4 Current Status and Surrounding Issues of Clinical Trials in Japan : Lesson and Proposal from our Experience of the Clinical Trials(Clinical Trials Update in Japan and Future Perspective, The 71st Annual Scientific Meeting of the Japanese Circulation Soc

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概要

• 論文の詳細を見る
• 社団法人日本循環器学会の論文
• 2007-03-01

著者

• KITAKAZE Masafumi

  Division of Cardiology, National Cardiovascular Center

• TOMOIKE Hitonobu

  Division of Preventive Cardiology, National Cardiovascular Center

• Abe Hiroshi

  Department Of Cardiology National Cardiovascular Center

• Kitakaze Masafumi

  Division Of Cardiology National Cardiovascular Center

• Kitakaze Masafumi

  Nagoya University Graduate School Of Medicine

• Tomoike Hitonobu

  国立循環器病センター 疫学部

• Kim Chijun

  Department Of Cardiology National Cardiovascular Center

• Kimu Chiyun

  Division Of Cardiology National Cardiovascular Center

• Asakura Masanori

  Division of Cardiology, National Cardiovascular Center

• Ohara Takahiro

  Division of Cardiology, National Cardiovascular Center

• Asanuma Hiroshi

  Division of Cardiovascular Medicine, National Cardiovascular Center

• Abe Hiroshi

  Cardiovascular Division Osaka Minami Medical Center

• Asanuma Hiroshi

  Departments Of Cardiology Chubu Rosai Hospital

• Asanuma Hiroshi

  Department Of Cardiology National Cardiovascular Center

• Asano Hiroyuki

  Departments Of Cardiology Chubu Rosai Hospital

• Amemiya Hiroshi

  Dept. Of Radiology And Surgical Research National Cardiovascular Center

• Tomoike Hitonobu

  Able Corporation:department Of Biotechnology School Of Engineering Nagoya University

• Tomoike Hitonibu

  Department Of Cardiology National Cardiovascular Center

• Abe H

  Institute Of Symbiotic Science And Technology Tokyo University Of Agriculture And Technology

• Tomoike Hitonobu

  Division Of Cardiovascular Medicine National Cardiovascular Center

• Abe H

  Department Of Cardiology National Cardiovascular Center

• Asakura Masanori

  Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center

• Takeda Hideo

  Department Of Preventive Medicine Institute Of Health Biosciences The University Of Tokushima Gradua

