DNA array for the discovery of genes related to cardiovascular disease and SNP for its application to the large-scale clinical trials
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概要
- 論文の詳細を見る
- 社団法人日本循環器学会の論文
- 2002-03-31
著者
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TAKASHIMA Seiji
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
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KITAKAZE Masafumi
Division of Cardiology, National Cardiovascular Center
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Kitakaze Masafumi
Division Of Cardiology National Cardiovascular Center
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ASAKURA Masanori
Department of Research and Development of Clinical Research, National Cardiovascular Center
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Shimazu Takashi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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NAKAMARU Kenji
Biomedical Research Laboratories, Sankyo Co. Ltd.
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ISOMURA Tadashi
Hayama Heart Center
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FURUKAWA Hidehiko
Biomedical Research Laboratories, Sankyo Co. Ltd.
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Furukawa Hidehiko
Biomedical Research Laboratories Sankyo Co. Ltd.
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Nakamaru Kenji
Biomedical Research Laboratories Sankyo Co. Ltd.
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Matsuura Kaoru
国立循環器病センター
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Takashima Seiji
Department Of Cardiology Osaka University Graduate School Of Medicine
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Takashima Seiji
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Nakamaru Kenji
Sankyo Co. Ltd.
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Koishi Ryuta
Sankyo Co. Ltd.
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Furukawa Hidehiko
Sankyo Co. Ltd.
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Asakura Masanori
Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center
関連論文
- Experience of appendicular thermal therapy applied to a patient with a left ventricular assist device awaiting heart transplantation
- Up-Regulation of Cell Adhesion Molecule Genes in Human Endothelial Cells Stimulated by Lymphotoxin Alpha : DNA Microarray Analysis
- PJ-225 Lymphotoxin-alpha Regulates Monocyte Adhesion to Endothelial Cells by Up-regulation of Cell Adhesion Molecules via PI3K-Akt-NFkB Pathway in Human Endothelial Cells(Atherosclerosis, basic(06)(IHD),Poster Session(Japanese),The 72nd Annual Scientific
- Genetic Variations and Haplotypes of ABCC2 Encoding MRP2 in a Japanese Population
- Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences
- Genetic Variations of the ABC Transporter Gene ABCB11 Encoding the Human Bile Salt Export Pump (BSEP) in a Japanese Population
- 日本人におけるGSTT1及びGSTM1の遺伝子多型の同定及びハプロタイプ構造の解析
- Twenty Novel Genetic Variations and Haplotype Structures of the DCK Gene Encoding Human Deoxycytidine Kinase (dCK)
- Genetic Variations of VDR/NR1I1 Encoding Vitamin D Receptor in a Japanese Population
- Genetic Variations and Frequencies of Major Haplotypes in SLCO1B1 Encoding the Transporter OATP1B1 in Japanese Subjects : SLCO1B1^*17 is More Prevalent Than ^*15
- Genetic Variations and Haplotype Structures of the ABC Transporter Gene ABCC1 in a Japanese Population
- 日本人における Denaturing HPLC を用いた Thiopurine S-Methyltransferase 遺伝子の新規SNPスクリーニング
- 日本人におけるヒトSLC29A1の新規遺伝子多型の同定
- Genetic Variation and Haplotype Structure of the ABC Transporter Gene ABCG2 in a Japanese Population
- Genetic Variations and Haplotypes of UGT1A4 in a Japanese Population
- Genetic Polymorphisms of UGT1A6 in a Japanese Population
- Single Nucleotide Polymorphisms and Haplotypes of CYP1A2 in a Japanese Population
- Genetic Variations of the AHR Gene Encoding Aryl Hydrocarbon Receptor in a Japanese Population
- PJ-225 Lymphotoxin-alpha Regulates Monocyte Adhesion to Endothelial Cells by Up-regulation of Cell Adhesion Molecules via PI3K-Akt-NFkB Pathway in Human Endothelial Cells(Atherosclerosis, basic(06)(IHD),Poster Session(Japanese),The 72nd Annual Scientific
- Three Novel Single Nucleotide Polymorphisms in UGT1A9
- Twenty-six Novel Single Nucleotide Polymorphisms and their Frequencies of the NR113 (CAR) Gene in a Japanese Population
- Japan Expects Decrements in Both the Incidence and Mortality of Acute Myocardial Infarction in the Modern Era : Likely or Just a Dream?
