Cardiac Transplantation Under New Legislation for Organ Transplantation in Japan : Report of Two Cases
スポンサーリンク
概要
- 論文の詳細を見る
During the past 2 years since new legislation for organ transplantation from brain-dead donors came into effect in Japan, 3 cardiac transplants have been carried out, 2 of which were performed at the National Cardiovascular Center (NCVC). The recipient cases were 46- and 25-year-old male patients who suffered from end-stage dilated cardiomyopathy and had been listed for cardiac transplantation in the Japan Organ Transplantation Network as status I candidates. The first patient was supported by the use of a paracorporeal air-driven left ventricular assist device of the NCVC type, and had a moderate degree of renal and hepatic dysfucntion at the time of transplantation. Donor hearts were transported from distant hospitals (Tokyo and Miyagi prefecture) and the transportation time was 1h 33min and 2h 4min, respectively. The operation was performed by the standard technique (Lower-Shumway) in the first patient and by the bicaval anastomosis technique in the second patient. Reperfusion of the transplanted heart was performed retrogradely through the coronary sinus utilizing leukocyte-depleted blood with a gradual increase in temperature. Total ischemic time was 3h 34min and 3h 35min, respectively. Weaning from the cardiopulmonary bypass was easy and uneventful in each patient. Immunosuppressive therapy was conducted with OKT-3 induction in the first patient because of the coexisting renal dysfunction and with a triple immunosuppressive regimen for both patients. Routine endomyocardial biopsy showed acute rejection of less than grade Ib, and the patients were discharged on the 65th and 46th postoperative day, respectively. At present, both patients are in the NYHA class I state and are ready to return to work. The uneventful recovery seen in these patients shows the advances made in transplant medicine, including the progress and imoprovement of immunosuppressive therapy, surgical techniques, myocardial protection, and detection and treatment of infection. Further efforts are required to fully establish the cardiac transplantation program in Japan.
- 社団法人日本循環器学会の論文
- 2000-04-20
著者
-
KOMAMURA Kazuo
Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center
-
KITAMURA Soichiro
Department of Cardiovascular Surgery, National Cardiovascular Center
-
NAKATANI Takeshi
Department of Organ Transplantation, National Cardiovascular Center
-
Nonogi Hiroshi
国立循環器病センター研究所 疫学部
-
Nakagami Hironori
Division Of Gene Therapy Science Osaka University Graduate School Of Medicine
-
Nonogi Hiroshi
Department Of Cardiovascular Medicine National Cardiovascular Center
-
Nonogi Hiroshi
Department Of Cardiology National Cardiovascular Center
-
Minatoya Kenji
Department of Cardiovascular surgery, National cardiovascular center
-
Miyatake Kunio
Department of Cardiovascular Medicine, National cardiovascular center
-
Kobayashi Junjiro
Department of Cardiac Surgery, National Cardiovascular Center
-
Yagihara Toshikatsu
Department of Cardiology, National Cardiovascular Center
-
Sasako Yoshikado
Department Of Cardiovascular Surgery Osaka University
-
Yutani Chikao
Department Of Pathology National Cardiovascular Center
-
Yutani Chikao
Department Of Life Science Okayama University Of Science
-
Hanatani Akihisa
Department of Organ Transplantation
-
Miyatake Kunio
Department Of Internal Medicine National Cardiovascular Center
-
MINATOYA Kenji
National Cardiovascular Center
-
Nonogi Hiroshi
The Third Division Department Of Internal Medicine Kyoto University Hospital
-
由谷 親夫
Department Of Pathology National Cardiovascular Center
-
Yagihara Toshikatsu
Department Of Organ Transplantation Cardiovascular Surgery National Cardiovascular Center
-
Sasako Yoshikado
Department Of Cardiovascular Surgery Osaka University Graduate School Of Medicine
-
Imakita Masami
Rinku General Medical Center
-
Band Ko
Department of Cardiovascular Surgery, Medicine, Radiology, and Pathology, National Cardiovascular Ce
-
Imakita Masami
Department of Cardiovascular Surgery, Medicine, Radiology, and Pathology, National Cardiovascular Ce
-
Kuro Masakazu
Department of Cardiovascular Surgery, Medicine, Radiology, and Pathology, National Cardiovascular Ce
-
Kimura Koji
Department of Cardiovascular Surgery, Medicine, Radiology, and Pathology, National Cardiovascular Ce
-
Kimura Kohji
Departments Of Radiology National Cardiovascular Center
