Sustained Upregulation of Inflammatory Chemokine and Its Receptor in Aneurysmal and Occlusive Atherosclerotic Disease : Results From Tissue Analysis With cDNA Macroarray and Real-Time Reverse Transcriptional Polymerase Chain Reaction Methods

スポンサーリンク

概要

• 論文の詳細を見る

• Background Although cytokines are known to be pivotal in the development of atherosclerotic diseases, few data exist regarding their expressions in the established stages such as aneurysmal or occlusive lesions. Therefore, in the present study the gene expression levels of cytokine-related substances in abdominal aortic aneurysm (AAA) and carotid artery stenosis (CAS) were determined using cDNA macroarray and real-time reverse transcriptase polymerase chain reaction (RT-PCR) methods. Methods and Results Tissue samples were obtained from 31 patients with AAA and 24 with CAS. The arrayspecific [^<33>P]-labeled cDNA probe mixture synthesized from 2.5μg total RNA with gene-specific primers was hybridized with nylon membranes containing 375 cDNA clones. Densitometric analysis confirmed differences in expression (>5-fold) for 97 of the cytokine-related gene products between AAA and adjacent control tissue. Among these, simultaneous upregulation was found in the expression of interleukin (IL)-8 (9-fold) and its receptor, CXCR-2(11-fold). Thus, the expressions of IL-8 and CXCR-2 were further quantified by real-time RT-PCR. The expression of both the genes was significantly upregulated in both AAA and CAS compared with control regions as followed : IL-8=0.53±0.16 vs 0.11±0.04 (p<0.01); CXCR-2=2.04±0.75 vs 0.29±0.10 (p<0.01) in AAA, and IL-8=1.35±0.25 vs 0.60±0.16; CXCR-2=2.00±0.51 vs 0.58±0.21 (p<0.05) in CAS. Under these conditions, the gene expressions of monocyte chemotactic protein-1 and its receptor, CCR-2, were not significantly different in the control and diseased regions of both AAA and CAS. Conclusions Sustained upregulation of IL-8 and CXCR-2 was observed in both AAA and CAS, suggesting the inflammatory process is still active in established dilated and occlusive atherosclerotic diseases. Whether upregulation of this system could be protective or not protective for disease development requires further study.

• 社団法人日本循環器学会の論文
• 2005-11-20

著者

• TOMOIKE Hitonobu

  Division of Preventive Cardiology, National Cardiovascular Center

• Hayashi Tokio

  Department of Cardiology, National Cardiovascular Center

• Yamgishi Masakazu

  Department Of Organ Transplantation National Cardiovascular Center

• Yamagishi Masakazu

  Division Of Cardiology First Department Of Medicine Osaka University School Of Medicine

• Ogino Hitoshi

  Cardiovascular Surgery, National Cardiovascular Center

• Ogino Hitoshi

  Department Of Bioscience National Cardiovascular Center

• Ogino Hitoshi

  Department Of Cardiovascular Surgery National Cardiovascular Center

• Sasaki Hiroaki

  Department Of Cardiovascular Surgery National Cardiovascular Center

• Hayashi Tokio

  Department Of Cardiology National Cardiovascular Center

• Sakamoto Aiji

  Division of Biotechnology, National Cardiovacular Center Reserch Institute

• Ogino Hitoshi

  Department Of Cardiovascular Surgery

• Higashikata Takeo

  Biotechnology In Bioscience National Cardiovascular Center And Research Institute

• Sakamoto Aiji

  Division Of Biotechnology National Cardiovacular Center Reserch Institute

• Ishibashi Hatsue

  Pathology, National Cardiovascular Center and Research Institute

• Sasaki Hiroaki

  Cardiovascular Surgery, National Cardiovascular Center and Research Institute

• Iihara Koji

  Neurosurgery, National Cardiovascular Center and Research Institute

• Miyamoto Susumu

  Neurosurgery, National Cardiovascular Center and Research Institute

• Nagaya Noritoshi

  Regenerative Medicine and Tissue Engineering, National Cardiovascular Center and Research Institute

• Sakamoto Aiji

  Biotechnology in Bioscience, National Cardiovascular Center and Research Institute

