Validation of the Association Between the Gene Encoding Proteasome Subunit α Type 6 and Myocardial Infarction in a Japanese Population

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概要

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• Background Recently, a large case-control study (2,851 cases and 2,592 controls) reported that a functional single nuclear polymorphism (SNP) in the proteasome subunit a type 6 gene (PSMA6) conferred a risk of myocardial infarction (MI) in a Japanese population. The SNP (exon 1, -8C/G) is located in the 5' untranslated region of exon 1, and the risk-conferring allele G appears to enhance the transcription of PSMA6, which may exaggerate inflammation through activation of nuclear factor-/c /? protein. The frequency of the risk conferring genotype (GG) in cases was reported to be greater than that in controls (12.4% vs 8.9%). The purpose of the present study was to validate this observation in our study population. Methods and Results Subjects with MI (n=433) were recruited from the outpatient clinic of the National Cardiovascular Center. Control subjects (n=2,186) were recruited from the Suita study. The frequencies of the GG genotype did not significantly differ between the control (9.8%) and MI groups (10.6%). Moreover, this genotype was not associated with C reactive protein levels in the Suita study. However, the GG genotype was significantly associated with greater intima-media thickness (n=2,051, p=0.015) after adjusting for blood pressure, sex, body mass index and age in the Suita study. Conclusion The reported genotype in PSMA6 appears not to contribute appreciably to MI, but may contribute slightly to atherosclerosis in the present study population.

• 社団法人日本循環器学会の論文
• 2007-03-20

著者

• IWAI Naoharu

  Department of Epidemiology, Research Institute, National Cardiovascular Center

• KOKUBO Yoshihiro

  Department of Preventive Cardiology, National Cardiovascular Center

• Naritomi Hiroaki

  Division Of Cardiology National Cardiovascular Center

• Nonogi H

  Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center

• Nonogi Hiroshi

  Cardiology And Emergency Medicine National Cardiovascular Center

• OKAYAMA Akira

  Department of Preventive Cardiology, National Cardiovascular Center

• Takashima Naoyuki

  Department of Health Science, Shiga University of Medical Science

• Sugimoto Ken

  東北大学 臨床薬学

• Iwai Naoharu

  Department Of Epidemiology Research Institute National Cardiovascular Center

• Iwai Naoharu

  Department Of Epidemiology National Cardiovascular Center

• Nakamura Toshikazu

  Department Of Tumor Pathology Gunma University Graduate School Of Medicine

• Nakahama Hajime

  Division Of Hypertension And Nephrology National Cardiovascular Center

• Katanosaka Yuki

  国立循環器病センター

• Shimamoto Kazuaki

  帝京大学 医学部内科

• Goto Yoichi

  The Division of Cardiology, National Cardiovascular Center

• Shioji Keisuke

  Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University

• Shioji Keisuke

  Department Of Cardiology Kishiwada City Hospital

• Shioji Keisuke

  国立循環器病センター 疫学部

• Shioji Keisuke

  Department Of Epidemiology National Cardiovascular Center

• NONOGI Hiroshi

  the Division of Cardiology National Cardiovascular Center

• Nonogi Hiroshi

  Saitama Medical University

• Okayama A

  The First Institute Of Health Service Japan Anti-tuberculosis Association

• Okayama Akira

  Department Of Orthopedic Surgery Hyogo College Of Medicine

• Inamoto Nozomu

  Division Of Preventive Cardiology National Cardiovascular Center

• Kokubo Yoshihiro

  Department Of Cardiology National Cardiovascular Center

• Goto Yoichi

  The Departments Of Cardiovascular Dynamics And Internal Medicine National Cardiovascular Center

• Nakamura Tsuneya

  Department Of Endoscopy Aichi Cancer Center Hospital

• Iwai N

  Department Of Epidemiology Research Institute National Cardiovascular Center

• Iwai Naoharu

  National Cardiovascular Center Research Institute

• Iwai Naoharu

  Research Institute National Cardiovascular Center

• Takashima Naoyuki

  Department Of Health Science Shiga University Of Medical Science

• Takashima Naoyuki

  Department Of Epidemiology National Cardiovascular Center

• Okayama Akira

  Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine Nakanoshima

• Nakamura T

  Department Of Gastroenterology Aichi Cancer Center Hospital

• Nakamura Tuneya

  Department Of Endoscopy Aichi Cancer Center Hospital

• Iwai Naoharu

  Department Of Epidemiology Research Institute National Cardio-vascular Center

• Nakamura Toshiyuki

  Department Of Internal Medicine Gifu Red Cross Hospital

• Nonogi Hiroshi

  Division Of Cardiovascular Medicine National Cardiovascular Center

• Iwai Naoharu

  Department Of Genomic Medicine Research Institute National Cerebral And Cardiovascular Center

• TAKASHIMA Naoyuki

  Lifestyle-Related Disease Prevention Center, Shiga University of Medical Science

• Nakajima Hiroyuki

  Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Research Center

• Nakamura Toshiyuki

  Department Of Gastroenterology Gifu Red Cross Hospital

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