Preparation of New Nitrogen-Bridged Heterocycles. 55. Reinvestigation of the Bromination/Dehydrobromination of Ethyl 3-[2-(Methylthio)indolizin-3-yl] acrylate Derivatives
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概要
- 論文の詳細を見る
The bromination/dehydrobromination reactions of ethyl 3-[1-alkoxycarbonyl-2-(methylthio)indolizin-3-yl]acrylates were reinvestigated. Reactions of the title compounds with two equivalents of bromine, followed by heating of the resulting reaction mixture and then treatment with a base gave the unexpected dialkyl 7-bromothieno[2,3-b]indolizine-2,9-dicarboxylates, while similar reactions using benzyltrimethylammonium tribromide as a brominating agent afforded only non-brominated thieno[2,3-b]indolizine derivatives, which were converted to the corresponding 7-bromo derivatives upon further treatment with bromine.
- 社団法人日本薬学会の論文
- 2004-02-01
著者
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Suga Hiroyuki
Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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Suga H
Department Of Physiology Ii Okayama University Medical School
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Kakehi A
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Zuo Peng
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Akikazu Kakehi
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Kakehi Akikazu
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Suga Hiroyuki
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Kakehi A
Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855
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ITO Suketaka
Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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KOBAYASHI Yuhichi
Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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IRIYE Ryozo
Department ofBioscience and Biotechnology, Faculty of Agriculture, Shinshu University
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Suga H
Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855
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Iriye Ryozo
Department Of Agricultural Chemistry Faculty Of Agriculture University Of Mie
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Iriye Ryozo
Department Ofbioscience And Biotechnology Faculty Of Agriculture Shinshu University
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Ito Suketaka
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Kobayashi Y
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Kobayashi Yuhichi
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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SUGA Hiroyuki
Department of Cardiac Physiology, National Cardiovascular Center Research Institute
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Ito Suketaka
Department of Applied Chemistry Faculty of Engineering Nagoya University
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IRIYE Ryozo
Department of Agricaltural Chemistry, Faculty of Agriculture, Shinshu University
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