• Ogino Hitoshi

  Cardiovascular Surgery National Cardiovascular Center And Research Institute

• Ogino Hitoshi

  Cardiovascular Surgery National Cardiovascular Center

• Nagaya Noritoshi

  Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center Research I

• Sasaki Hiroaki

  Department Of Cardio-vascular Surgery National Cardio-vascular Center

• Tomoike Hitonibu

  Department Of Cardiology National Cardiovascular Center

• Ishibashi Hatsue

  Pathology National Cardiovascular Center And Research Institute

• Miyamoto Susumu

  Neurosurgery National Cardiovascular Center And Research Institute

• Iihara Koji

  Neurosurgery National Cardiovascular Center And Research Institute

• Nagaya Noritoshi

  Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center

• Tomoike Hitonobu

  Division Of Cardiovascular Medicine National Cardiovascular Center

• Nagaya Noritoshi

  Department Of Regenerative Medicine National Cardiovascular Center

• Yamagishi Masakazu

  Cardiology Division Of Medicine National Cardiovascular Center

• Yamagishi Masakazu

  Devision Of Cardiology National Caediovascular Center

• Nagaya Noritoshi

  Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center Research I

• Nagaya Noritoshi

  Regenerative Medicine And Tissue Engineering National Cardiovascular Center And Research Institute

• Nagaya Noritoshi

  Department Of Regenerative Medicine And Tissue Engineering National Cardiovascular Center Research I

• Nagaya Noritoshi

  Cardiovasclular Dynamics Dept National Cardiovascular Center

• Yamagishi Masakazu

  Division Of Cardiology Department Of Internal Medicine Kanazawa University Graduate School Of Medici

