Influence of Calcium Antagonists on Long-term Survival of Patients Treated with Coronary Angioplasty
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概要
- 論文の詳細を見る
A meta-analysis reported that nifedipine increased mortality dose-dependently in patients with coronary artery disease. However, there have been few studies (specifically in Asians) on the long-term prognosis of patients treated with calcium antagonists after successful coronary angioplasty (PTCA). The subjects consisted of 583 consecutive patients (461 males, aged 59 ± 10), who underwent successful elective PTCA between 1985 and 1990. First, they were divided into two groups; the calcium antagonist (+) group (n = 560) and the calcium antagonist (-) group (n = 23), and were evaluated in terms of total survival and cardiac events. Second, the calcium antagonist (+) group was further divided into 4 groups according to calcium antagonist type, i.e., short-acting nifedipine group (n = 156), long-acting nifedipine group (n = 203), diltiazem group (n = 184) and the other group (n = 17), and these groups were evaluated in the same way. The primary end-point was set as death from any cause. Secondary end-points were any cardiac events, including non-fatal acute myocardial infarction, coronary artery bypass surgery and repeat PTCA. The mean follow-up period was 4.5 ± 1.8 years. A multivariate analysis was performed with the Cox proportional-hazard model. The Kaplan-Meier analysis showed that the calcium antagonist (-) group had significantly worse prognoses than the calcium antagonist (+) group (p < 0.05), and that there was no significant difference among the prognoses of the four calcium antagonists groups. The multivariate analysis revealed that the use of a calcium antagonist was one of the independent factors positively contributing to the prognosis. The use of any type of calcium antagonist did not increase mortality in patients who underwent successful elective PTCA, rather, it contributed to a favorable outcome.
- Japanese Heart Journal Associationの論文
著者
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GOTO Yoichi
Division of Cardiology, National Cardiovascular Center
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NONOGI Hiroshi
Division of Cardiology, National Cardiovascular Center
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Sumida Hitoshi
Division of Cardiology, Kumamoto Red-Cross Hospital
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Sumida Hitoshi
Division Of Cardiology National Cardiovascular Center
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Sumida Hitoshi
国立循環器病センター
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Nonogi Hiroshi
国立循環器病センター研究所 疫学部
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KANZAKI Hideaki
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishiroda
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MIYAZAKI Shunichi
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishiroda
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NOGUCHI Teruo
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishiroda
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YASUDA Satoshi
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishiroda
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DAIKOKU Satoshi
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishiroda
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MORII Isao
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishiroda
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ITOH Akira
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishiroda
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Morii Isao
Division Of Cardiology Department Of Internal Medicine Hokusetsu General Hospital
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Noguchi Teruo
国立循環器病センター 心臓血管内科
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Kanzaki Hideaki
Division Of Cardiology National Cardiovascular Center
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Kanzaki Hideaki
国立循環器病センター 心臓血管内科
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Daikoku Satoshi
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Noguchi Teruo
Division Of Cardiology Department Of Medicine National Cardiovascular Center
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Itoh Akira
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Miyazaki Shunichi
Division Of Cardiology Department Of Internal Kinki University School Of Medicine
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Goto Yoichi
Division Of Cardiology Department Of Medicine National Cardiovascular Center
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Yasuda Satoshi
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Nonogi Hiroshi
Division Of Cardiac Care Unit Department Of Cardiovascular Medicine National Cerebral And Cardiovasc
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NOGUCHI Teruo
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Osaka, Japan
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SUMIDA Hitoshi
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Osaka, Japan
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MORII Isao
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Osaka, Japan
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MIYAZAKI Shunichi
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Osaka, Japan
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NONOGI Hiroshi
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Osaka, Japan
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DAIKOKU Satoshi
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Osaka, Japan
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KANZAKI Hideaki
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Osaka, Japan
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YASUDA Satoshi
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Osaka, Japan
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