Clinical Protocol for Angiogenesis by Intramyocardial Injection of Autologous Bone Marrow Mononuclear Cells in Patients With Severe Coronary Artery Disease : TACT-NAGOYA-HEART

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概要

• 論文の詳細を見る

• Background Despite recent improvements in the treatments of coronary artery disease (CAD), there are a considerable number of patients who can not receive complete revascularization because of severe or total arterial occlusion. Intramyocardial injection of autologous bone marrow mononuclear cells (ABMMCs) has been shown to induce neovascularization of ischemic myocardium. Methods and Results The study will investigate the safety and feasibility of intramyocardial injections of ABMMCs and test the hypothesis that this treatment would promote neovascularization and improve left ventricular (LV) global and/or regional function in patients with severe CAD who have no other option. ABMMCs (〜10^6 cells) will be injected into the area of ischemic myocardium where the coronary artery is not graftable, in combination with bypass surgery to the other coronary branches. Myocardial perfusion and LV global and regional function will be evaluated, based on the micromanometer-tipped catheter method, single-photon emission tomography, and myocardial enhanced and color tissue Doppler echocardiography at baseline and during 12 month follow-up. Conclusions This project will demonstrate that intramyocardial injection of ABMMCs with or without coronary artery bypass surgery could be a safe and effective method for therapeutic neovascularization, resulting in an improvement of cardiac function in patients with severe CAD.

• 社団法人日本循環器学会の論文
• 2006-08-20

著者

• KATO Tomoko

  Department of Organ Transplantation, National Cardiovascular Center

• MUROHARA Toyoaki

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Ukimura Akira

  Department Of Internal Medicine Iii Osaka Medical College

• SHINTANI Satoshi

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Uemura Akihisa

  Fujita Ezetimibe Study Assembly (festa)

• Isobe Satoshi

  名古屋第二赤十字病院 循環器内科

• Ichimiya Satoshi

  Department Of Cardiology Yokkaichi Municipal Hospital

• Isobe Satoshi

  Department Of Cardiology Kami-iida Daiichi General Hospital

• Yamamoto Koji

  Department of Internal Medicine, Hattori Memorial Hospital

• TAKAMATSU Junki

  Department of Transfusion Medicine, Cardiology and Hematology, Nagoya University Hospital

• Isobe S

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Inden Yasuya

  Department of Cardiology, Nagoya University School of Medicine

• Kondo Takahisa

  Department of Cardiology, Nagoya University School of Medicine

• Kadowaki Takashi

  滋賀大学 医学部健康科学科

• Isobe Satoshi

  Department Of Cardiology Nagoya University School Of Medicine

• YAMAMOTO Koji

  Division of Transfusion Medicine, Nagoya University Hospital

• Kajiguchi Masahiro

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Komori Kimihiro

  Department of Vascular Surgery, Nagoya University Graduate School of Medicine

• NODA Akiko

  Nagoya University School of Health Sciences

• Okumura Kenji

  Department of Cardiology, Nagoya University School of Medicine

• Unno Kazumasa

  Department Of Cardiology Nagoya University

• Toyama J

  Aichi Prefecture Hospital

• Takamatsu Junki

  Department Of Transfusion Medicine Cardiology And Hematology Nagoya University Hospital

• Toyama Junji

  名古屋大学 大学院医学系研究科循環器内科

• Toyama Junji

  名古屋大学環境医学研究所

• Toyama Junji

  Nagoya University

• Obata Koji

  名古屋大学 循環器内科

• Noda A

  Nagoya University School Of Health Sciences

• Kato Tomoko

  Department Of Organ Transplantation National Cardiovascular Center

• Izawa Hideo

  Division Of Cardiology Fujita Health University Hospital

• Izawa Hideo

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Inden Yasuya

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Kondo Takahisa

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Murohara Toyoaki

  Department Of Cardiology Nagoya University Graduate School Of Medicaine

• Isobe Satoshi

  Department Of Cardiology Kami-iida Dai-ichi General Hospital

• Ichimiya Satoshi

  Department Of Cardiology Kami-iida Daiichi General Hospital

• Toyama Junji

  Department Of Information And Computer Science Toyohashi University Of Technology

• Isobe Satoshi

  Department Of Cardiology Kami-iida Daiichi General Hospital:department Of Cardiology Nagoya Universi

• Kato Tomoko

  Department Of Biological Sciences Graduate School Of Science The University Of Tokyo

• Okumura Kenji

  Department O Pediatrics Graduate School Of Medical Science Kumamoto University

• Usui Akihiko

  Cardiothoracic Surgery, Nagoya University Graduate School of Medicine

• Naoe Tomoki

  Hematology and Oncology, Nagoya University Graduate School of Medicine

• Komori Kimihiro

  Vascular Surgery, Nagoya University Graduate School of Medicine

• Ueda Yuichi

  Cardiothoracic Surgery, Nagoya University Graduate School of Medicine

• Noda Akiko

  School Of Health Sciences

• Izawa Hideo

  Department Of Cardiology

• Komori Kimihiro

  Department Of Vascular Surgery Nagoya University Graduate School Of Medicine

• Komori Kimihiro

  Vascular Surgery Nagoya University

• Takamatsu Junki

  Aichi Red Cross Blood Center

• Kato Tomoko

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Kajiguchi Masahiro

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Takagi Kenzo

  Third Division Of The Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku Un

• Takamatsu J

  Division Of Transfusion Medicine Nagoya University Hospital

• Katou Tomoko

  Division Of Organ Transplantation National Cardiovascular Center

• Katoh Toshiaki

  Aich Cardiovascular And Respiratory Center

• Ueda Yuichi

  Cardiothoracic Surgery Nagoya University Graduate School Of Medicine

• Yamamoto Koji

  Division Of Transfusion Medicine Nagoya University Hospital

• Toyama J

  Aichi Red Cross Blood Center

• Toyama Junji

  Department Of Cardiology Toyohashi Heart Center

• Takamatsu Junki

  Department Of Blood Transfusion Nagoya University Hospital

• Usui Akihiko

  Cardiothoracic Surgery Nagoya University Graduate School Of Medicine

• Shintani Satoshi

  Departmdepartment Of Cardiology Nagoya University Graduate School Of Medicine

• Isobe Satoshi

  Division Of Cardiology First Department Of Internal Medicine Nagoya University Graduate School Of Me

• Takagi Katsumasa

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Murohara Toyoaki

  Department Of Cardiology Nagoya Graduate School Of Medicine

• Nakano Tatsunori

  Second Departmant Of Medicine Nagoya City University Medical School

• Unno Kazumasa

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Kato Tomoko

  Organ Transplantation National Cardiovascular Center

• Kondo Takahisa

  Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University Graduate School of Medicine

• Yamamoto Koji

  Department of Cardiology, Nagoya City University Medical School

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