-
Hanatani Akihisa
Departments Of Pharmacy National Cardiovascular Center
-
Hanatani Akihisa
Organ Transplantation National Cardiovascular Center
-
Komamura Kazuo
Department Of Cardiology National Cardiovascular Center
-
Band Ko
Cardiovascular Surgery National Cardiovascular Center
-
Bandoh Ko
Department Of Cardiovascular Surgery National Cardiovascular Center
-
Yagihara Toshikatsu
Department Of Cardiovascular Surgery National Cardiovascular Center
-
Imakita Masami
Department Of Cardiovascular Dynamics National Cardiovascular Center
-
Sasako Yoshikado
The Department Of Cardiovascular Surgery National Cardiovascular Center
-
Suematsu Yoshihiro
Department of Cardiothoracic Surgery
-
木村 晃二
国立循環器病センター 心臓血管
-
Kuro Masakazu
Department Of Anesthesiology National Cardiovascular Center
-
Kuro Masakazu
Department Of Cardiovascular Surgery Medicine Radiology And Pathology National Cardiovascular Center
-
Kobayashi Junjiro
Department Of Applied Physics School Of Science And Engineering Waseda University
-
Miyatake Kunio
Department Of Cardiology National Cardiovascular Center
-
Sasako Yoshikado
Department Of Cardiothoracic Surgery
-
Sasako Yoshikado
The Departments Of Cardiovascular Surgery
-
Nakatani Takeshi
Department Of Cardiology Pathology Organ Transplantation And Nuclear Medicine National Cardiovascula
-
Kitamura Soichiro
Department Of Cardiology National Cardiovascular Center
-
Kusumoto Miyako
Cardiac Division National Cardiovascular Center
-
Nakatani Takeshi
Organ Transplantation National Cardiovascular Center
-
Minatoya Kenji
Department Of Cardiology National Cardiovascular Center
-
Imakita Masami
The Department Of Pathology National Cardiovascular Center
-
Hanatani Akihisa
Department Of Organ Transplantation National Cardiovascular Center
-
Hanatani Akihisa
Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center
-
Nakatani Takeshi
Division Of Cardiovascular Surgery National Cardiovascular Center
-
Inagaki Masashi
Department Of Cardiovascular Dynamics National Cardiovascular Center
-
Hanatani Akihisa
National Cardiovascular Center Dep Of Organ Transplantation
-
Yutani Chikao
Department Of Life Science Faculty Of Science Okayama University Of Science
-
Nonogi Hiroshi
Department Of Cardiology Medical School Osaka University
-
Kimura Koji
Department Of Bioresource Science Obihiro University Of Agriculture And Veterinary Medicine
-
Yutani Chikao
Department Of Clinical Laboratory National Cardiovascular Center
-
Kimura Koji
Department Of Animal Breeding And Reproduction National Institute Of Livestock And Grassland Science
-
Yutani Chikao
The Department Of Pathology National Cardiovascular Center
-
Minatoya Kenji
Department Of Cardiac Surgery National Cerebral And Cardiovascular Center
-
HANATANI Akihisa
Department of Cardiology, Osaka City University School of Medicine
関連論文
- Clinical Course and Outcome of Heart Transplant Recipients : Single Center Experience at the National Cardiovascular Center in Japan
- Reversible Posterior Leukoencephalopathy Syndrome (RPLS) in a Heart Transplant Recipient Treated by Substitution of Cyclosporine A with Tacrolimus
- Experience of appendicular thermal therapy applied to a patient with a left ventricular assist device awaiting heart transplantation
- PJ-569 Long-term Results of Autologous Transplantation of Bone Marrow Mononuclear Cells for Patients with Thromboangiitis Obliterans(Peripheral circulation-6 (H) PJ96,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese
- Evaluation of Novel Micro-angiography for Clinical Therapeutic Angiogenesis(Angiogenesis 4 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- 2 Present Strategy for the Treatment of Profound Heart Failure : Long-term Support by Left Ventricular Assist Systems and Heart Transplantation(Therapeutic Strategy for Severe Heart Failure-From LVAD to Heart Transplantation-,Symposium 11 (SY-11) (H),The
- Sequence-based Analysis of the CYP2D6^*36-CYP2D6^*10 Tandem-type Arrangement, a Major CYP2D6^*10 Haplotype in the Japanese Population
- Stereoselective Effect of Amiodarone on the Pharmacokinetics of Racemic Carvedilol
- Pharmacokinetic Characteristics of Amiodarone in Long-Term Oral Therapy in Japanese Population(Biopharmacy)
- Novel Nonsynonymous Single Nucleotide Polymorphisms in the CYP2D6 Gene
- Seven Novel Single Nucleotide Polymorphisms in the Human SLC22A1 Gene Encoding Organic Cation Transporter 1 (OCT1)
