Assessment of Genetic Effects of Polymorphisms in the MCP-1 Gene on Serum MCP-1 Levels and Myocardial Infarction in Japanese

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概要

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• Background Recently, the Framingham Heart Study reported that genetic variations in CCL2 influence serum levels of monocyte chemoattractant protein-1 (MCP-1) and the incidence of myocardial infarction (MI). The purpose of the present study was to investigate the possible involvement of CCL2 in the pathogenesis of atherosclerosis and MI in Japanese. Methods and Results Multiple regression analysis indicated that the MCP-1 levels were significantly influenced by various factors including age, body mass index, smoking, alcohol intake, high density lipoprotein-cholesterol, and systolic blood pressure. Moreover, the serum MCP-1 level was significantly correlated with intimamedia thickness (p<0.0001). However, this association disappeared when other clinical confounding factors were included in the analyses. Comprehensive analysis of common polymorphisms of CCL2 in a large community-based population and in subjects with MI found that the A(-2138)T polymorphism affected the serum MCP-1 level in a subgroup of subjects 65 years and older. However, no significant differences in the frequencies of any of the polymorphisms or haplotypes were found between subjects with and without MI. None of the polymorphisms in CCL2 affected carotid atherosclerosis. Conclusions The serum MCP-1 level was a good surrogate marker of atherosclerosis in the present study population. Although genetic variations in CCL2 may have some influence on MCP-1 production, their influence does not seem to contribute appreciably to atherosclerosis in Japanese. The present results did not support the recently published findings from the Framingham Heart Study. The discrepancy between the 2 studies may be related to differences in confounding factors that contribute to MCP-1 levels and in the haplotype structure of the 2 populations.

• 社団法人日本循環器学会の論文
• 2006-06-20

著者

• IWAI Naoharu

  Department of Epidemiology, Research Institute, National Cardiovascular Center

• KOKUBO Yoshihiro

  Department of Preventive Cardiology, National Cardiovascular Center

• Naritomi Hiroaki

  Division Of Cardiology National Cardiovascular Center

• Nonogi H

  Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center

• Nonogi Hiroshi

  Department Of Cardiovascular Medicine National Cardiovascular Center

• Goto Yoichi

  Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute

• Hiro Takafumi

  Departments Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine

• Nonogi Hiroshi

  Cardiology And Emergency Medicine National Cardiovascular Center

• MIYAZAKI Shunichi

  Department of Physiology, Tokyo Women's Medical University School of Medicine

• Nonogi Hiroshi

  Department Of Cardiology National Cardiovascular Center

• Tomoike Hitonobu

  Department of Cardiology, National Cardiovascular Center

• OKAYAMA Akira

  Department of Preventive Cardiology, National Cardiovascular Center

• Iwai Naoharu

  Department Of Epidemiology Research Institute National Cardiovascular Center

• Iwai Naoharu

  Department Of Epidemiology National Cardiovascular Center

• Katanosaka Yuki

  国立循環器病センター

• Okayama Akira

  Department Of Orthopedic Surgery Hyogo College Of Medicine

• Inamoto Nozomu

  Division Of Preventive Cardiology National Cardiovascular Center

• Kokubo Yoshihiro

  Department Of Cardiology National Cardiovascular Center

• KAJIMOTO Kazuaki

  Department of Epidemiology, Research Institute, National Cardiovascular Center

• Tomoike Hitonobu

  Department Of Cardiology National Cardiovascular Center

• Iwai N

  Department Of Epidemiology Research Institute National Cardiovascular Center

• Iwai Naoharu

  National Cardiovascular Center Research Institute

• Iwai Naoharu

  Research Institute National Cardiovascular Center

• Goto Yoichi

  Department Of Cardiology National Cardiovascular Center

• Tomoike Hitonobu

  Able Corporation:department Of Biotechnology School Of Engineering Nagoya University

• Tomoike Hitonibu

  Department Of Cardiology National Cardiovascular Center

• Okayama Akira

  Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine Nakanoshima

• Miyazaki Shunichi

  Department Cardiology National Cardiovascular Center

• Takenaka Hiroaki

  First Department Of Surgery Yamaguchi University School Of Medicine

• Iwai Naoharu

  Department Of Epidemiology Research Institute National Cardio-vascular Center

• Kajimoto Kazuaki

  Department Of Epidemiology Divisions Of Preventive Medicine

• Nonogi Hiroshi

  Department Of Cardiology Medical School Osaka University

• Nonogi Hiroshi

  Division Of Cardiovascular Medicine National Cardiovascular Center

• TOMOIKE Hitonobu

  Sakakibara Heart Institute

• Hozumi Takeshi

  Division Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center

• Iwai Naoharu

  Department Of Genomic Medicine Research Institute National Cerebral And Cardiovascular Center

• Nakajima Hiroyuki

  Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Research Center

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