Gly 395 Arg Polymorphism of PPARα Gene Was Not Detected in Japanese Population of 729 Individuals
スポンサーリンク
概要
- 論文の詳細を見る
Peroxisome proliferator-activated receptor α (PPARα) is a member of the nuclear receptor superfamily and participates in the regulation of key proteins involved in lipid metabolism, fatty acid oxidation, homeostasis, and inflammation. Several polymorphisms of the human PPARα gene, such as Leu 162 Val polymorphism and Val 227 Ala polymorphism, have been described in different races. Recently, another PPARα polymorphism Gly 395 Arg polymorphism has been reported in Caucasian and African subjects. Using the Invader assay, we searched for this polymorphism in 729 Japanese adults randomly selected in a rural population. Although the synthesized oligonucleotides of each polymorphism could be distinguished clearly, all 729 individuals had the Gly (G) allele and none had the Arg (C) allele. These data suggest that there is racial variability in the frequencies of PPARα gene polymorphisms.
- 日本ビタミン学会の論文
著者
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YOSHIIKE Nobuo
National Institute of Health and Nutrition
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YOKOYAMA Tetsuji
Department of Technology Assessment and Biostatistics, National Institute of Public Health
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TANAKA Heizo
National Institute of Health and Nutrition
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Yoshiike N
National Institute Of Health And Nutrition
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YOKOYAMA Tetsuji
National Institute of Public Health
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Tanaka H
Tanaka Hospital
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TAGUCHI Hirokuni
Kochi Medical School
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Tanaka H
National Institute Of Health And Nutrition
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Kamei Yasutomi
National Institute Of Health And Nutrition:tokyo Medical And Dental University
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Hayakawa T
Department Of Internal Medicine Ii Nagoya University School Of Medicine
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Yokoyama T
Department Of Technology Assessment And Biostatistics National Institute Of Public Health
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SAITO Kyoko
National Institute of Health and Nutrition
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EZAKI Osamu
National Institute of Health and Nutrition
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Yokoyama Tetsuji
Medical Research Institute Tokyo Medical And Dental University
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Kamei Yasutomi
National Institute of Health and Nutrition:PRESTO, Japan Science and Technology Agency:Tokyo Medical and Dental University
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