• TOMOIKE Hitonobu

  Sakakibara Heart Institute

• Tomoike Hitonobu

  Division Of Cardiovascular Medicine

関連論文

• Association of the Functional Variant in the 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Gene With Low-Density Lipoprotein-Cholesterol in Japanese
• Experience of appendicular thermal therapy applied to a patient with a left ventricular assist device awaiting heart transplantation
• A Genome-Wide Association Study of Hypertension-Related Phenotypes in a Japanese Population
• Identification of Genetic Markers Associated With High-Density Lipoprotein-Cholesterol by Genome-Wide Screening in a Japanese Population : The Suita Study
• Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
• Genetic Variations and Haplotypes of UGT1A4 in a Japanese Population
• Genetic Polymorphisms of UGT1A6 in a Japanese Population
• Single Nucleotide Polymorphisms and Haplotypes of CYP1A2 in a Japanese Population
• Genetic Variations of the AHR Gene Encoding Aryl Hydrocarbon Receptor in a Japanese Population
• Three Novel Single Nucleotide Polymorphisms in UGT1A9
• Twenty-six Novel Single Nucleotide Polymorphisms and their Frequencies of the NR113 (CAR) Gene in a Japanese Population
• Usefulness of three-dimensional echocardiography in assessing right ventricular function in patients with primary pulmonary hypertension
• PJ-504 Aortic Pulse Wave Velocity can Predict Left Ventricular Diastolic Dysfunction in a Community-based Population(PJ085,Heart Failure (Pathophysiology) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
• 5 A Role of Endoplasmic Reticulum Stress in the Pathophysiology of Atherosclerotic Plaques Associated with Acute Coronary Syndrome(Vulnerable Patient/Vulnerable Plaque in Acute Coronary Syndrome,Plenary Session 2 (PL-2) (H),The 73rd Annual Scientific Meet
• Inhibition of Cardiac Remodeling by Pravastatin Is Associated with Amelioration of Endoplasmic Reticulum Stress
• Plasma Adiponectin Is Associated with Plasma Brain Natriuretic Peptide and Cardiac Function in Healthy Subjects
• PJ-763 Improvement of Left Ventricular Ejection Fraction is a Predictor for Cardiac Events in Patients with Acute Myocardial Infarction(Acute myocardial infarction, clinical(diagnosis / treatment)(12)(IHD),Poster Session(Japanese),The 72nd Annual Scientif
• PJ-308 Miglitol, a Novel Alpha-Glucosidase Inhibitor, Improves Left Ventricular Function in Dogs With Pacing-Induced Heart Failure(Heart failure, basic(06)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-110 Transmural Heterogeneity of Global Gene Expression Profiles in Canine Failing Ventricular Myocardium(Heart failure, basic(05)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-091 Activation of AMP-activated Protein Kinase by Metformin Prevents Progression of Heart Failure in Dogs(Heart failure, basic(02)(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-362 Genome-wide Search for Polymorphic Markers Associated with Lipid and Blood Pressure Levels in Japanese(OE61,Lipid Disorders (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-504 Aortic Pulse Wave Velocity can Predict Left Ventricular Diastolic Dysfunction in a Community-based Population(PJ085,Heart Failure (Pathophysiology) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
• PE-482 Does Assessment of Atrial Contractile Properties Predict Paroxysmal Atrial Fibrillation? : A Color Doppler Strain Rate Imaging Study(PE081,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 4 (A),Poster Session (English),The 73rd Annual Scientific M
• OE-128 Left Ventricular Global Strain and Dyssynchrony Demonstrated by Speckle Tracking Echocardiography : A Comparison of Apical and Septal Right Ventricular Pacing(OE22,Echo/Doppler (Myocardium) (I),Oral Presentation (English),The 73rd Annual Scientific
• 5 A Role of Endoplasmic Reticulum Stress in the Pathophysiology of Atherosclerotic Plaques Associated with Acute Coronary Syndrome(Vulnerable Patient/Vulnerable Plaque in Acute Coronary Syndrome,Plenary Session 2 (PL-2) (H),The 73rd Annual Scientific Meet
• PJ-763 Improvement of Left Ventricular Ejection Fraction is a Predictor for Cardiac Events in Patients with Acute Myocardial Infarction(Acute myocardial infarction, clinical(diagnosis / treatment)(12)(IHD),Poster Session(Japanese),The 72nd Annual Scientif