- Fourteen Novel Single Nucleotide Polymorphisms in the SLC22A2 Gene Encoding Human Organic Cation Transporter (OCT2)
- Twelve Novel Single Nucleotide Polymorphisms in ABCB1/MDR1 among Japanese Patients with Ventricular Tachycardia who were Administered Amiodarone
- Myocardial Protection Via the Coronary Sinus : Long-Term Effects of Intermittent Coronary Sinus Occlusion as an Adjunct to Reperfusion in Acute Myocardial Infarction
- PJ-110 Transmural Heterogeneity of Global Gene Expression Profiles in Canine Failing Ventricular Myocardium(Heart failure, basic(05)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-091 Activation of AMP-activated Protein Kinase by Metformin Prevents Progression of Heart Failure in Dogs(Heart failure, basic(02)(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-352 The Preoperative Cardio-Renal-Anemia-Syndrome and Myocardial Fibrosis Have Negative Impact on Survival and Myocardial Recovery After Left Ventricular Assist Device Implantation(Heart failure, clinical(04)(M),Oral Presentation(English),The 72nd Annu
- Novel single nucleotide polymorphisms in the CYP2D6 gene associated with CYP2D6^*2 and/or CYP2D6^*10 alleles
- 3 Management of Hyperphosphatemia is an Important Novel Therapeutic Target in Chronic Heart Failure(Symposium 11 (SY-11) (M) Stroke and Cardiorenal Complications in Hypertension,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulatio
- Hemodynamic and Echocardiographic Evaluation of Orthotopic Heart Transplantation With the Modified Bicaval Anastomosis Technique
- 2 Present Strategy for the Treatment of Profound Heart Failure : Long-term Support by Left Ventricular Assist Systems and Heart Transplantation(Therapeutic Strategy for Severe Heart Failure-From LVAD to Heart Transplantation-,Symposium 11 (SY-11) (H),The
- OE-352 The Preoperative Cardio-Renal-Anemia-Syndrome and Myocardial Fibrosis Have Negative Impact on Survival and Myocardial Recovery After Left Ventricular Assist Device Implantation(Heart failure, clinical(04)(M),Oral Presentation(English),The 72nd Annu
- 3 Potential for Destination Therapy with Next Generation Left Ventricular Assist System (LVAS)(Impacts of latest developments of artificial organs/systems in the treatment of cardiovascular diseases,Topic 5 (TP-5) (IHD),Special Program,The 72nd Annual Sci
- 4 Cardiac rehabilitation in the management of patients with end-stage heart failure(Symposium 16 (SY-16) (H) Cardiac Rehabilitation : Innovative Approach to Improve Patient Care,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulatio
- 4 Long-term Use of Left Ventricular Assist System as a Bridge to Heart Transplant : Superior Survival Rate to REMATCH Trial(Symposium 8 (SY-08) (M) New Strategies for Management of Severe Heart Failure with New Devices and Surgery,Special Program,The 72nd
- OE-286 Which Factors Predict the Recovery of Natural Heart Function after Left Ventricular Assist System Insertion(Transplantation/LVAD-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-569 Long-term Results of Autologous Transplantation of Bone Marrow Mononuclear Cells for Patients with Thromboangiitis Obliterans(Peripheral circulation-6 (H) PJ96,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese
- 3 Management of Hyperphosphatemia is an Important Novel Therapeutic Target in Chronic Heart Failure(Symposium 11 (SY-11) (M) Stroke and Cardiorenal Complications in Hypertension,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulatio
- PJ-048 Development of New Parenteral Inotrope : β_2 Adrenergic Agonist in Sticky Tape-form(Heart failure, basic-7 (M) PJ8,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Preoperative Prediction of Myocardial Recovery by Left Ventricular Assist System(Frontier in Cardiovascular Surgery (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-600 Coronary flow reserve by transthoracic Doppler ultrasound can detect noninvasively acute cardiac allograft rejection in heart transplant recipients.(Transplantation 2 (M) : PJ101)(Poster Session (Japanese))
- Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension(Surgical Treatment for Chronic Pulmonary Thromboembolism, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Monoparesis after Graft Replacement of Non-Ruptured Abdominal Aortic Aneurysm
