A Genome-Wide Association Study of Hypertension-Related Phenotypes in a Japanese Population
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概要
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Background: Large-scale genome-wide association studies (GWAS) have been successful in identifying genes that contribute to common diseases and phenotypes. A GWAS of hypertension-related phenotypes in a Japanese population was conducted in the current study. Methods and Results: A total of 936 participants were recruited from the Suita Study and a GWAS with 538,732 single nucleotide polymorphisms (SNP) was performed. The phenotypes included were systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI), waist-to-hip ratio (WHR), plasma renin activity (PRA), plasma aldosterone concentration (PAC), plasma brain natriuretic peptide (BNP) concentration and alcohol consumption (AC). The SNP exceeding the genome-wide significance level were subjected to subsequent association studies using samples available from the Suita Study and Nomura Study. There is no master gene in the Japanese population that profoundly affects SBP, DBP, BMI, WHR, PRA and PAC. AC was influenced by the functional polymorphism in ALDH2, which affected BP levels in men. The BNP concentration was influenced by a polymorphism in the 3 region of the gene encoding for BNP. However, this polymorphism did not influence blood pressure (BP). Six SNP were identified to be associated with hypertension in both the Suita and Nomura studies. Conclusions: Although several candidate SNP relevant to hypertension and those influencing AC and BNP were identified, our middle-sized GWAS indicated that there is no master gene in Japanese people that profoundly affects BP-related phenotypes. (Circ J 2010; 74: 2353-2359)
- 2010-10-25
著者
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HIURA Yumiko
Department of Epidemiology, Research Institute, National Cardiovascular Center
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TABARA Yasuharu
Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine
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KOKUBO Yoshihiro
Division of Preventive Cardiology, National Cardiovascular Center
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OKAMURA Tomonori
Division of Preventive Cardiology, National Cardiovascular Center
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TOMOIKE Hitonobu
Division of Preventive Cardiology, National Cardiovascular Center
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IWAI Naoharu
Department of Epidemiology, Research Institute, National Cardiovascular Center
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Tomino Y
Department Of Basic Medical Research And Education Ehime University Graduate School Of Medicine
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荻原 俊男
Division Of Preventive Cardiology National Cardiovascular Center
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MIKI Tetsuro
Department of Geriatric Medicine, Ehime University Graduate School of Medicine
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喜多 義邦
Division Of Preventive Cardiology National Cardiovascular Center
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Hiro Takafumi
Departments Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
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Kotani Yasushi
国立循環器病センター 予防検診
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Kosakai Yoshio
Department Of Cardiovascular Surgery National Cardiovascular Center
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Mochizuki T
Division Of Anti-aging And Genomics Ehime Proteo-medicine Research Center
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Miki Tetsuro
東北大学 臨床薬学
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Mochizuki T
Department Of Radiology Ehime University School Of Medicine Shitsukawa
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Miki Tetsuro
愛媛大学 病態情報内科学
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Miki Tetsuro
国立循環器病センター研究所 疫学部
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Tabara Yasuharu
国立循環器病センター研究所 疫学部
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Tabara Yasuharu
自治医科大学 循環器内科
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Tabara Yasuharu
西予市立野村病院 内科
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Ohama Tohru
大阪大学 医学系研究科循環器内科学
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Kawano Yuhei
国立循環器病センター 高血圧腎臓内科
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Tochikubo Osamu
横浜市立大学 第2内科
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Kaneko Yoshihiro
Second Department Of Internal Medicine Yokohama City University Hospital
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Tsubakihara Yoshiharu
大阪府立病院機構大阪府立急性期総合医療センター 腎臓・高血圧内科
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Tsubakihara Yoshiharu
Department Of Nephrology Osaka Prefectural Hospital
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Tomoike Hitonobu
Division Of Preventive Cardiology National Cardiovascular Center
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Tomoike Hitonobu
国立循環器病センター 疫学部
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Kokubo Yoshihiro
国立循環器病センター研究所 疫学部
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Kokubo Yoshihiro
愛媛大学 医学系研究科医療環境情報解析学講座公衆衛生健康医学
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Yokoi Hirokazu
Department Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Tsubakimoto Yoshinori
Department Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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Tsubakimoto Yoshinori
Department Of Cardiolgy Kyoto Prefectural University Of Medicine
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TSUKAMOTO Yusuke
Syuwa General Hospital
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Ohama Tohru
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Tochikubo Osamu
Division Of Cardiology Yokohama City University Medical Center
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Kaneda Yasufumi
Division Of Gene Therapy Science Osaka University
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Tabara Yasuharu
Department Of Basic Medical Research And Education Ehime University Graduate School Of Medicine
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Ohkubo Takayoshi
東北大学 臨床薬学
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Ohkubo Takayoshi
