Reductive cyclization of 8-(2-nitrophenyl)-1-azaazulene derivatives; formation of 6a,7-diazanaphth[3,2,1-cd]azulene and 7H-1,7-diazaindeno[1,2-e]azulene systems, a new DNA intercalater
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概要
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Reaction of ethyl 2-dimethylamino-8-(2-nitrophenyl)-1-azaazulene-3-carboxylate with hexamethylphosphorous triamide gave ethyl 6-dimethylamino-6a,7-diazanaphth[3,2,1-cd]azulene-5-carboxylate (7b) and ethyl 2-dimethylamino-7H-1,7-diazaindeno[1,2-e]azulene-3-carboxylate (8b). The structures of 7b and 8b were determined by X-Ray structure analyses. Compound (8b) was intercalated to Calf-Thymus DNA and a 12-mer DNA with binding constants K_D=1.55×10^6 and 1.75×10^6 M^<-1>, respectively.
- 日本複素環化学研究所の論文
著者
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Kakehi A
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Akikazu Kakehi
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Fujii Hiroyuki
Yamaguchi Univ. Yamaguchi Jpn
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Konakahara Takeo
Faculty Of Science And Technology Tokyo University Of Science (rikadai)
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Abe Noritaka
Tokyo Univ. Sci. Chiba Jpn
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