Clinical Course and Outcome of Heart Transplant Recipients : Single Center Experience at the National Cardiovascular Center in Japan
スポンサーリンク
概要
- 論文の詳細を見る
The number of heart transplant (HTx) surgeries in Japan is expected to increase under the Revised Organ Transplant Law. To date, among 69 HTx surgeries performed in Japan, 27 operations (39.1%) were performed at our institution, the National Cardiovascular Center (NCVC), located in Osaka. We have reviewed the outcomes of HTx conducted at NCVC during a 10 year period (May 1999 to January 2009). Among 27 heart transplant recipients at NCVC, the clinical charts of 26 recipients whose post-HTx period exceeded 1 year were retrospectively reviewed and compared to data from the International Society for Heart and Lung Transplantation (ISHLT) Registry. The survival rate of our recipients was 96.2% at 10.8 years, which was excellent even compared to the ISHLT Registry. The immunosuppressive regimen at NCVC was equivalent to that of the ISHLT Registry, except for more frequent use of Muromonab-CD3 (26.9% versus 3.3%, P < 0.0001) and an initial CSA-based regimen (65.3% versus 34.4%, P < 0.001). The drug we use for induction therapy has been recently changed from Muromonab-CD3 to Basiliximab. The incidences of post-HTx hypertension, diabetes, hyperlipidemia, and renal insufficiency were significantly less in patients at NCVC compared to those in the ISHLT Registry, however, the incidence of transplant coronary artery disease (TxCAD) was almost identical. Clinical review of post-HTx outcome at NCVC can provide useful information for Japanese transplant cardiologists who will engage in HTx management.
著者
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KOMAMURA Kazuo
Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center
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ODA Noboru
Department of Organ Transplantation, National Cardiovascular Center
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KATO Tomoko
Department of Organ Transplantation, National Cardiovascular Center
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MANO Akiko
Department of Organ Transplantation, National Cardiovascular Center
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HASHIMOTO Shuji
Department of Physiologic Laboratory, National Cardiovascular Center
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WADA Kyoichi
Department of Organ Transplantation, National Cardiovascular Center
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Nakano Yukiko
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Science
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Kihara Yasuki
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Science
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Ishibashi-Ueda Hatsue
Department of Pathology, National Cardiovascular Center
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Kitakaze Masafumi
Department Of Cardiology National Cardiovascular Center
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ASAKURA Masanori
Department of Research and Development of Clinical Research, National Cardiovascular Center
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Hashimura Kazuhiko
Department of Cardiology, National Cardiovascular Center
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Kobayashi Junjiro
Department of Cardiac Surgery, National Cardiovascular Center
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Funatsu Toshihiro
Department of Cardiology, National Cardiovascular Center
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Niwaya Kazuo
Department of Organ Transplantation
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Hanatani Akihisa
Department of Organ Transplantation
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Niwaya Kazuo
Department Of Cardiovascular Surgery National Cardiovascular Center
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Oda Noboru
Department Of Cardiology Hiroshima University School Of Medicine
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Hashimura Kazuhiko
国立循環器病研究センター 心臓血管内科部門
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Hanatani Akihisa
国立循環器病研究センター 心臓血管内科部門
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Komamura Kazuo
Department Of Cardiology National Cardiovascular Center
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Wada Kyoichi
Department Of Organ Transplantation National Cardiovascular Center
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Ishibashi-ueda Hatsue
Department Of Cardiology Pathology Organ Transplantation And Nuclear Medicine National Cardiovascula
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Kato Tomoko
Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
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Kobayashi Junjiro
Department Of Applied Physics School Of Science And Engineering Waseda University
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Kihara Yasuki
Department Of Cardiology Graduate School Of Medicine Kyoto University
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Nakano Yukiko
Department Of Biostructural Science Graduate School Of Tokyo Medical And Dental University
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Mano Akiko
Department Of Cardiovascular Medicine Heart Failure Division National Cerebral And Cardiovascular Ce
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Hashimoto Shuji
Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University
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Hanatani Akihisa
Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center
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Asakura Masanori
Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center
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Nakano Yukiko
Department of Cardiovascular Medicine, Hiroshima University Hospital
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Mano Akiko
Department of Cardiovascular Medicine, National Cardiovascular Center
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Funatsu Toshihiro
Department of Cardiovascular Surgery, National Cardiovascular Center
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Asakura Masanori
Department of Cardiovascular Medicine, National Cardiovascular Center
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Wada Kyoichi
Department of Pharmacology, National Cardiovascular Center
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