The Department Of Public Health Tohoku University Graduate School Of Pharmaceutical Science And Medi
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荻原 俊男
大阪大 大学院医学系研究科 生体制御医学専攻 加齢医学
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Okura Takafumi
愛媛大学 医学系研究科病態情報内科学
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Hoshikawa Yoshiko
鳥取大学 医学系研究科遺伝子医療学
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Hiura Yumiko
Department Of Epidemiology Research Institute National Cardiovascular Center
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Hiro Takafumi
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Yasue H
Division Of Molecular And Genetic Medicine Department Of Genetic Medicine And Regenerative Therapeut
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Hanawa Takao
Department Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
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Ohtsuka Tomoaki
愛媛大学 医学系研究科臨床看護学
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荻原 俊男
大阪大学 加齢医学
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Iwai Naoharu
Department Of Epidemiology Research Institute National Cardiovascular Center
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Iwai Naoharu
Department Of Epidemiology National Cardiovascular Center
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Kaneko Yoshihiro
Department Of Internal Medicine Jikei University School Of Medicine
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Tarutani Yasuhiro
Division Of Cardiology Department Of Medicine Kohka Public Hospital
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Kobayashi Yoshio
Cardiovascular Division National Cardiovascular Center
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Mochizuki Teruhito
Department Of Radiology Ehime University School Of Medicine Shitsukawa
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Katanosaka Yuki
国立循環器病センター
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Honda Toshihiro
Departments Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
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喜多 義邦
島根大学 医学部環境保健医学講座公衆衛生学
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Tochikubo Osamu
Division Of Preventive Cardiology National Cardiovascular Center
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Tochikubo Osamu
The Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Obara Taku
東北大学 臨床薬学
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Obara Taku
Department Of Clinical Pharmacology And Therapeutics Tohoku University Graduate School Of Pharmaceut
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Kosakai Yoshio
Department Of Cardiovascldar Surgery National Cardiovascudar Center
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Okuda Tomohiko
国立循環器病センター研究所 疫学部
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Okuda Tomohiko
Research Institute National Cardiovascular Center
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Tanabe Yasuhiko
Niigata Prefectural Shibata Hospital
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Tatara Yuji
大阪大学 老年・腎臓内科学
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Tatara Yuji
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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Kokubo Yoshihiro
Department Of Preventive Cardiology National Cardiovascular Center
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荻原 俊男
大阪大学 医学部 加齢医学 講座
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YAMABE Hideaki
Hirosaki University School of Medicine
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Miki Tetsuro
愛媛大学 医学部老年医学
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Okuda Tomohiro
Research Institute National Cardiovascular Center
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Inamoto Nozomu
Division Of Preventive Cardiology National Cardiovascular Center
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Hozumi Takeshi
Department Of Internal Medicine And Cardiology Graduate School Of Medicine Osaka City University
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Kokubo Yoshihiro
Cardiovascular Division National Cardiovascular Center
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Tomino Yasuhiko
Department Of Medicine Juntendo University School Of Medicine
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Tomoike Hitonobu
Cardiovascular Division Of Internal Medicine National Cardiovascular Center
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Tomita Y
Kyushu Inst. Technology Kitakyushu Jpn
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Ojima Toshiyuki
Hamamatsu Univ. School Of Medicine
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Okubo Takayoshi
Department Of Planning For Drug Development And Clinical Evaluation Tohoku University
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Kawagoe Yasuhiro
HIJC Investigators
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Harada Takehiko
Department Of Internal Medicine Tokushima University
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Kokubo Yoshihiro
Division Of Cardiovascular Preventive Medicine National Cardiovascular Center
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TAKADA YASUHARU
Saijo Central Hospital
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Kakeji Yosihiro
九州大学 医学研究院消化器・総合外科
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Tarutani Yasuhiro
Department Of Cardiology Kohka Public Hospital
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Okura Takafumi
The Second Department Of Internal Medicine Ehime University School Of Medicine
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Yoshita Katsushi
Project For The National Health And Nutrition Survey National Institute Of Health And Nutrition
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Iwai N
Department Of Epidemiology Research Institute National Cardiovascular Center
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Iwai Naoharu
National Cardiovascular Center Research Institute
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Iwai Naoharu
Research Institute National Cardiovascular Center
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Miki Tetsuro
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
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Ogihara Toshio
Department Of Medicine And Gerictrics Osaka University Medical School
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Tochikubo Osamu
The Second Department Of Internal Medicine Yokohama City University