• Tomoike Hitonobu

  Division Of Cardiovascular Medicine

• Sasaki Hiroaki

  Department Of Cardiovascular Surgery National Cerebral And Cardiovascular Center

• TOMOIKE Hitonobu

  Division of Cardiology, Okayama University

関連論文

• Association of the Functional Variant in the 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Gene With Low-Density Lipoprotein-Cholesterol in Japanese
• Experience of appendicular thermal therapy applied to a patient with a left ventricular assist device awaiting heart transplantation
• A Genome-Wide Association Study of Hypertension-Related Phenotypes in a Japanese Population
• Identification of Genetic Markers Associated With High-Density Lipoprotein-Cholesterol by Genome-Wide Screening in a Japanese Population : The Suita Study
• Impact of Severe Earthquake on the Occurrence of Acute Coronary Syndrome and Stroke in a Rural Area of Japan : Experience From the Noto Peninsula Earthquake
• Genetic Variations and Haplotypes of UGT1A4 in a Japanese Population
• Genetic Polymorphisms of UGT1A6 in a Japanese Population
• Single Nucleotide Polymorphisms and Haplotypes of CYP1A2 in a Japanese Population
• Genetic Variations of the AHR Gene Encoding Aryl Hydrocarbon Receptor in a Japanese Population
• PJ-569 Long-term Results of Autologous Transplantation of Bone Marrow Mononuclear Cells for Patients with Thromboangiitis Obliterans(Peripheral circulation-6 (H) PJ96,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese
• Evaluation of Novel Micro-angiography for Clinical Therapeutic Angiogenesis(Angiogenesis 4 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• The strategy for type A retrograde thrombosed aortic dissection : comparison with type A aortic intramural hematoma
• Twenty-six Novel Single Nucleotide Polymorphisms and their Frequencies of the NR113 (CAR) Gene in a Japanese Population
• PJ-651 Predictors of the Improvement in Left Ventricular Ejection Fraction in Non-Ischemic Dilated Cardiomyopathy during Beta-Blocker Therapy(PJ109,Heart Failure (Treatment) 3 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanes
• PJ-372 Systemic Vascular Resistance Guided Optimal Drug Selection in Patients with Acute Decompensated Heart Failure : A Validation Study(PJ063,Heart Failure (Treatment) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
• PE-357 Does Preoperative Left Atrial Dilatation Predict Adverse Events after Aortic Valve Replacement?(PE060,Valvular Heart Disease (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-254 "Cardiac Anemia" is an Independent Predictor of Prognosis in Patients with Non-Ischemic Chronic Heart Failure(PE043,Heart Failure (Biomarker) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-034 Negative Impact of Cardio-renal Anemia Syndrome on Beta-blocker Tolerance and Subsequent Major Adverse Cardiac Events in Chronic Heart Failure(PE006,Kidney/Renal Circulation/CKD 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of T
• 2 Present Strategy for the Treatment of Profound Heart Failure : Long-term Support by Left Ventricular Assist Systems and Heart Transplantation(Therapeutic Strategy for Severe Heart Failure-From LVAD to Heart Transplantation-,Symposium 11 (SY-11) (H),The
• OE-352 The Preoperative Cardio-Renal-Anemia-Syndrome and Myocardial Fibrosis Have Negative Impact on Survival and Myocardial Recovery After Left Ventricular Assist Device Implantation(Heart failure, clinical(04)(M),Oral Presentation(English),The 72nd Annu
• OE-362 Genome-wide Search for Polymorphic Markers Associated with Lipid and Blood Pressure Levels in Japanese(OE61,Lipid Disorders (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• FRS-149 Mutation Site-Specific Differences in Arrhythmic Risk and Sensitivity to Sympathetic Stimulation in Japanese Families with Congenital LQT1 Syndrome(Sudden Cardiac Death (A) : FRS18)(Featured Research Session (English))
• Hemodynamic and Echocardiographic Evaluation of Orthotopic Heart Transplantation With the Modified Bicaval Anastomosis Technique
• 2 Present Strategy for the Treatment of Profound Heart Failure : Long-term Support by Left Ventricular Assist Systems and Heart Transplantation(Therapeutic Strategy for Severe Heart Failure-From LVAD to Heart Transplantation-,Symposium 11 (SY-11) (H),The
• OE-352 The Preoperative Cardio-Renal-Anemia-Syndrome and Myocardial Fibrosis Have Negative Impact on Survival and Myocardial Recovery After Left Ventricular Assist Device Implantation(Heart failure, clinical(04)(M),Oral Presentation(English),The 72nd Annu
