DENOPAMINE (BETA_1-SELECTIVE ADRENERGIC RECEPTOR AGONIST) AND ISOPROTERENOL (NON-SELECTIVE BETA-ADRENERGIC RECEPTOR AGONIST) EQUALLY INCREASE HEART RATE AND MYOCARDIAL OXYGEN CONSUMPTION IN DOG HEART
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概要
- 論文の詳細を見る
The effects of denopamine (a beta_1-selective adrenergic receptor agonist) and isoproterenol (a non-selective beta-adrenergic receptor agonist) on heart rate. left ventricular contractility, and left ventricular oxygen consumption (VO_2) at the same left ventricular volume were compared in excised cross-circulated dog hearts. Denopamine and isoproterenol increased heart rate and VO_2 to a comparable extent at a comparably increased contractility. Moreover, the oxygen cost of contractility which quantifies VO_2 for excitation-contraction coupling was the same between the two agents. These findings contradict the previously reported smaller increases in heart rate and VO_2 by denopamine than by isoproterenol in open-chest dog hearts, which have been mainly attributed to the beta_1-selectivity of denopamine. Our results suggest that in isolated and denervated hearts. the degree of beta_1-selectivity of a beta-agonistic agent does not directly determine the relative potencies of its inotropic and chronotropic effects and the oxygen cost of contractility.
- 社団法人日本循環器学会の論文
- 1991-10-20
著者
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yaku hitoshi
Department of Cardiovascular Surgery, Kyoto Prefectural University School of Medicine
-
Goto Yoichi
Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute
-
Suga Hiroyuki
Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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Yaku Hitoshi
Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute
-
Suga H
Department Of Systems Physiology Okayama University Graduate School Of Medicine Dentistry And Pharma
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KAWAGUCHI Osamu
Department of Radiology, Keio University
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Fukui Sugao
National Cardiovascular Center Research Institute
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Fukui Sugao
和泉市
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Fukui Sugao
Division Of Cardiology Sakurabashl Watanabe Hospital
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Futaki Shiho
National Cardiovascular Center Research Institute
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Goto Yoichi
The Departments Of Cardiovascular Dynamics And Internal Medicine National Cardiovascular Center
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FUTAKI SHIHO
Department of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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OHGOSHI YUICHI
Department of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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Goto Yoichi
Department Of Cardiology National Cardiovascular Center
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Kawaguchi Osamu
Department Of Cardiovascular Dynamics National Cardiovascular Center
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Kawaguchi Osamu
Department Of Cardiac Surgery Aichi Medical University
-
Fukui Sugao
The Department Of Cardiovascular Dynamics National Cadiovascular Center
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Ohgoshi Yuichi
Department Of Biology Faculty Of Science Chiba University
-
Fukui Sugao
The Division Of Cardiology Sakurabashi Watanabe Hospital
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Goto0 Yoichi
National Cardiovascular Center
-
Kawaguchi Osamu
Department Of Applied Chemistry Faculty Of Engineering Saitama University
-
SUGA Hiroyuki
Department of Cardiac Physiology, National Cardiovascular Center Research Institute
-
Yaku Hitoshi
Department of Cardiovascular and Thoracic Surgery, Kyoto Prefectural University of Medicine
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