• PJ-218 Bachmann's Bundle Pacing Gets an Advantage over Right Atrial Appendage Pacing on Atrial Contraction Synchrony : A Strain Rate Imaging Study(Arrhythmia, therapy(24)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circu
• OJ-247 Influence of Preload Changes Mediated by Upper Body Tilting Position on Left Ventricular Diastolic Indices in chronic heart failure subjects(Echo / Doppler(04)(I),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circu
• 3 Management of Hyperphosphatemia is an Important Novel Therapeutic Target in Chronic Heart Failure(Symposium 11 (SY-11) (M) Stroke and Cardiorenal Complications in Hypertension,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulatio
• 3 Potential Pharmacological Adjunctive Therapy for Acute Myocardial Infarction : Lessons from J-WIND trials(Plenary Session 2 (PL-2) (IHD) Myocardial Protection Strategy after Reperfusion Therapy in Acute Coronary Syndrome,Special Program,The 72nd Annual
• Atorvastatin Slows the Progression of Cardiac Remodeling in Mice with Pressure Overload and Inhibits Epidermal Growth Factor Receptor Activation
• Long-Term Oral Administration of Dipyridamole Improves Both Cardiac and Physical Status in Patients with Mild to Moderate Chronic Heart Failure : A Prospective Open-Randomized Study
• Impact of Adenosine Receptor Signaling and Metabolism on Pathophysiology in Patients with Chronic Heart Failure
• PE-342 Novel Point-of-Care Test for Oxidative Stress, ROM Test, Reflects Elevated Oxidation Levels in the Patients with Chronic Heart Failure(Heart failure, clinical-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-250 A Novel Role of Histamine H2 Receptors in the Pathophysiology of Canine Heart Failure Induced by Sustained Rapid Pacing(Heart failure, basic-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• FRS-092 Chronic Stimulation of Adenosine A2b Receptors Begun after Myocardial Infarction Prevents Cardiac Remodeling in Rats(Heart Failure, Cardiac Remodeling and Cardiomyopathy 2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-334 Measurement of the Plasma Adiponectin Level is Useful for the Prediction of Metabolic Syndrome : Result from KING Study(PJ056,Preventive Medicine/Epidemiology/Education 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japan
• PJ-197 Common Variants in and around the Adiponectin Gene Associated with Plasma Adiponectin Level : Result from KING Study(PJ033,Preventive Medicine/Epidemiology/Education 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
• PJ-192 Genetic Determinants of Plasma Resistin Levels in a Japanese Aged Cohort (KING Study)(PJ033,Preventive Medicine/Epidemiology/Education 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-231 Can We Reduce β-Blockers to Half Doses in Patients With Stable Heart Failure during Long-term Administration of β-Blockers?(Heart Failure, Clinical 3 (M) : PJ39)(Poster Session (Japanese))
• Beta-Blocker Therapy in Patients with Dilated Cardiomyopathy : Different Effects on Heart Rate and the Role of the Selectivity of Beta-Blockers
• Heart Failure Elevates Serum Levels of Cibenzoline in Arrhythmic Patients(CLINICAL INVESTIGATION)
• Comparison of the Effects of Telmisartan and Olmesartan on Home Blood Pressure, Glucose, and Lipid Profiles in Patients with Hypertension, Chronic Heart Failure, and Metabolic Syndrome
• Dyssynchrony Imaging, A New Method to Assess Left Ventricular Dyssynchrony Based on Myocardial Strain : Comparison With Traditional Tissue Velocity Method(Echo/Doppler 13 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• 4 Current Status and Surrounding Issues of Clinical Trials in Japan : Lesson and Proposal from our Experience of the Clinical Trials(Clinical Trials Update in Japan and Future Perspective, The 71st Annual Scientific Meeting of the Japanese Circulation Soc
• PJ-047 The Combined Therapy of Angiotensin Converting Enzyme Inhibitor, Angiotensin II Receptor Blocker and Beta-blockers Submaximally Limits Infarct Size(Acute Myocardial Infarction, Basic 2 (IHD) : PJ8)(Poster Session (Japanese))
• PJ-046 Celiprolol, a Selective β_1-Adrenoceptor Antagonist, Limits Infarct Size via NO-dependent Mechanisms(Acute Myocardial Infarction, Basic 2 (IHD) : PJ8)(Poster Session (Japanese))
• Association of Genetic Polymorphisms of Endothelin-Converting Enzyme-1 Gene with Hypertension in a Japanese Population and Rare Missense Mutation in Preproendothelin-1 in Japanese Hypertensives
