Safety and Efficacy of Autologous Progenitor Cell Transplantation for Therapeutic Angiogenesis in Patients With Critical Limb Ischemia
スポンサーリンク
概要
- 論文の詳細を見る
Background Therapeutic angiogenesis using cell transplantation (TACT) is a treatment strategy for no-option patients with critical limb ischemia (CLI). However, because one-third of treated patients fail to respond, the present study was an exploration of the characteristics of responders and non-responders to this treatment regimen. Methods and Results Seven CLI patients (3 with Buerger's disease, 4 with arteriosclerosis obliterans undergoing chronic hemodialysis (ASO-HD)) were treated according to the TACT protocol (n=6: bone marrow-mononuclear cells (MNCs); n=1: peripheral blood-MNCs). Subjective symptoms (visual analog scale) and objective findings (extent of ulcer, ankle-brachial pressure index, transcutaneous oxygen pressure, thermography and angiography) were assessed. Numbers of transplanted CD34^+, CD133^+ and CD34^+CD133^+ cells were counted. Changes in circulating CD34^+ and CD133^+ cell numbers were also examined before and after the treatment. All responders (n=3) had Buerger's disease, and ASO-HD patients did not respond well. Among the responders, the numbers of circulating CD34^+ and CD133^+ cells persistently increased for 1 month after the treatment, but not in non-responders. Conclusions The TACT regimen improved CLI in patients with Buerger's disease but not in those with ASO-HD in this small study. In responders, post procedural circulating CD34^+ and CD133^+ cells persistently increased for 1 month (Clinical Trials. gov Identifier: NCT00145262, TACT-NAGOYA).
- 2007-01-20
著者
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MUROHARA Toyoaki
Department of Cardiology, Nagoya University Graduate School of Medicine
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NAOE Tomoki
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine
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SHINTANI Satoshi
Department of Cardiology, Nagoya University Graduate School of Medicine
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Yamamoto Koji
Department of Internal Medicine, Hattori Memorial Hospital
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Tsuboi Naoya
Department Of Hematology And Oncology Nagoya University Graduate School Of Medicine
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Izawa Hideo
Department of Cardiology, Fujita Health University, Banbuntane Hotokukai Hospital
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TAKAMATSU Junki
Department of Transfusion Medicine, Cardiology and Hematology, Nagoya University Hospital
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Tsuboi Naoya
Division Of Cardiology Nagoya Daini Red Cross Hospital
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Kondo Takahisa
Department of Cardiology, Nagoya University School of Medicine
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Kadowaki Takashi
滋賀大学 医学部健康科学科
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YAMAMOTO Koji
Division of Transfusion Medicine, Nagoya University Hospital
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Kajiguchi Masahiro
Department of Cardiology, Nagoya University Graduate School of Medicine
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Kobayashi Masayoshi
Department of Vascular Surgery, Nagoya University Graduate School of Medicine
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Numaguchi Yasushi
Department of Medical Science of Proteases, Nagoya University Graduate School of Medicine
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Komori Kimihiro
Department of Vascular Surgery, Nagoya University Graduate School of Medicine
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Toyama J
Aichi Prefecture Hospital
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Takamatsu Junki
Department Of Transfusion Medicine Cardiology And Hematology Nagoya University Hospital
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Toyama Junji
名古屋大学 大学院医学系研究科循環器内科
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Toyama Junji
名古屋大学環境医学研究所
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Toyama Junji
Nagoya University
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Izawa Hideo
Division Of Cardiology Fujita Health University Hospital
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Izawa Hideo
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Kondo Takahisa
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Murohara Toyoaki
Department Of Cardiology Nagoya University Graduate School Of Medicaine
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Numaguchi Yasushi
Department Of Medical Science Of Proteases Nagoya University School Of Medicine
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Numaguchi Yasushi
Department Of Cardiology Ogaki Municipal Hospital
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Izawa Hideo
Department Of Cardiology
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Komori Kimihiro
Department Of Vascular Surgery Nagoya University Graduate School Of Medicine
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Komori Kimihiro
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
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Naoe Tomoki
Department Of Hematologly And Oncology Nagoya University School Of Medicine
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Takamatsu Junki
Aichi Red Cross Blood Center
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Kajiguchi Masahiro
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Takagi Kenzo
Third Division Of The Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku Un
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Takamatsu J
Division Of Transfusion Medicine Nagoya University Hospital
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Takemiya Kiyoko
Department Of Internal Medicine Division Of Cardio-vascular Medicine Kurume University School Of Med
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Yamamoto Koji
Division Of Transfusion Medicine Nagoya University Hospital
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Toyama J
Aichi Red Cross Blood Center
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Toyama Junji
Department Of Cardiology Toyohashi Heart Center
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Izawa Hideo
Department Of Cardiovascular Medicine Nagoya University Graduate School Of Medicine
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Takamatsu Junki
Department Of Blood Transfusion Nagoya University Hospital
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Kobayashi Masayoshi
Departmdepartment Of Cardiology Nagoya University Graduate School Of Medicine
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Shintani Satoshi
Departmdepartment Of Cardiology Nagoya University Graduate School Of Medicine
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Murohara Toyoaki
Department Of Cardiology Nagoya Graduate School Of Medicine
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Nakano Tatsunori
Second Departmant Of Medicine Nagoya City University Medical School
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Numaguchi Yasushi
Medical Science Of Proteases Nagoya University Graduate School Of Medicine
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Kondo Takahisa
Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University Graduate School of Medicine
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Yamamoto Koji
Department of Cardiology, Nagoya City University Medical School
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