- Impact of the Fluid Balance on the Incidence of Postoperative Atrial Fibrillation After Aortic Arch Repair(Cardiovascular Surgery/CABG 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Current Challenge in Thromboendarterectomy for Chronic Pulmonary Thromboembolism with Pulmonary Hypertension ; Prompt Use of PCPS and MUF(Pulmonary Circulation 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- 3 Management of Hyperphosphatemia is an Important Novel Therapeutic Target in Chronic Heart Failure(Symposium 11 (SY-11) (M) Stroke and Cardiorenal Complications in Hypertension,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulatio
- Bone Marrow Cell Transplantation into the Heart is Not a Crucial Factor of Ventricular Fibrillation in a Rat Doxorubicin-Induced Cardiomyopathy Model
- Granulocyte-Colony Stimulating Factor Enhanced the Recruitment of Bone Marrow Cells into the Heart : Time Course Evaluation of Phenotypic Differentiation in the Doxorubicin-induced Cardiomyopathic Model
- Bone Marrow Cell-Seeded Biodegradable Polymeric Scaffold Enhanced Angiogenesis and Improved Cardiac Function of Infarcted Rat Heart
- G-CSF Promoted Bone Marrow Cells to Migrate into Infarcted Heart and Differentiate into Cardiomyocytes
- Trends in the Clinical and Morphological Characteristics of Cardiac Myxoma : 20-Year Experience of a Single Large Tertiary Referral Center in Japan
- Bone Marrow Stromal Cells Contract Synchronously With Cardiomyocytes in a Coculture System
- Application of tissue-engineering and regeneration medicine to heart and heart-valve diseases
- Cell-based therapy for end-staged heart failure from bench to bedside
- Cardiac Transplantation Under New Legislation for Organ Transplantation in Japan : Report of Two Cases
- Relationship Between Acute Rejection and Cyclosporine or Mycophenolic Acid Levels in Japanese Heart Transplantation
- Tiotropium, a Novel Muscarinic M3 Receptor Antagonist, Improved Symptoms of Chronic Obstructive Pulmonary Disease Complicated by Chronic Heart Failure
- 7 Next Generation LVAS as a Feasible Alternative to Heart Transplantation(Therapeutic Strategy for Severe Heart Failure-From LVAD to Heart Transplantation-,Symposium 11 (SY-11) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Is Diabetic Nephropathy a Predicted Risk Factor? : Kaplan-Meier and Multivariate Analysis of Confounding Risk Factors in Off-Pump Coronary Artery Bypass Grafting for Chronic Dialysis Patients
- Japanese multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system
- Is Prompt Surgical Treatment of an Abdominal Aortic Aneurysm Justified for Someone in Their Eighties?
- Total arch replacement through re-median sternotomy after coronary surgery
- Total Arch replacement Using Integrated Selective Cerebral Perfusion and a Stepwise Distal Anastomosis Technique(Peripheral Circulation/Vascular Disease 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Genetic risk factor for abdominal aortic aneurysm in the MHC Class 2
- Pulmonary Ventricular Outflow Reconstruction With a Size-Reduced Cryopreserved Pulmonary Valve Allograft : Mid-Term Follow-up
- PE-270 Therapeutic Monitoring of Mycophenolate Mofetile Dose by Twelve-Hour-Area Under the Curve to Avoid Acute Rejection in Heart Transplant Recipients(Transplantation/LVAD-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-291 Clinical Utility of Coronary Perfusion Reserve and Strain Obtained by Echocardiography for Sub-clinical Acute Rejection in Heart Transplant Recipients(Transplantation/LVAD-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-290 Time Lapse Analysis of Changes in Doppler-derived Index of Coronary Flow Reserve Over Time Could Reduce Frequency of Endomyocardial Biopsy(Transplantation/LVAD-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 日本人で新たに見いだされた低活性型CYP2D6ハプロタイプ
- Reconstruction of a friable posterior mitral annulus after removing a calcified artificial ring using flipover technique of the anterior mitral leaflet
- Successful Excision of a Cystic Tumor of the Atrioventricular Nodal Region
- Early Results of Off-pump Coronary Artery Bypass Grafting for Patients on Chronic Renal Dialysis
- The Impact of Early Mitral Valve Surgery Combined with Maze Procedure(Frontier in Cardiovascular Surgery (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Rationale of Off-pump Coronary Artery Bypass Grafting for Left Main Trunk Disease
- Comparison of Off-pump and On-pump Coronary Artery Bypass Grafting in Midterm Results
- 4 Heart Transplantation at National Cardiovascular Center : Hopes and Agonies(Plenary Session 8 (PL8) (IHD) : Toward Optimal Transplant Programs in Japan : from Cellular, Tissue and Solid Organ Aspects)(Special Program)