• Association of Genetic Polymorphisms of Sodium-Calcium Exchanger 1 Gene, NCX1, with Hypertension in a Japanese General Population
• Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population
• Validation of the Association of Genetic Variants on Chromosome 9p21 and 1q41 With Myocardial Infarction in a Japanese Population
• Associations of Hypertension and Its Complications with Variations in the Xanthine Dehydrogenase Gene
• Single Nucleotide Polymorphisms in the Interleukin-6 Gene Associated with Blood Pressure and Atherosclerosis in a Japanese General Population
• Role of Transthoracic Doppler-Determined Coronary Flow Reserve in Patients With Chest Pain
• 6 Experience of Large-Scale Trial Using ANP or Nicorandil as an Adjunct to Percutaneous Coronary Intervention for Acute Myocardial Infarction(New Horizon in Coronary Interventions for Acute Coronary Syndrome, The 71st Annual Scientific Meeting of the Japa
• The ATP-sensitive Potassium Channel Opener, Nicorandil, Reduces No-reflow Phenomenon and Infarct Size in the Canine Heart
• OE-354 Automated Function Imaging would be Correlated with Systolic and Diastolic Parameter of Conventional Echocardiography and Catheterization(Heart failure, clinical(04)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese C
• PJ-027 What Does Electrocardiographic Strain Pattern Mean in Aortic Stenosis? : Assessment With Myocardial Tissue Strain Imaging(Echo/Doppler 3 (I) : PJ5)(Poster Session (Japanese))
• Nano-size liposome coated with polyethylene glycol can deliver drugs to ischemia/reperfused myocardium(Additional Remarks, Plenary Session 2 (PL-2) (IHD) Myocardial Protection Strategy after Reperfusion Therapy in Acute Coronary Syndrome,Special Program,T
• PE-046 Expression of Ephrin-B1/EphB2 in Human Atherosclerotic Tissues : New Insights into Mechanisms of Macrophage-lymphocyte Interaction(Atherosclerosis, basic-3 (H) PE8,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japan
• Heterogeneous contraction of the left ventricle demonstrated by 2-dimensional strain imaging
• PJ-032 Clinical Significance and Limitation of Myocardial Washout Rate of Tc-99m-sestamibi in Left Ventricular Remodeling in Patients With Chronic Heart Failure(Nuclear Cardiology 2 (I) : PJ6)(Poster Session (Japanese))
• Patients With Dilated Cardiomyopathy With Attenuated Elevation of Cardiac Sympathetic Activity are Poor Responder to Carvedilol Therapy
• Prognostic Significance of Cardiac Metaiodobenzylguanidine Uptake and Plasma BNP Concentrations before The Carvedilol Therapy in Patients with Chronic Heart Failure
• Angiotensin Converting Enzyme Inhibitor Reduces Cardiac Hypertrophy and Fibrosis in Cardiomyopathic Hamsters via NO-dependent Mechanisms(Heart Failure, Basic 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Left Ventricular Diastolic Flow Propagates Into the Ventricle Not Linearly But Curvilinearly : Temporal Analysis of Propagation Velocity by Trajectory Imaging
• PJ-092 Activation of Adenosine A1 Receptors Inhibits Aldosterone Synthesis in Adrenal Glands(Metabolism/Biochemistry/Energetics-3 (M) PJ16,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PE-256 Feasibility of Transthoracic Doppler-determined Coronary Flow Reserve for the Assessment of Left Main Trunk Stenosis(Echo/Doppler-10 (I) PE43,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Societ
• OE-154 Cardiac Sarcoidosis in Japanese Heart Transplant Patients(Transplantation/LVAD (IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Sustained Upregulation of Inflammatory Chemokine and Its Receptor in Aneurysmal and Occlusive Atherosclerotic Disease : Results From Tissue Analysis With cDNA Macroarray and Real-Time Reverse Transcriptional Polymerase Chain Reaction Methods
• OJ-020 Oxidative Stress-induced Decline of Proteasome Activity Promotes Accumulation of Proapoptotic Proteins and Contributes to Cardiomyocytes Apoptosis in Failing Heart(Heart failure, basic-2 (M) OJ4,Oral Presentation (Japanese),The 70th Anniversary Ann
• 3 Functional Significance of Altered Expression Balance of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases Genes in Carotid Plaque Rupture(Symposium 4 (SY4) (IHD) : Molecular Mechanism of Atherosclerosis)(Special Program)
• 4 Sustained Upregulation of Cytokine and Proteinase Genes in Dilated and Occlusive Atherosclerotic Disease : Results from cDNA Array and Real-time RT-PCR(Plenary Session 2 (PL2) (IHD) : Inflammation and Atherosclerosis : From Bench to Bedside)(Special Pro