• OE-157 Clinical course and outcome of heart transplant recipients : single center' s experience at National Cardiovascular Center(Transplantation/LVAD (IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• 4 Cardiac rehabilitation in the management of patients with end-stage heart failure(Symposium 16 (SY-16) (H) Cardiac Rehabilitation : Innovative Approach to Improve Patient Care,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulatio
• 4 Long-term Use of Left Ventricular Assist System as a Bridge to Heart Transplant : Superior Survival Rate to REMATCH Trial(Symposium 8 (SY-08) (M) New Strategies for Management of Severe Heart Failure with New Devices and Surgery,Special Program,The 72nd
• PJ-569 Long-term Results of Autologous Transplantation of Bone Marrow Mononuclear Cells for Patients with Thromboangiitis Obliterans(Peripheral circulation-6 (H) PJ96,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese
• PE-502 Impact of Acceleration of Post-prandial Remnant Lipoprotein Clearance in Autosomal Recessive Hypercholesterolemia (ARH)(PE084,Lipid Disorders 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
• Clinical Significance of Plasma Brain Natriuretic Peptide as a Noninvasive Marker of Disease Severity in Aortic Regurgitation(Valvular Heart Disease/Pericarditis/Cardiac Tumor 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Preoperative Prediction of Myocardial Recovery by Left Ventricular Assist System(Frontier in Cardiovascular Surgery (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Insulin-like Growth Factor-1 Improves Cardiac Function and Symptoms in the Patients on the Waiting List for Transplantation with Dilated Cardiomyopathy(Clinical and Basic Research in Heart Failure (M), The 69th Annual Scientific Meeting of the Japanese Ci
• PJ-600 Coronary flow reserve by transthoracic Doppler ultrasound can detect noninvasively acute cardiac allograft rejection in heart transplant recipients.(Transplantation 2 (M) : PJ101)(Poster Session (Japanese))
• PJ-231 Can We Reduce β-Blockers to Half Doses in Patients With Stable Heart Failure during Long-term Administration of β-Blockers?(Heart Failure, Clinical 3 (M) : PJ39)(Poster Session (Japanese))
• Transmural Myocardial Strain Gradient : A New and Robust Index for Quantifying Myocardial Regional Systolic Function(Echo/Doppler 6 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Dyssynchrony Imaging, A New Method to Assess Left Ventricular Dyssynchrony Based on Myocardial Strain : Comparison With Traditional Tissue Velocity Method(Echo/Doppler 13 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• 4 Current Status and Surrounding Issues of Clinical Trials in Japan : Lesson and Proposal from our Experience of the Clinical Trials(Clinical Trials Update in Japan and Future Perspective, The 71st Annual Scientific Meeting of the Japanese Circulation Soc
• Association of Genetic Polymorphisms of Endothelin-Converting Enzyme-1 Gene with Hypertension in a Japanese Population and Rare Missense Mutation in Preproendothelin-1 in Japanese Hypertensives
• Association of Genetic Polymorphisms of Sodium-Calcium Exchanger 1 Gene, NCX1, with Hypertension in a Japanese General Population
• Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population
• Validation of the Association of Genetic Variants on Chromosome 9p21 and 1q41 With Myocardial Infarction in a Japanese Population
• Associations of Hypertension and Its Complications with Variations in the Xanthine Dehydrogenase Gene
• Single Nucleotide Polymorphisms in the Interleukin-6 Gene Associated with Blood Pressure and Atherosclerosis in a Japanese General Population
• 6 Experience of Large-Scale Trial Using ANP or Nicorandil as an Adjunct to Percutaneous Coronary Intervention for Acute Myocardial Infarction(New Horizon in Coronary Interventions for Acute Coronary Syndrome, The 71st Annual Scientific Meeting of the Japa
• FRS-079 Prevalence of Diastolic Left Ventricular Dysfunction in Asymptomatic Residents in Japanese Community(Clinical Heart Failure, Diagnosis and Treatment-1 (M) FRS16,Featured Research Session (English),The 70th Anniversary Annual Scientific Meeting of
• Difference between Fasting and Nonfasting Triglyceridemia ; the Influence of Waist Circumference
• Marked Aortic Valve Stenosis Progression After Receiving Long-Term Aggressive Cholesterol-Lowering Therapy Using Low-Density Lipoprotein Apheresis in a Patient With Familial Hypercholesterolemia
• PJ-540 Risk of Surgery after Coronary Drug-Eluting Stent Implantation(PJ091,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OE-354 Automated Function Imaging would be Correlated with Systolic and Diastolic Parameter of Conventional Echocardiography and Catheterization(Heart failure, clinical(04)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese C
