Association of Human Cholesteryl Ester Transfer Protein-Taql Polymorphisms with Serum HDL Cholesterol Levels in a Normolipemic Japanese Rural Population

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We examined allele frequencies for the common cholesteryl ester transfer protein(CETP)TaqI polymorphisms and the associations of CETP-Taql polymorphisms with serum lipid and lipoprotein levels taking into account for selected lifestyle factors in a well-characterized random sample of 527 healthy subjects living a rural community in Japan(256 men and 271 women aged 40-69 years).B2 allele frequency was 0.39 in men and 0.41 in women, and its presence was significantly associated with increased levels of HDL cholesterol(HDL-C)in men(P=0.003 for linear trend).A similar tendency in women was observed, although P value for trend did not reach 0.05.There were not significant interactions between TaqlB genotype and smoking and alcohol drinking or daily physical activity in HDL-C.There were no statistically significant differences among TaqlA genotype in lipid and lipoprotein levels.Multiple linear regression analysis showed that B1 B2 and B2b2 explained 1.7% and 2.2%, and 0.6% and 1.0% of variation in men and in women in HDL-C, respectively.We conclude that the CETP-TaglB polymorphism has a quantitative influence, but appears to be stronger one in men, on HDL-C levels even after adjustment for important lifestyle factors(smoking, alcohol drinking, and daily physical activity). J Epidemiol, 2002;12:77-84
日本疫学会の論文