• Aldehyde Dehydrogenase 2 Gene Is a Risk Factor for Myocardial Infarction in Japanese Men
• DNA array for the discovery of genes related to cardiovascular disease and SNP for its application to the large-scale clinical trials
• A Selective Estrogen Receptor Modulator, Raloxifene, Inhibits the Cardiac Hypertrophy and Dysfunction due to Aortic Banding in Mice
• FRS-184 Investigation of Gene Regulatory Mechanisms Governing Myocardial Energy Metabolism and the Effects of β-Blocker Therapy in Patients with Heart Failure(Heart Failure : Basic and Clinical Viewpoint (M) : FRS22)(Featured Research Session (English))
• Changes in myocardial gene expression associated with betablocker therapy in patients with chronic heart failure
• Altered gene expression of calcium regulatory protein in patients with chronic heart failure
• PE-118 Discrepancy between Electrocardiographic Type of Intraventricular Conduction Disturbances and Area of Mechanical Dyssynchrony : Assessment with Tissue Synchronization Imaging(Echo/Doppler 4 (I) : PE20)(Poster Session (English))
• OJ-086 Prediction of Exercise Capacity in Patients with Dilated Cardiomyopathy by a Combination of Pulsed and Strain Doppler Echocardiography(Echo/Doppler 1 (I) : OJ11)(Oral Presentation (Japanese))
• Visualization of Ventricular Contraction Sequence by Tissue Tracking Technique : A New Echocardiographic Technique for Evaluating Myocardial Tissue Displacement
• Association of Sixty-One Non-Synonymous Polymorphisms in Forty-One Hypertension Candidate Genes with Blood Pressure Variation and Hypertension
• Genetic Variations of HSD11B2 in Hypertensive Patients and in the General Population, Six Rare Missense/Frameshift Mutations
• A Novel Missense Mutation, F826Y, in the Mineralocorticoid Receptor Gene in Japanese Hypertensives : Its Implications for Clinical Phenotypes
• PE-115 Reduced Coronary Flow Velocity Reserve of Left Anterior Descending Artery Under Right Coronary Artery Lesion : Impact of Coronary Steal Phenomenon(Echo/Doppler 4 (I) : PE20)(Poster Session (English))
• Rho-kinase Inhibitiors Administered After the Onset of Reperfusion Limit Infarct Size : A Novel Strategy for Adjunctive Therapies Against Myocardial Infarction
• A Role of Transient Preischemic Activation of Protein Kinase-A in Ischemic Preconditioning in Vivo : Involvement of p38 Mitogen-activated Protein Kinase
• PE-340 International Comparison of Clinical Use of Inotrope and Vasodilator Therapy for Acute Decompensated Heart Failure(Heart failure, clinical(10)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Amlodipine Increases Coronary Blood Flow and Reduces the Severity of Myocardial Ischemia in Canine Hearts : The Role of NO and Adenosine
• Inhibitory Effects of the CP Compound on Coronary Thromboemboli Caused by an Inhibition of Adenosine Receptors during Coronary Hypoperfusion
• 2 Future Challenge in Brugada syndrome : Gender and Ethnic Differences(Brugada Syndrome:From Cell to Bedside,Plenary Session 2 (PL2) (A),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-243 A Novel Mutation in the Autosomal Recessive Hypercholesterolemia Gene Leads to Hypercholesterolemia(Lipid disorders-3 (H) PJ41,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PE-193 The Effect of Noninvasive Positive Pressure Ventilation on Treatment of Patients with Flash Pulmonary Edema Admitted to the Emergency Department(Heart failure, clinical(08)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japane
• The Long-acting Calcium Channel Blockers Attenuate Cardiac Hypertrophy Induced by Chronic NO Inhibition : The Investigation of the Potential Subcellular Mechanisms
• 4 Pharmacogenomic Approaches Targeted on the Tailor-made Medicine for Hypertension(Plenary Session 7 (PL-7) (M) Genomic Approaches to Cardiovascular Diseases : Present and Future,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulati
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• A Genome-Wide Association Study of Hypertension-Related Phenotypes in a Japanese Population
• Are the Histological Improvements Operated by Beta-Blocker Therapy in Patients with Dilated Cardiomyopathy?
• Impact of reduced left atrial functions on diagnosis of paroxysmal atrial fibrillation : Results from analysis of time-left atrial volume curve determined by two-dimensional speckle tracking

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