Polymorphism of Methylenetetrahydrofolate Reductase Gene (C677T MTHFR) is Not a Confounding Factor of the Relationship Between Serum Uric Acid Level and the Prevalence of Hypertension in Japanese Men
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概要
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Background The association between serum uric acid (UA) and the prevalence of hypertension, and the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphism and hypertension remains unclear. The aim of the present study was to investigate whether the C677T MTHFR mutation genotype (VV) is independently associated with the prevalence of hypertension or blood pressure (BP), and examined any interaction of MTHFR and UA with BP. Methods and Results Participants were randomly selected from all residents (aged 40-69 years) in a rural county of Japan, and the data for the men (n=335) were analyzed. 'Hypertension' was defined as systolic BP ≥140 and/or diastolic BP ≥90 mmHg and/or being administered antihypertensive medication. Serum UA level was independently associated with the prevalence of hypertension (odds ratio (95% confidence interval)=2.7 (1.2-5.9), p=0.047) for the highest tertile of serum UA (≥398.5μmol/L (6.7 mg/dl)) vs that of the lowest tertile (<321.2μmol/L (5.4 mg/dl)), but the MTHFR mutation was not independently associated with prevalence of hypertension or BP. No interaction of the MTHFR mutation and serum UA with BP was found. Conclusions The mutation of C677T MTHFR was not independently associated with the prevalence of hypertension or BP levels although serum UA was. Furthermore, the relationship between serum UA and BP was not modulated by the MTHFR mutation in Japanese men.
- 社団法人日本循環器学会の論文
- 2005-12-20
著者
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Date Chigusa
Osaka City University Medical School
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Lwin Htay
国立健康・栄養研究所 健康・栄養調査研究部
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Lwin Htay
Department Of Epidemiology Medical Research Institute Tokyo Medical And Dental University
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Lwin Htay
Division Of Health And Nutrition Monitoring National Institute Of Health And Nutrition
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YOKOYAMA Tetsuji
Department of Technology Assessment and Biostatistics, National Institute of Public Health
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TANAKA Heizo
National Institute of Health and Nutrition
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Yoshiike N
National Institute Of Health And Nutrition
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Tanaka H
Tanaka Hospital
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TAGUCHI Hirokuni
Kochi Medical School
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YOSHIIKE Nobuo
Division of Adult Health Science, The National Institute of Health and Nutrition
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Date C
Osaka City Univ. School Of Medicine
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Tanaka H
National Institute Of Health And Nutrition
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SAITO Kyoko
Department of Anatomy and Embryology, Ehime University School of Medicine
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Yamamoto Akio
Hyogo Prefectural Institute of Public Health and Environmental Science
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Date Chigusa
Faculty of Human Life and Environment, Nara Women's University
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Hayakawa T
Department Of Internal Medicine Ii Nagoya University School Of Medicine
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Yokoyama T
Department Of Technology Assessment And Biostatistics National Institute Of Public Health
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Yokoyama Tetsuji
Department Of Epidemiology Medical Research Institute Tokyo Medical And Dental University
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SAITO Kyoko
National Institute of Health and Nutrition
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Date C
Faculty Of Human Life And Environment Nara Women's University
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Date Chigusa
Osaka City University Faculty Of Medicine
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Date Chigusa
Faculty Of Human Life And Environment Nara Women's University
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Saito Kyoko
Department Of Anatomy And Embryology Ehime University School Of Medicine
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Hayakawa Tetsuo
Intractable Pancreatic Disease Investigation And Research Group Of The Japanese Ministry Of Health A
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Yokoyama Tetsuji
Medical Research Institute Tokyo Medical And Dental University
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YOSHIIKE Nobuo
Division of Adult Health Science The National Institute of Health and Nutrition, Tokyo
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