An Association between Metabolic Syndrome and the Estimated Glomerular Filtration Rate
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概要
- 論文の詳細を見る
Objective Metabolic syndrome (MetS) is a major public health problem. However, few studies have examined the significance of MetS as a risk factor for the development of chronic kidney disease (CKD) in the general Japanese population. Methods Study participants without a clinical history of stroke, transient ischemic attack, myocardial infarction, angina, or renal failure (1,158 men, aged 61±15 years and 1,606 women, aged 63±12 years) were recruited from a single community. We examined the cross-sectional relationship between MetS and renal function as evaluated by estimated glomerular filtration rate (eGFR). Results The presence of MetS was consistently associated with reduced eGFR, with the level of reduction proportional to the number of MetS components present. Multiple linear regression analysis using eGFR as an objective variable showed that BMI, DBP, antihypertensive drug use, high-density lipoprotein cholesterol, antilipidemic drug use and fasting blood glucose, which were components of MetS, were significantly and independently associated with eGFR, in addition to age and low-density lipoprotein cholesterol. Individuals with MetS showed a multivariate-adjusted odds ratio of 1.53 (95% confidence interval, 1.10-2.13) for CKD compared to those without MetS. Conclusions MetS was significantly associated with decreased eGFR in the general population.
- 社団法人 日本内科学会の論文
著者
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TABARA Yasuharu
Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine
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Kohara Katsuhiko
Department Of Cardiovascular Medicine Nephrology And Neurology Faculty Of Medicine And Dialysis Unit
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MIKI Tetsuro
Department of Geriatric Medicine, Ehime University Graduate School of Medicine
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Tabara Yasuharu
国立循環器病センター研究所 疫学部
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Kawamoto Ryuichi
Department of Internal Medicine, Nomura Municipal Hospital
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Tabara Yasuharu
Department of Geriatric Medicine, Ehime University School of Medicine
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