- Usefulness of three-dimensional echocardiography in assessing right ventricular function in patients with primary pulmonary hypertension
- PJ-651 Predictors of the Improvement in Left Ventricular Ejection Fraction in Non-Ischemic Dilated Cardiomyopathy during Beta-Blocker Therapy(PJ109,Heart Failure (Treatment) 3 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanes
- PJ-504 Aortic Pulse Wave Velocity can Predict Left Ventricular Diastolic Dysfunction in a Community-based Population(PJ085,Heart Failure (Pathophysiology) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
- PJ-489 Intraventricular Septal Intramural Asynchrony in Patients with Dilated Cardiomyopathy Using Tissue Velocity Imaging Correlates with the Severity of Myocardial Fibrosis(PJ082,Echo/Doppler (Myocardium) (I),Poster Session (Japanese),The 73rd Annual Sc
- PJ-372 Systemic Vascular Resistance Guided Optimal Drug Selection in Patients with Acute Decompensated Heart Failure : A Validation Study(PJ063,Heart Failure (Treatment) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
- PE-357 Does Preoperative Left Atrial Dilatation Predict Adverse Events after Aortic Valve Replacement?(PE060,Valvular Heart Disease (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-254 "Cardiac Anemia" is an Independent Predictor of Prognosis in Patients with Non-Ischemic Chronic Heart Failure(PE043,Heart Failure (Biomarker) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Inhibition of Cardiac Remodeling by Pravastatin Is Associated with Amelioration of Endoplasmic Reticulum Stress
- Atorvastatin Slows the Progression of Cardiac Remodeling in Mice with Pressure Overload and Inhibits Epidermal Growth Factor Receptor Activation
- PE-342 Novel Point-of-Care Test for Oxidative Stress, ROM Test, Reflects Elevated Oxidation Levels in the Patients with Chronic Heart Failure(Heart failure, clinical-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-092 Chronic Stimulation of Adenosine A2b Receptors Begun after Myocardial Infarction Prevents Cardiac Remodeling in Rats(Heart Failure, Cardiac Remodeling and Cardiomyopathy 2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-091 Impairment of Ubiquitin-Proteasome System Caused by a Missense MYBPC3 Mutation and Associated with Cardiac Dysfunction in Hypertrophic Cardiomyopathy(FRS19,Genetic Abnormalities in Cardiac Hypertrophy and Cardiomyopathy (M),Featured Research Sessi
- PJ-231 Can We Reduce β-Blockers to Half Doses in Patients With Stable Heart Failure during Long-term Administration of β-Blockers?(Heart Failure, Clinical 3 (M) : PJ39)(Poster Session (Japanese))
- Beta-Blocker Therapy in Patients with Dilated Cardiomyopathy : Different Effects on Heart Rate and the Role of the Selectivity of Beta-Blockers
- Heart Failure Elevates Serum Levels of Cibenzoline in Arrhythmic Patients(CLINICAL INVESTIGATION)
- Dyssynchrony Imaging, A New Method to Assess Left Ventricular Dyssynchrony Based on Myocardial Strain : Comparison With Traditional Tissue Velocity Method(Echo/Doppler 13 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- 4 Current Status and Surrounding Issues of Clinical Trials in Japan : Lesson and Proposal from our Experience of the Clinical Trials(Clinical Trials Update in Japan and Future Perspective, The 71st Annual Scientific Meeting of the Japanese Circulation Soc
- PJ-047 The Combined Therapy of Angiotensin Converting Enzyme Inhibitor, Angiotensin II Receptor Blocker and Beta-blockers Submaximally Limits Infarct Size(Acute Myocardial Infarction, Basic 2 (IHD) : PJ8)(Poster Session (Japanese))
- PJ-046 Celiprolol, a Selective β_1-Adrenoceptor Antagonist, Limits Infarct Size via NO-dependent Mechanisms(Acute Myocardial Infarction, Basic 2 (IHD) : PJ8)(Poster Session (Japanese))
- Role of Transthoracic Doppler-Determined Coronary Flow Reserve in Patients With Chest Pain
- 5 Identification of the new therapeutic target of heart failure from microarray-based screening of human failing myocardium(Plenary Session 7 (PL-7) (M) Genomic Approaches to Cardiovascular Diseases : Present and Future,Special Program,The 72nd Annual Sci
- 6 Experience of Large-Scale Trial Using ANP or Nicorandil as an Adjunct to Percutaneous Coronary Intervention for Acute Myocardial Infarction(New Horizon in Coronary Interventions for Acute Coronary Syndrome, The 71st Annual Scientific Meeting of the Japa
- The ATP-sensitive Potassium Channel Opener, Nicorandil, Reduces No-reflow Phenomenon and Infarct Size in the Canine Heart
- Adenosine-Induced Cardiac Gene Expression of Ischemic Murine Hearts Revealed by cDNA Array Hybridization
