Preparation of New Nitrogen-Bridged Heterocycles.51.^<1)> Syntheses and Structures of Compounds Having Two Indolizine Nuclei in a Molecule

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New compounds having two indolizine nuclei in a molecule were prepared in low to moderate yields from the reactions of potassium 2-indolizinethiolates with 1, ω-dihalides such as 1, 2-diiodoethane, 1, 3-dibromopropane, 1, 4-dibromobutane, α, α'-dichloro-o-xylene, and α, α'-dichloro-p-xylene. Most of the products had the conformation in which the two indolizine rings in the molecule are as remote as possible, but only 1, 2-bis[[(2-in-dolizinyl)thio]methyl]benzene derivatives, prepared from potassium 2-indolizinethiolates and α, α'-dichloro-o-xylene, showed a weak attractive interaction between the two indolizine nuclei in the X-ray analysis and the nuclear Overhauser and exchange spectroscopy (NOESY) spectrum.
公益社団法人日本薬学会の論文
2001-11-01