Systemic Vasculitis Associated with α1-antitrypsin Deficiency
スポンサーリンク
概要
- 論文の詳細を見る
We describe a rare case of systemic vasculitis associated with α1-antitrypsin (α1-AT) deficiency. Mutational analysis of the α1-AT gene in this patient revealed a homozygous α1-AT Mnichinan variant. α1-AT possesses broad-spectrum inhibitory activity against many serine proteases, including human neutrophil elastase, to help maintaining the crucial balance between proteases and protease inhibitors. The increase in free protease activity in the context of α1-AT deficiency may induce exacerbation of the vasculitis. This serious genetic defect severely affects the balance between a protease and a protease inhibitor at the pathological site.(Internal Medicine 42: 619-623, 2003)
- 社団法人 日本内科学会の論文
- 2003-07-01
著者
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SHIMODA Kazuya
Department of Internal Medicine, Gastroenterology and Hematology, Faculty of Medicine, Miyazaki Univ
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OKAMURA Takashi
Division of Hematology, Department of Medicine, Kurume University School of Medicine
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Okamura T
Division Of Hematology Department Of Medicine Kurume University School Of Medicine
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TSUKAMOTO Hiroshi
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu Universi
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HORIUCHI Takahiko
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu Universi
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OTSUKA Takeshi
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu Universi
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HATTORI Sachiko
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital
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KINOSHITA Sachiko
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital
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HAMASAKI Naotaka
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital
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Tsuda Hiroyuki
Division Of Clinical Hematology Kumamoto City Hospital
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Furugo Isao
Department Of Internal Medicine Kitakyushu Municipal Medical Center
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Harada Mine
Department Of Medicine And Biosystemic Science Kyushu University Graduate School Of Medical Sciences
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Harada Mine
岡山大学 第2内科
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Inoue Hisako
Department Of Internal Medicine Faculty Of Medicine Saga University
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Karashima Eiji
Department Of Medicine And Systemic Science Kyushu University
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Karashima Eiji
Department Of Medicine And Biosystemic Science Graduate School Of Medical Science Kyushu University
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Karashima Eiji
Department Of Cardiology National Fukuoka Higashi Medical Center
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Shimoda K
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
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Shimoda Kazuya
九州大学 医学部病態情報学
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Takii Yasushi
Department Of Medicine And Biosystemic Science Graduate School Of Medical Science Kyushu University
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Yamanaka Motoko
Department Of Clinical Chemistry And Laboratory Medicine Kyushu University Hospital
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Nakashima Hitoshi
Division Of Nephrology And Rheumatology Department Of Internal Medicine Fukuoka University School Of
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Nakashima Hitoshi
Department Of Cardiology National Hosptal Organization Kagoshima Medical Center
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Horiuchi Takahiko
札幌医科大学 医学部
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Horiuchi Takahiko
Kyushu University Graduate School Of Medical Sciences
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Akahoshi Mitsuteru
九州大学 医学研究院病態修復内科学
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Akahoshi Mitsuteru
Department Of Medicine And Biosystemic Science Graduate School Of Medical Science Kyushu University
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Akahoshi Mitsuteru
First Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Shimoda Kazuya
九州大学 第1内科
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Tanaka H
Tanaka Hospital
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Tanaka Hisato
札幌医科大学 医学部
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TAGUCHI Hirokuni
Kochi Medical School
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Hamaguchi Motohiro
Department Of Hematology Clinical And Research Center National Hospital Organization Nagoya Medical
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Shinagawa K
Okayama Univ. Hospital Okayama Jpn
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Shinagawa Katsuji
岡山大学 第2内科
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Harada Mine
九州大学 医学研究院病態修復内科学
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Okamura Takashi
Division Of Hematology Department Of Medicine Kurume University School Of Medicine
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Tanaka Heizo
Tanaka Hospital
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Tsukamoto H
Division Of Clinical Hematology Kumamoto City Hospital
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Shimoda Kazuya
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
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Harada Mine
Department Of Cardiovascular Physiology Ii Okayama University Graduate School Of Medicine And Dentis
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Nakashima Hitoshi
Division Of Nephrology And Rheumatology Department Of Internal Medicine Faculty Of Medicine Fukuoka
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Nakashima Hitoshi
Department Of Cardiology National Hospital Kyushu Cardiovascular Center
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Nakashima Hitoshi
Department Of Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University
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Harada Mine
Department Of Internal Medicine Ii Okayama University Graduate School Of Medicine And Dentistry
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Harada M
Chiba Univ. Chiba Jpn
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Hidaka Michihiro
Department Of Internal Medicine Kumamoto Medical Center National Hospital Organization
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Sunami Kazutaka
Division Of Hematology Department Of Internal Medicine National Hospital Organization Okayama Medica
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Otsuka T
Munakata Medical Association Hospital
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Shinagawa Katsushi
The Second Department Of Internal Medicine
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Shinagawa Katsuji
Division Of Hematology/oncology Okayama University Medical School
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Tanaka Heizo
Division Of Health And Nutrition Monitoring National Institute Of Health And Nutrition
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Hattori Sachiko
Department Of Clinical Chemistry And Laboratory Medicine Kyushu University Hospital
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Tsukamoto Hiroshi
Division Of Clinical Hematology Kumamoto City Hospital
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Harada N
Department Of Internal Medicine Kumamoto Medical Center National Hospital Organization
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Harada Mine
Second Department Of Internal Medicine Okayama University School Of Medicine
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Otsuka Teruhisa
Medicine And Biosystemic Science Kyushu University Graduate School Of Medical Sciences
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Okamura Takayuki
Osaka Medical Center And Research Institute For Maternal And Child Health
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Okumura Takayuki
Department Of Pediatrics Osaka University School Of Medicine
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Hamasaki Naotaka
Department Of Clinical Chemistry And Laboratory Medicine Kyushu University Hospital
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Hamasaki Naotaka
Department Of Biochemistry Fukuoka University School Of Medicine
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Kinoshita Sachiko
Department Of Clinical Chemistry And Laboratory Medicine Kyushu University Hospital
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Horiuchi Takahiko
Department Of Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University
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Otsuka Takeshi
Department Of Chemistry School Of Science Kitasato University
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Tsukamoto Hiroshi
Department Of Biological Functions And Engineering Kyushu Institute Of Technology
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Hara Masamichi
Department Of Internal Medicine Kumamoto Medical Center National Hospital Organization
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Shimoda Kazuya
Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University
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Okamura Takashi
Second Department Of Medicine Kurume University School Of Medicine
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Sugiyama Kenji
Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers
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Shimoda Kazuya
Department Of Cardiology Jichi Medical School
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Sugiyama Katsuki
Division Of Hematology And Oncology Department Of Internal Medicine The Jikei University School Of M
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Inoue Hisako
Department Of Medicine And Biosystemic Science Graduate School Of Medical Science Kyushu University
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Nakashima Hitoshi
Division Of Nephrology And Rheumatology Department Of Internal Medicine Faculty Of Medicine Fukuoka
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Harada Mine
Department Of Biosystemic Science And Medicine Kyushu University Graduate School Of Medical Sciences
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Hara Masamichi
Ehime Prefectural Central Hospital Matsuyama Jpn
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Hamaguchi M
Division Of Hematology Ehime Prefectural Central Hospital
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