• DPJ-054 Is Cardiac Rehabilitation Unnecessary in Low Prognostic Risk Patients with Acute Myocardial Infarction in the Primary Intervention Era?(DPJ09,Exercise Test/Cardiac Rehabilitation (H),Digital Poster Session (Japanese),The 73rd Annual Scientific Mee
• OJ-017 Determination of Ventricular Pacing Sites in Patients with Cardiac Resynchronization Therapy Using Tissue Tracking Imaging : Relevance to Prediction of Responders(Echo/Doppler-3 (I) OJ3,Oral Presentation (Japanese),The 70th Anniversary Annual Scien
• FRS-027 Diastolic Untwisting is Delayed in Chronic Mitral Regurgitation(Recent Advance in Echocardiography-1 (I) FRS6,Featured Research Session,The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PE-396 Impact of New Insights of Lipoprotein Metabolism in Autosomal Recessive Hypercholesterolemia : A Stable Isotope Kinetic Study in Vivo(PE067,Lipid Disorders 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulatio
• FRS-117 Clinical and Electrocardiographic Characteristics of Japanese Probands with Brugada Syndrome with an SCN5A Mutation from Japanese Multicenter Registry(FRS24,Novel Mechanisms of Ventricular Arrhythmia (A),Featured Research Session (English),The 73r
• PJ-813 Impact of Speckle Tracking Echocardiography on Evaluation of Myocardial Fibrosis in Hypertrophic Cardiomyopathy : Comparison with Study by Cardiovascular Magnetic Resonance(PJ136,Echo/Doppler (Others) 1 (I),Poster Session (Japanese),The 73rd Annual
• PJ-433 Impact of the HERG Channel Activator "Malltoxin" on Type 2 LQTS Related Mutant Channel(PJ073,Arrhythmia, Others (Basic) 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• 3 Application of Newly Developed Intravascular Ultrasound Elastography for Quantitative Tissue Characterization of Human Coronary Plaques(New Evidence of Coronary Artery Disease-Pathogenesis, Diagnosis and Therapy, The 71st Annual Scientific Meeting of th
• PE-046 Expression of Ephrin-B1/EphB2 in Human Atherosclerotic Tissues : New Insights into Mechanisms of Macrophage-lymphocyte Interaction(Atherosclerosis, basic-3 (H) PE8,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japan
• Role of Echocardiography in Assessing Pregnant Women With and Without Heart Disease
• Usefulness of Three-Dimensional Echocardiography for Assessment of Atrial Septal Defect : Comparison to Surgical Findings
• PE-060 Echocardiographic Signs of Pericardial Constriction as Predictors of Maternal Heart Failure in pregnant Women after Open Heart Surgery(Echo/Doppler-08, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• FRS-095 Enhanced Method for Intravascular Ultrasound Evaluation of Coronary Plaque by Combining Elastography with Integrated Backscatter Tissue Analyses(Visualization of Atherosclerotic Plaque (I) FRS19,Featured Research Session (English),The 70th Anniver
• PJ-274 A New Device for Transluminal Removal of Expanded Vascular Stent : an in Vivo Feasibility Study(PJ046,Coronary Revascularization, PCI (New Devices/New Technology) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
• PE-516 Limited Long-term Efficacy of Endovascular Intervention in Patients with Superficial Femoral Artery Lesions(Peripheral circulation-3 (H) PE87,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Societ
• PJ-032 Clinical Significance and Limitation of Myocardial Washout Rate of Tc-99m-sestamibi in Left Ventricular Remodeling in Patients With Chronic Heart Failure(Nuclear Cardiology 2 (I) : PJ6)(Poster Session (Japanese))
• Cardiac Tumor as an Initial Manifestation of Acquired Immunodeficiency Syndrome
• OE-155 Reduced Left Ventricular Torsion with Two-Dimensional Speckle Tracking Echocardiography would Predict Acute Rejection in Heart Transplant Recipients.(Transplantation/LVAD (IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Ja
• Successful Excision of a Cystic Tumor of the Atrioventricular Nodal Region
• PJ-260 Triglyceride-rich Lipoprotein Cholesterol Abnormalities of Familial Hypercholesterolemia : An Ultracentrifugation Analysis(PJ044,Atherosclerosis (Clinical/Diagnosis) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japane
• PE-093 The Carotid Intima-media Thickness of Young Familial Hypercholesterolemia (FH) is Greater than Non-FH Littermates(PE016,Atherosclerosis (Clinical/Diagnosis) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulati
• OE-154 Cardiac Sarcoidosis in Japanese Heart Transplant Patients(Transplantation/LVAD (IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Sustained Upregulation of Inflammatory Chemokine and Its Receptor in Aneurysmal and Occlusive Atherosclerotic Disease : Results From Tissue Analysis With cDNA Macroarray and Real-Time Reverse Transcriptional Polymerase Chain Reaction Methods