- Implantation of Collar-Reinforced SuMit Valve for Patient with Large Calcified Mass Obstructing the Mitral Valve Orifice
- Application of Surgical Options for Selected Severe Heart Failure Patients
- Perioperative Advantages of Off-Pump Coronary Artery Bypass Grafting
- Is Left Internal Thoracic Artery (LITA) Enough for Blood Source in Off-pump Composite Radial Arterial Total Coronary Revascularization
- Left Atrial Plication Combined with Mitral Valve Surgery in Patients with a Giant Left Atrium
- The role of a common TNNT2 polymorphism in cardiac hypertrophy
- The Valve Sparing Operation and the Bentall Operation : The Comparison in Middle Term Follow Up
- A Study on the Mechanism for Cavitation in the Mechanical Heart Valves with an Electrohydraulic Total Artificial Heart(Bioengineering)
- Observation of cavitation bubbles in monoleaflet mechanical heart valves
- Observation of alveolar fibrosis in a goat following venoarterial bypass for up to 5 months using extracorporeal membrane oxygenation
- 5 Nonspecific and Mystifying Causes of Dilated Cardiomyopathy(The Cause of Dilated Cardiomyopathy : Inflammation or Genetic,Controversy 2 (C-2) (M),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Neovascularization by Erythropoietin Contributes to the Preservation of Left Ventricular Function after Coronary Artery Ligation in Conscious Beagle Dogs(Angiogenesis 4 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Surgical Repair Of Pulmonary Arterial Sling Associated With Tetralogy Of Fallot
- OJ-033 Capability of Contrast-enhanced Sonography in the Assessment of Neovascularization after Mesenchymal Stem Cell Transplantation in Rat Model of Hindlimb Ischemia(Echo/Doppler(03)(I),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of t
- Mesenchymal Stem Cells for the Treatment of Heart Failure
- Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in Heart Failure Through Angiogenesis and Myogenesis(Cardiovascular Development, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-394 Intravenous Administration of Mesenchymal Stem Cells Improves Cardiac Function in Rats With Acute Myocardial Infarction Through Angiogenesis and Myogenesis(Angiogenesis 4 (IHD) : PE67)(Poster Session (English))
- Results from Coronary Artery Bypass Surgery Combined Abdominal Aortic Aneurysm Repair
- Results of Internal Mammary Artery-Coronary Artery Bypass Surgery and the Characteristics of Internal Mammary Artery Grafts : 50th Annual Scientific Session of the Japanese Circulation Society
- Repair of an Infected Aortic Aneurysm Using an Aortic Allograft and a Venous Autograft : Report of a Case
- Surgical Treatment of Mycotic Aortic Aneurysms and Management of Aortic Graft Infections
- Pre- and Postoperative Hemodynamic Assessments and Survival Rates in Patients with Postinfarction Ventricular Septal Perforation : The Effectiveness and Limitations of Coronary Care Unit
- Functional Status in Adolescents and Adults With Fontan Circulation
- 5 Therapeutic Potential of Mesenchymal Stem Cell Transplantation in Heart Failure(Cell Death and Repair-Regeneration in Cardiac and Vascular Diseases,Plenary Session 3 (PL3) (M),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation So
- OJ-246 New Era of Medical Tourism : International Comparison of Surgical Cost for Heart Transplantation(Cost-health care system (H),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Progressive Dilatation of Ascending Aorta After Aortic Valve Replacement in Patients With Bicuspid Aortic Valve : Comparison With Tricuspid Aortic Valve
- Risk Factor Analysis of Early and Late Stroke after Mechanical Mitral Valve Replacement : A 24-year experience
- Comparative Left Ventricular Functional and Neurohumoral Effects of Chronic Treatment With Carvedilol Versus Metoprolol in Patients With Dilated Cardiomyopathy
- Successful Surgical Treatment for Aneurysm of Splenic Artery with Anomalous Origin
- Thoracic and Cardiovascular Surgery in Japan during 1999 : Annual Report by The Japanese Association for Thoracic Surgery
- Is an Increase in Lactate Concentration Associated with Cardiac Dysfunction after the Fontan Procedure?
- Impact of Serum Insulin-like Growth Factor-1 on Early Prognosis in Acute Myocardial Infarction
- Improved long-term performance of pulsatile extracorporeal left ventricular assist device
- Efficacy of a Heparin-Coated Closed Circuit for Intractable Bleeding in Adult Cardiac Surgery