Exercise-Induced Hepatocyte Growth Factor Production in Patients After Acute Myocardial Infarction : Its Relationship to Exercise Capacity and Brain Natriuretic Peptide Levels
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概要
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Background The hepatocyte growth factor (HGF) is a multifunctional cytokine with cardioprotective properties and potent myogenic activity for vascular endothelium. In patients after acute myocardial infarction, exercise training has the beneficial effects on cardiovascular adaptations. We hypothesized that exercise induces HGF production in those patients. If this hypothesis is correct, HGF production may be associated with clinical parameters of cardiovascular function. Methods and Results In 20 patients after acute myocardial infarction, HGF levels in the pulmonary artery (HGF_<PA>) and aorta (HGF_<Ao>) were determined at rest and during supine submaximal exercise, with cardiac output (CO) measured by catheterization. Exercise-induced HGF production was calculated by using the following equation : [(HGF_<PA>-HGF_<Ao>)×CO during exercise]-[(HGF_<PA>-HGF_<Ao>)×CO at rest]. On a separate day, peak oxygen uptake (VO_2) was determined during a symptom-limited upright cardiopulmonary exercise test. Exercise increased HGF production (from 1.6±3.0 to 9.0±6.3μg/ml, p<0.001). Exercise-induced HGF production was inversely related to peak VO_2 (r=-0.664, p<0.01) and positively related to levels of brain natriuretic peptide (BNP), a biochemical marker for post-infarction ventricular remodeling (r=0.686, p<0.01). Conclusions Exercise significantly increases HGF production. This phenomenon may play an important role in post-infarction patients, particularly with reduced exercise tolerance and elevated BNP levels.
- 社団法人日本循環器学会の論文
- 2004-03-20
著者
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GOTO Yoichi
Division of Cardiology, National Cardiovascular Center
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NONOGI Hiroshi
Division of Cardiology, National Cardiovascular Center
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Naritomi Hiroaki
Division Of Cardiology National Cardiovascular Center
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MIYAZAKI Shunichi
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishiroda
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YASUDA Satoshi
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishiroda
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Yuda Satoshi
Tohoku University Graduate School Of Medicine
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Yasuda Satoshi
Division Of Cardiology Department Of Internal Medicine Tohoku University Graduate School Of Medicine
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Nonogi Hiroshi
Division Of Cardiology And Emergency Medicine National Cardiovascular Center
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Yuda Satoshi
Division Of Cardiology Department Of Internal Medicine Tohoku University Graduate School Of Medicine
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Takaki Hiroshi
Division of Cardiology, National Cadiovascular Center
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Asaumi Yasuhide
Division of Cardiology, National Cardiovascular Center
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Takaki Hiroshi
National Cardiovasucular Center
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Baba Takeshi
Division of Cardiology, National Cardiovascular Center
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Baba Takeshi
Division Of Cardiology National Cardiovascular Center
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Miyazaki Shunichi
Division Of Cardiology Department Of Internal Kinki University School Of Medicine
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Goto Yoichi
Division Of Cardiology Department Of Medicine National Cardiovascular Center
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Yasuda Satoshi
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Tsutsui Hiroshi
Division Of Cardiology Department Of Medicine National Cardiovascular Center
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Sutani Yasuo
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Asaumi Yasuhide
Division Of Cardiology Department Of Medicine National Cardiovascular Center
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Asaumi Yasuhide
Divison Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Takaki Hiroshi
Division Of Cardiology National Cardiovascular Center
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Takaki Hiorshi
Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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Yasuno Shinji
National Cardiovascular Center Department Of Internal Medicine
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Tsutsui Hiroshi
Division Of Cardiovascular Medicine National Cardio Vascular Center
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Nonogi Hiroshi
Division Of Cardiac Care Unit Department Of Cardiovascular Medicine National Cerebral And Cardiovasc
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Takaki Hiroshi
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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