. miRNA array analyses were found to be not appropriate for plasma miRNA profiling. The plasma concentrations of well-characterized miRNAs (miR-126, 122 and 499) were assessed by a real-time reverse transcription-polymerase chain reaction using an artificial small RNA as an internal standard. Plasma concentrations of miR-126 were negatively correlated with age and logBNP. In 10 patients with heart failure, plasma concentrations of miR-126 were up-regulated with improvement of the NYHA class from IV to III. Conclusions: The plasma concentration of miR-126 was negatively correlated with age and NYHA class, and could be a useful biomarker for heart failure. (Circ J 2011; 75: 336-340)

• 2011-01-25

著者

• IWAI Naoharu

  Department of Epidemiology, Research Institute, National Cardiovascular Center

• Naritomi Hiroaki

  Division Of Cardiology National Cardiovascular Center

• Nakagami Hironori

  Division Of Gene Therapy Science Osaka University Graduate School Of Medicine

• Nonogi H

  Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center

• Nonogi Hiroshi

  Department Of Cardiovascular Medicine National Cardiovascular Center

• Goto Y

  Division Of Cardiology National Cardiovascular Center

• Goto Yoichi

  Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute

• Nonogi Hiroshi

  Cardiology And Emergency Medicine National Cardiovascular Center

• Nakanishi Michio

  Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine

• Nonogi Hiroshi

  Department Of Cardiology National Cardiovascular Center

• Iwai Naoharu

  Department Of Epidemiology Research Institute National Cardiovascular Center

• Iwai Naoharu

  Department Of Epidemiology National Cardiovascular Center

• Nakahama Hajime

  国立循環器病センター 高血圧腎臓内科

• Nakahama Hajime

  Division Of Hypertension And Nephrology National Cardiovascular Center

• FUKUSHIMA Yasue

  Department of Epidemiology, Research Institute, National Cardiovascular Center

• Nakagami Hironori

  Division Of Clinical Gene Therapy Osaka University Graduate School Of Medicine

• Nakanishi Michio

  Department Of Cardiology Kokura Memorial Hospital

• Nonogi Hiroshi

  Saitama Medical University

• Inamoto Nozomu

  Division Of Preventive Cardiology National Cardiovascular Center

• Nakanishi Michio

  Department Of Cardiology National Cardiovascular Center

• Iwai N

  Department Of Epidemiology Research Institute National Cardiovascular Center

• Iwai Naoharu

  National Cardiovascular Center Research Institute

• Iwai Naoharu

  Research Institute National Cardiovascular Center

• Goto Yoichi

  Department Of Cardiology National Cardiovascular Center

• Iwai Naoharu

  Department Of Epidemiology Research Institute National Cardio-vascular Center

• Fukushima Yasue

  Department Of Genomic Medicine National Cerebral And Cardiovascular Center

• Nonogi Hiroshi

  Department Of Cardiology Medical School Osaka University

• Nonogi Hiroshi

  Division Of Cardiovascular Medicine National Cardiovascular Center

• Iwai Naoharu

  Department Of Genomic Medicine Research Institute National Cerebral And Cardiovascular Center

• Nakajima Hiroyuki

  Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Research Center

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