Apolipoprotein E Genetic Polymorphism and Stroke Subtypes in a Bangladeshi Hospital-Based Study

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概要

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• The association between apolipoprotein E (apoE) genetic polymorphism and stroke has not been concordant in different racial populations. We investigated the association between apoE genotypes and stroke subtypes by a case-control study in Bangladesh for the first time among south Asian countries.First-ever-stroke patients (n=227; cerebral infarction, n=147, cerebral hemorrhage, n=80) and 190 controls were recruited from a hospital in Dhaka, Bangladesh. The diagnosis of stroke was based on CT and clinical findings. Cerebral infarction was classified anatomically into cortical and penetrating region. Infarction in the cortical region was further categorized etiologically into thrombosis and embolism. Cerebral hemorrhage was considered as a whole in all analyses. ApoE genotypes were determined by restriction fragment length polymorphism. In the multivariate conditional logistic regression analysis adjusted for potential confounders both the ε 3/ε 4 genotype and ε4 carrier conferred an approximately 3-fold increased risk for cerebral thrombosis in the cortical artery region (OR 3.5, 95% CI 1.2 to 10.4 and OR 3.1, 95% CI 1.1 to 9.0, respectively) compared with ε 3/ε 3 genotype. However, when the analysis was restricted to the elderly (>60 years), ε 2 carrier was associated with a risk of hemorrhagic stroke (OR 19.2, 95% CI 1.3 to 295.2). Our study suggested that both apoEε 3/ε 4 genotype andε 4 carriers were risk factors for cerebral thrombosis in cortical artery region, whereas ε 2 carrier was a risk factor for hemorrhagic stroke in the elderly. J Epidemiol, 2001 ; 11 : 131-138

• 日本疫学会の論文

著者

• Kokubo Y

  Department Of Preventive Cardiology National Cardiovascular Center

• YOKOYAMA Tetsuji

  Department of Technology Assessment and Biostatistics, National Institute of Public Health

• Zaman M.

  Rheumatic Fever And Heart Diseases Control Center

• CHOWDHURY Anisul

  Medical Research Institute, Tokyo Medical and Dental University

• YOKOYAMA Tetsuji

  Medical Research Institute, Tokyo Medical and Dental University

• KOKUBO Yoshihiro

  Medical Research Institute, Tokyo Medical and Dental University

• ZAMAN Mohammad

  Rheumatic Fever and Heart Diseases Control Center

• HAQUE Anisul

  Department of Neurology, Bangabandhu Sheikh Mujib Medical University

• TANAKA Heizo

  Medical Research Institute, Tokyo Medical and Dental University

• Chowdhury Anisul

  Medical Research Institute Tokyo Medical And Dental University

• Tanaka H

  National Institute Of Health And Nutrition

• Hayakawa T

  Department Of Internal Medicine Ii Nagoya University School Of Medicine

• Yokoyama T

  Department Of Technology Assessment And Biostatistics National Institute Of Public Health

• ZAMAN Mohammad

  Department of Epidemiology, Medical Research Institute, Tokyo Medical and Dental University

• Tanaka Heizo

  Medical Research Institute Tokyo Medical And Dental University

• Yokoyama Tetsuji

  Medical Research Institute Tokyo Medical And Dental University

• Haque Anisul

  Department of Electrical and Electronic Engineering, East West University, 43 Mohakhali C/A, Dhaka 1212, Bangladesh

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