Are the Associations between Life-style Related Factors and Plasma Total Homocysteine Concentration Different According to Polymorphism of 5, 10-Methylenetetrahydrofolate Reductase Gene (C677T MTHFR)? : A Cross-sectional Study in a Japanese Rural Populati
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概要
- 論文の詳細を見る
Mild hyperhomocysteinemia is one of the known strong risk factors for atherosclerotic diseases, and therefore it is important to clarify factors that could determine plasma total homocysteine(tHcy)level.A cross-sectional study with a random sample of 455 Japanese rural residents aged 40-69 years was conducted in 2000 to investigate the associations of plasma tHcy concentration with 5, 10-methylenetetrahydrofolate reductase(MTHFR)gene and selected life-style related factors.The frequency of the mutant allele, Valine(V)allele, was 0.40 and the prevalence of W genotype was 14.3 %.Plasma tHcy concentration in W was significantly higher than those in two other genotypes.There were significant inverse associations of plasma tHcy with serum folate and serum vitamin B12(P<0.001 for trend, respectively);both being stronger in W than in other genotypes.The number of cigarettes smoked per day was positively associated with plasma tHcy concentration.A multivariate regression analysis revealed that serum folate, serum vitamin B12, and MTHFR genotype were independently associated with plasma tHcy.The inter-individual variance of plasma tHcy was more explained by serum folate and vitamin B12 than by MTHFR genotype.Higher intakes of folate, vitamin B12, and non-smoking may be important to prevent mild hyperhomocysteinemia and the eventual atherosclerotic diseases in this Japanese rural population.J Epidemiol, 2002;12:126-135
- 日本疫学会の論文
著者
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KOKUBO Yoshihiro
Department of Preventive Cardiology, National Cardiovascular Center
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DATE Chigusa
Department of Nutrition and Food Science, Faculty of Human Environmental Science, Mukogawa Women's U
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Date Chigusa
Osaka City University Medical School
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Lwin Htay
国立健康・栄養研究所 健康・栄養調査研究部
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Lwin Htay
Department Of Epidemiology Medical Research Institute Tokyo Medical And Dental University
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Lwin Htay
Division Of Health And Nutrition Monitoring National Institute Of Health And Nutrition
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YOKOYAMA Tetsuji
Department of Technology Assessment and Biostatistics, National Institute of Public Health
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TANAKA Heizo
National Institute of Health and Nutrition
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Yoshiike N
National Institute Of Health And Nutrition
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Tanaka H
Tanaka Hospital
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TAGUCHI Hirokuni
Kochi Medical School
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YOSHIIKE Nobuo
Division of Adult Health Science, The National Institute of Health and Nutrition
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Date C
Osaka City Univ. School Of Medicine
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Tanaka H
National Institute Of Health And Nutrition
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Kokubo Yoshihiro
Department Of Cardiology National Cardiovascular Center
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Hayakawa T
Department Of Internal Medicine Ii Nagoya University School Of Medicine
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Yokoyama T
Department Of Technology Assessment And Biostatistics National Institute Of Public Health
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Yokoyama Tetsuji
Department Of Epidemiology Medical Research Institute Tokyo Medical And Dental University
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Date C
Faculty Of Human Life And Environment Nara Women's University
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Date Chigusa
Osaka City University Faculty Of Medicine
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Date Chigusa
Department Of Food Science And Nutrition Faculty Of Human Life And Environment Nara Women's Uni
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Date Chigusa
Faculty Of Human Life And Environment Nara Women's University
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Hayakawa Tetsuo
Intractable Pancreatic Disease Investigation And Research Group Of The Japanese Ministry Of Health A
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Yokoyama Tetsuji
Medical Research Institute Tokyo Medical And Dental University
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YOSHIIKE Nobuo
Division of Adult Health Science The National Institute of Health and Nutrition, Tokyo
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