- PJ-027 What Does Electrocardiographic Strain Pattern Mean in Aortic Stenosis? : Assessment With Myocardial Tissue Strain Imaging(Echo/Doppler 3 (I) : PJ5)(Poster Session (Japanese))
- Nano-size liposome coated with polyethylene glycol can deliver drugs to ischemia/reperfused myocardium(Additional Remarks, Plenary Session 2 (PL-2) (IHD) Myocardial Protection Strategy after Reperfusion Therapy in Acute Coronary Syndrome,Special Program,T
- Heterogeneous contraction of the left ventricle demonstrated by 2-dimensional strain imaging
- PJ-032 Clinical Significance and Limitation of Myocardial Washout Rate of Tc-99m-sestamibi in Left Ventricular Remodeling in Patients With Chronic Heart Failure(Nuclear Cardiology 2 (I) : PJ6)(Poster Session (Japanese))
- Patients With Dilated Cardiomyopathy With Attenuated Elevation of Cardiac Sympathetic Activity are Poor Responder to Carvedilol Therapy
- Prognostic Significance of Cardiac Metaiodobenzylguanidine Uptake and Plasma BNP Concentrations before The Carvedilol Therapy in Patients with Chronic Heart Failure
- Angiotensin Converting Enzyme Inhibitor Reduces Cardiac Hypertrophy and Fibrosis in Cardiomyopathic Hamsters via NO-dependent Mechanisms(Heart Failure, Basic 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Left Ventricular Diastolic Flow Propagates Into the Ventricle Not Linearly But Curvilinearly : Temporal Analysis of Propagation Velocity by Trajectory Imaging
- PJ-092 Activation of Adenosine A1 Receptors Inhibits Aldosterone Synthesis in Adrenal Glands(Metabolism/Biochemistry/Energetics-3 (M) PJ16,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Angiotensin II Type 1 Receptor Blocker Prevents Atrial Structural Remodeling in Rats with Hypertension Induced by Chronic Nitric Oxide Inhibition
- 2 How to Find Novel Pathophysiology and Therapy of Chronic Heart Failure from Genomic Database(Perspectives of Genome-wide Study to Identify Genes Underlying Cardiovascular Diseases,Roundtable Discussion 10 (RT10) (M),The 70th Anniversary Annual Scientifi
- PE-256 Feasibility of Transthoracic Doppler-determined Coronary Flow Reserve for the Assessment of Left Main Trunk Stenosis(Echo/Doppler-10 (I) PE43,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Societ
- Genetic Influences in Mouse Spermatogonial Stem Cell Self-Renewal
- OJ-442 Gq-stimulation along with low activity of proteasome induces cardiac apoptosis : Potential mechanism of transition from hypertrophy to failure(Heart Failure, Basic 3 (M) : OJ54)(Oral Presentation (Japanese))
- OJ-324 Antagonism of Aldosterone Receptor Attenuates Severity of Cardiac Dysfunction and Inflammation Induced by Chronic Blockade of NO Synthesis in Rats(Cardiovascular Pharmacology, Basic/Clinical 2 (H) : OJ39)(Oral Presentation (Japanese))
- Canine DNA Array as a Potential Tool for Combining Physiology and Molecular Biology : An Application for the Gene Expression Profile of Regional Ischemic Myocardium
- An Adenosine Analogue, Chloroadenosine, Attenautes Pressure-Overload Myocardial Hypertrophy in Mice
- The New Metalloproteinase Inhibitor Blocks Cardiac Hypertrophy Induced by both Phenylephrine and Angiotensin II
- OJ-020 Oxidative Stress-induced Decline of Proteasome Activity Promotes Accumulation of Proapoptotic Proteins and Contributes to Cardiomyocytes Apoptosis in Failing Heart(Heart failure, basic-2 (M) OJ4,Oral Presentation (Japanese),The 70th Anniversary Ann
- The Pathophysiological Role of Endoplasmic Reticulum Stress in the Failing Hearts : Possibility of Brain-Type Natriuretic Peptide as its Marker (Heart Failure, Basic 6 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Selective Blockade of Serotonin 5HT2A Receptor Increases Coronary Blood Flow via NO-Dependent Pathway Through 5HT1B Receptor in Hypoperfused Canine Hearts(Coronary Circulation, Basic/Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Cir
- Decreased Proteasome Activity by Oxidative Stress Induces Cardiac Myocytes Apoptosis via p53-mediated Pathway(Heart Failure, Basic 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Phosphorylation of Myosin Regulatory Light Chain by Myosin Light Chain Kinase, and Muscle Contraction
- Human Amniotic Epithelial Cells Possess Hepatocyte-like Characteristics and Functions
- Data Mining of the Best Treatments of Chronic Heart Failure and Proposal of Adenosine Therapy as a New Treatment
- DNA array for the discovery of genes related to cardiovascular disease and SNP for its application to the large-scale clinical trials