• Expression of Reversion-Inducing Cysteine-Rich Protein With Kazal Motifs (RECK), a Potent Matrix Metalloproteinase Inhibitor, in Human Atherosclerotic Plaque (Atherosclerosis, Basic 7 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation S
• The role of a common TNNT2 polymorphism in cardiac hypertrophy
• PJ-443 Impact of Primary Aldosteronism on Occurrence of Atrial Fibrillation and Cerebral Events(PJ075,Hypertension, Clinical 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-505 Differences in Clinical Profiles of Patients with Thoracic vs Abdominal Aortic Aneurysms(Cardiovascular surgery/CABG-2 (IHD) PJ85,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-503 Increased FDP is an Independent Predictor of Adverse Late Outcomes in Patients with Acute Type B Aortic Dissection(Cardiovascular surgery/CABG-2 (IHD) PJ85,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Cir
• 3 Functional Significance of Altered Expression Balance of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases Genes in Carotid Plaque Rupture(Symposium 4 (SY4) (IHD) : Molecular Mechanism of Atherosclerosis)(Special Program)
• 4 Sustained Upregulation of Cytokine and Proteinase Genes in Dilated and Occlusive Atherosclerotic Disease : Results from cDNA Array and Real-time RT-PCR(Plenary Session 2 (PL2) (IHD) : Inflammation and Atherosclerosis : From Bench to Bedside)(Special Pro
• Rationale for the Use of Combination Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Therapy in Heart Failure
• Aldehyde Dehydrogenase 2 Gene Is a Risk Factor for Myocardial Infarction in Japanese Men
• PE-118 Discrepancy between Electrocardiographic Type of Intraventricular Conduction Disturbances and Area of Mechanical Dyssynchrony : Assessment with Tissue Synchronization Imaging(Echo/Doppler 4 (I) : PE20)(Poster Session (English))
• OJ-086 Prediction of Exercise Capacity in Patients with Dilated Cardiomyopathy by a Combination of Pulsed and Strain Doppler Echocardiography(Echo/Doppler 1 (I) : OJ11)(Oral Presentation (Japanese))
• Association of Sixty-One Non-Synonymous Polymorphisms in Forty-One Hypertension Candidate Genes with Blood Pressure Variation and Hypertension
• Genetic Variations of HSD11B2 in Hypertensive Patients and in the General Population, Six Rare Missense/Frameshift Mutations
• A Novel Missense Mutation, F826Y, in the Mineralocorticoid Receptor Gene in Japanese Hypertensives : Its Implications for Clinical Phenotypes
• PE-115 Reduced Coronary Flow Velocity Reserve of Left Anterior Descending Artery Under Right Coronary Artery Lesion : Impact of Coronary Steal Phenomenon(Echo/Doppler 4 (I) : PE20)(Poster Session (English))
• Is the Pathogenesis of Aortic Aneurysm Different between Abdominal and Thoracic Aneurysms? (Atherosclerosis, Clinical 7 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Hyperconsumptive Coagulopathy Persists in Patient with Dilated Aortic Intramural Hematoma(Peripheral Circulation/Vascular Disease 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-187 Clinical Features of Penetrating Atherosclerotic Ulcer : Atypical or/and Silent Aortic Dissection?(Peripheral Circulation/Vascular Disease 1 (H) : OJ21)(Oral Presentation (Japanese))
• 2 Future Challenge in Brugada syndrome : Gender and Ethnic Differences(Brugada Syndrome:From Cell to Bedside,Plenary Session 2 (PL2) (A),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-243 A Novel Mutation in the Autosomal Recessive Hypercholesterolemia Gene Leads to Hypercholesterolemia(Lipid disorders-3 (H) PJ41,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• 4 Pharmacogenomic Approaches Targeted on the Tailor-made Medicine for Hypertension(Plenary Session 7 (PL-7) (M) Genomic Approaches to Cardiovascular Diseases : Present and Future,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulati
• Lesion Severity and Hypercholesterolemia Determine Long-Term Prognosis of Vasospastic Angina Treated With Calcium Channel Antagonists
• A Genome-Wide Association Study of Hypertension-Related Phenotypes in a Japanese Population
• Impact of Renin-Angiotensin System Polymorphisms on Development of Systolic Dysfunction in Hypertrophic Cardiomyopathy : Evidence From a Study of Genotyped Patients
• Efficacy of Out-Patient Cardiac Rehabilitation in Low Prognostic Risk Patients After Acute Myocardial Infarction in Primary Intervention Era
• Impact of reduced left atrial functions on diagnosis of paroxysmal atrial fibrillation : Results from analysis of time-left atrial volume curve determined by two-dimensional speckle tracking
• Unusual biatrial thrombus in mitral stenosis

もっと見る 閉じる

スポンサーリンク