Preparation of New Nitrogen-Bridged Heterocycles 72. A New Approach to 1-Acyl-3-(substituted methylthio)thieno[3′,4′:4,5]imidazo[1,5-a]pyridine Derivatives
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概要
- 論文の詳細を見る
The alkaline treatment of the pyridinium salts, readily available from the S-alkylations of 3-amino-4-(1-pyridinio)thiophene-5-thiolates with various alkyl halides, in chloroform at room temperature afforded the corresponding thieno[3′,4′:4,5]imidazo[1,2-a]pyridine derivatives in low to moderate yields via the intramolecular cyclization of the resulting 1,5-dipoles followed by the aromatization of the primary cycloadducts. Interestingly, the reactions using unsymmetrical 3-amino-4-[1-(3-methylpyridinio)]thiophene-5-thiolates afforded only 8-methylthieno[3′,4′:4,5]imidazo[1,2-a]pyridines and the other 6-methyl derivatives were not formed at all. In addition the isolation of a byproduct in the condensation reaction of pyridinium salt with the solvent (CHCl3) is also discussed.
- 社団法人 日本薬学会の論文
著者
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Suga Hiroyuki
岡山大学 医歯総研究 麻酔蘇生学
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Suga Hiroyuki
Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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Suga H
Department Of Physiology Ii Okayama University Medical School
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Okumura Yukihisa
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Suga Hiroyuki
Department Of Systems Physiology Okayama University Graduate School Of Medicine Dentistry And Pharma
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KAKEHI Akikazu
Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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Akikazu Kakehi
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Kakehi Akikazu
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Suga H
Department Of Systems Physiology Okayama University Graduate School Of Medicine Dentistry And Pharma
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Suga Hiroyuki
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Kakehi A
Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855
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Itoh Kennosuke
Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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Kobayashi Kouji
Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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Aikawa Yoshihiro
Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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Misawa Kotaro
Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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Suga H
Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855
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Suga Hiroyuki
Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855
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SUGA Hiroyuki
Department of Cardiac Physiology, National Cardiovascular Center Research Institute
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