- PE-541 Glycosaminoglycan Modification of Neuropilin-1 Modulates VEGFR2 Signaling(Molecular biology, vascular-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-126 The Direct Physiological Impact of C-reactive Protein on Ischemicin Vivo Hearts : Reduced Cardiac Nitric Oxide Production but Saved Metabolization(Coronary Circulation, Basic/Clinical 2 (IHD) : OE15)(Oral Presentation (English))
- Differential Effect on Acute Cardioprotection against Myocardial Infarction by Statins : Role of ECTO-5'-Nucleotidase
- A Selective Estrogen Receptor Modulator, Raloxifene, Inhibits the Cardiac Hypertrophy and Dysfunction due to Aortic Banding in Mice
- Preischemic Protein Kinase-A Activation Triggers Cardioprotection of Ischemic Preconditioning via the Inhibition of Rho-Kinase
- FRS-184 Investigation of Gene Regulatory Mechanisms Governing Myocardial Energy Metabolism and the Effects of β-Blocker Therapy in Patients with Heart Failure(Heart Failure : Basic and Clinical Viewpoint (M) : FRS22)(Featured Research Session (English))
- Changes in myocardial gene expression associated with betablocker therapy in patients with chronic heart failure
- Altered gene expression of calcium regulatory protein in patients with chronic heart failure
- PE-118 Discrepancy between Electrocardiographic Type of Intraventricular Conduction Disturbances and Area of Mechanical Dyssynchrony : Assessment with Tissue Synchronization Imaging(Echo/Doppler 4 (I) : PE20)(Poster Session (English))
- OJ-086 Prediction of Exercise Capacity in Patients with Dilated Cardiomyopathy by a Combination of Pulsed and Strain Doppler Echocardiography(Echo/Doppler 1 (I) : OJ11)(Oral Presentation (Japanese))
- Visualization of Ventricular Contraction Sequence by Tissue Tracking Technique : A New Echocardiographic Technique for Evaluating Myocardial Tissue Displacement
- PE-115 Reduced Coronary Flow Velocity Reserve of Left Anterior Descending Artery Under Right Coronary Artery Lesion : Impact of Coronary Steal Phenomenon(Echo/Doppler 4 (I) : PE20)(Poster Session (English))
- HB-EGF Is an Essential Growth Factor for Cardiomyocyte Metabolism : The Possibility for a Novel Therapeutic Target for Heart Failure
- Rho-kinase Inhibitiors Administered After the Onset of Reperfusion Limit Infarct Size : A Novel Strategy for Adjunctive Therapies Against Myocardial Infarction
- A Role of Transient Preischemic Activation of Protein Kinase-A in Ischemic Preconditioning in Vivo : Involvement of p38 Mitogen-activated Protein Kinase
- PE-340 International Comparison of Clinical Use of Inotrope and Vasodilator Therapy for Acute Decompensated Heart Failure(Heart failure, clinical(10)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Preischemic Protein Kinase-A Activation Evokes Ischemic Preconditioning through Rho-Kinase Inhibition Independent of Protein Kinase-C : A Novel Mechanism
- Amlodipine Increases Coronary Blood Flow and Reduces the Severity of Myocardial Ischemia in Canine Hearts : The Role of NO and Adenosine
- Inhibitory Effects of the CP Compound on Coronary Thromboemboli Caused by an Inhibition of Adenosine Receptors during Coronary Hypoperfusion
- PE-193 The Effect of Noninvasive Positive Pressure Ventilation on Treatment of Patients with Flash Pulmonary Edema Admitted to the Emergency Department(Heart failure, clinical(08)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japane
- The Long-acting Calcium Channel Blockers Attenuate Cardiac Hypertrophy Induced by Chronic NO Inhibition : The Investigation of the Potential Subcellular Mechanisms
- Gene Expression Profile of Failing Human Hearts In Patients with Dilated Cardiomyopathy Using "Gene Chip" Analysis
- Cellular Mechanisms of Cardioprotection Afforded by Inhibitors of Angiotensin Converting Enzyme in Ischemic Hearts: Role of Bradykinin and Nitric Oxide
- Improvement by 5-Amino-4-Imidazole Carboxamide Riboside of the Contractile Dysfunction That Follows Brief Periods of Ischemia Through Increases in Ecto-5′-Nucleotidase Activity and Adenosine Release in Canine Hearts
- Lesion Severity and Hypercholesterolemia Determine Long-Term Prognosis of Vasospastic Angina Treated With Calcium Channel Antagonists
- Cardiac Hypertrophy is Inhibited by Antagonism of Metalloproteinase Processing of HB-EGF
- Are the Histological Improvements Operated by Beta-Blocker Therapy in Patients with Dilated Cardiomyopathy?
- Impact of reduced left atrial functions on diagnosis of paroxysmal atrial fibrillation : Results from analysis of time-left atrial volume curve determined by two-dimensional speckle tracking