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Okura Takafumi
Department Of Planning For Drug Development And Clinical Evaluation Tohoku University
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Tomoike Hitonobu
Able Corporation:department Of Biotechnology School Of Engineering Nagoya University
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Tomoike Hitonibu
Department Of Cardiology National Cardiovascular Center
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Kadoshima Yoko
Department Of Public Health Kanazawa Medical University
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Miyazaki T
Department Of Pathology Ehime University School Of Medicine
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Miyazaki Tatsuhiko
Department Of Radiology Ehime University School Of Medicine
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Taniyama Yoshihiro
Division Of Nephrology Sendai Social Insurance Hospital
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Kosakai Yoshio
National Cardiovascular Center
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Okamura Tomonori
Department Of Health Science Shiga University Of Medical Science
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Takenaka Hiroaki
First Department Of Surgery Yamaguchi University School Of Medicine
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Hiura Yumiko
Department Of Genomic Medicine Research Institute National Cerebral And Cardiovascular Center
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Takenaka Hiroaki
Department Of Surgery Yamaguchi University School Of Medicine
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Tokita Yasuo
Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Kaneda Yoshio
The 1st Dept. Of Pathology Tokyo Women's Medical College
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Horie Toshinobu
Departments Of Internal Medicine
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Takeya Yasushi
Department Of Geriatric Medicine
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Matayoshi Tetsutaro
Division Of Hypertension And Nephrology National Cardiovascular Center
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Iwai Naoharu
Department Of Epidemiology Research Institute National Cardio-vascular Center
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Iino Yasuhiko
Division Of Nephrology Department Of Internal Medicine Juntendo University School Of Medicine
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Ohtsuka Tomoaki
Department Of Integrated Medicine And Informatics Ehime University Graduate School Of Medicine
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Okamura Tomonori
Division Of Preventive Cardiology National Cardiovascular Center
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Yoshida Toshiharu
Department Of Nephrology Sendai Shakaihoken Hospital
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Ohtsuki Taisuke
Nervous And Muscular Disorders National Center For Neurology And Psychiatry
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Tomoike Hitonobu
Division Of Cardiovascular Medicine National Cardiovascular Center
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Ogihara T
Osaka Univ. Medical School Osaka Jpn
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Horie Toshinobu
The Heart Institute Of Japan Tokyo Women's Medical College
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Taguma Yoshio
Department Of Nephrology Sendai Shakaihoken Hospital
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Kokubo Yoshihiro
国立循環器病センター 予防検診部
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Yoshihiro Kanako
Second Department Of Internal Medicine Yokohama City University Hospital
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Honda Toshihiro
Saiseikai Kumamoto Hospital
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Ogihara Toshio
Department Of Medicine And Geriatrics Osaka University Medical School
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Tsukamoto Yusuke
Division Of Nephrology Department Of Internal Medicine Juntendo University School Of Medicine
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Taniyama Yoshiaki
Department Of Clinical Gene Therapy
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Onishi Toshio
Department Of Geriatric Medicine Osaka University Medical School
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Kakizawa Yoshiko
Department Of Cardiology Tokyo Women's Medical University
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TAGUMA Yoshio
Sendai Shakaihoken Hospital
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Hozumi Takeshi
The Department Of Internal Medicine And Cardiology Osaka City University School Of Medicine
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Takemura Yukihiro
Department Of Geriatric Medicine And Nephrology Osaka University Graduate School Of Medicine
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Horie Toshinobu
Tokyo Women's Medical College The Heart Institute Of Japan
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TOMOIKE Hitonobu
Sakakibara Heart Institute
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Ogihara Toshio
The Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu Universit
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Takigami Yoshiichi
The 2nd Department Of Internal Medicine Sapporo Medical College Sapporo
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Miki Tetsuro
Department Of Diagnostic And Therapeutic Radiology Ehime University Graduate School Of Medicine
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Tomoike Hitonobu
Division Of Cardiovascular Medicine
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Mochizuki Teruhito
Department Of Pathology Ehime University School Of Medicine
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Hozumi Takeshi
Division Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center
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Iwai Naoharu
Department Of Genomic Medicine Research Institute National Cerebral And Cardiovascular Center
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Hiura Yumiko
Department Of Epidemiology Research Institute National Cardio-vascular Center
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TOMOIKE Hitonobu
Division of Cardiology, Okayama University
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