Reversible Posterior Leukoencephalopathy Syndrome (RPLS) in a Heart Transplant Recipient Treated by Substitution of Cyclosporine A with Tacrolimus
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概要
- 論文の詳細を見る
Reversible posterior leukoencephalopathy syndrome (RPLS) is one of the important adverse events following organ transplantation, associated with calcineurin inhibitors (CNIs). We describe a case of 54-year-old woman, who was diagnosed with RPLS within weeks after transplantation. Considering the risk of causing fatal rejection by discontinuation of CNIs, the immunosuppressive regimen of the patient was switched from a cyclosporine A-based regimen to a tacrolimus-based regimen. The patient recovered rapidly from RPLS following the switch to tacrolimus. This case demonstrated that not only discontinuation but also a substitution of CNIs would be a valid treatment option for RPLS in transplant recipients.
著者
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KITAMURA Soichiro
Department of Cardiovascular Surgery, National Cardiovascular Center
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Kitakaze Masafumi
Department Of Cardiology National Cardiovascular Center
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Hashimura Kazuhiko
Department of Cardiology, National Cardiovascular Center
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Niwaya Kazuo
Department Of Cardiovascular Surgery National Cardiovascular Center
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Oda Noboru
Department Of Cardiology Hiroshima University School Of Medicine
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Komamura Kazuo
Department Of Cardiology National Cardiovascular Center
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Ishibashi-ueda Hatsue
Department Of Cardiology Pathology Organ Transplantation And Nuclear Medicine National Cardiovascula
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Kato Tomoko
Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
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Nakatani Takeshi
Department Of Cardiology Pathology Organ Transplantation And Nuclear Medicine National Cardiovascula
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Kitamura Soichiro
Department Of Cardiology National Cardiovascular Center
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Hanatani Akihisa
Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center
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Niwaya Kazuo
Department of Cardiovascular Surgery, National Cardiovascular Center
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Hashimura Kazuhiko
Department of Cardiovascular Medicine, National Cardiovascular Center
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Komamura Kazuo
Department of Cardiovascular Medicine, National Cardiovascular Center
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Kato Tomoko
Department of Cardiovascular Medicine, National Cardiovascular Center
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Oda Noboru
Department of Cardiovascular Medicine, National Cardiovascular Center
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Kitakaze Masafumi
Department of Cardiovascular Medicine, National Cardiovascular Center
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Hanatani Akihisa
Department of Cardiovascular Medicine, National Cardiovascular Center
関連論文
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- Reversible Posterior Leukoencephalopathy Syndrome (RPLS) in a Heart Transplant Recipient Treated by Substitution of Cyclosporine A with Tacrolimus
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