Palladium-catalyzed heteroarylamination of ethyl 2-chloro-1-azaazulene-3-carboxylate and annulation of heteroarylamino-1-azaazulenes
スポンサーリンク
概要
- 論文の詳細を見る
The palladium catalyzed heteroarylamination of ethyl 2-chloro-1-azaazulene-3-carboxylate was achieved using a catalyst based on Pd2(dba)3 / Xantphos system. Treatment of ethyl 2-(heteroarylamino)-1-aza-azulene-3-carboxylates with a PPA-POCl3 mixture gave corresponding annulation products. 2-(2-Benzothiazolylamino)-1-azaazulene (3h) showed anticancer activity against HeLa S3 cells (IC50: 6.5 μM).
- 日本複素環化学研究所の論文
著者
-
Fujii Hiroyuki
Yamaguchi Univ. Yamaguchi Jpn
-
Konakahara Takeo
Faculty Of Science And Technology Tokyo University Of Science (rikadai)
-
Abe Noritaka
Tokyo Univ. Sci. Chiba Jpn
関連論文
- Synthesis and Reactions of 3-Ethynyl-2-(Triphenylphosphoimino)-1-azaazulenes
- Highly Efficient and Vivid-Red Phosphors Bearing 2,3-Diphenylquinoxaline Units and Their Application to Organic Light-Emitting Devices(Characterization of Organic Devices)(Recent Progress in Organic Molecular Electronics)
- 1P057 アルツハイマー病アミロイドβの同位体ラベルを用いた赤外分光法による構造解析(蛋白質-物性(安定性,折れたたみなど),第48回日本生物物理学会年会)
- Reactions of 8-(Triphenylphosphoimino)quinoline with Aryl Aldehydes and Aryl Isocyanates : Formation of 2-Aryl-4H-imidazo[4,5,1-ij]quinolines and Related Systems
- Reactions of 2-Triphenylphosphoimino-1-azaazulenes with Aryl Isocyanates and Aryl Isothiocyanates
- Reactions of 2-Triphenylphosphoimino-1-azaazulenes with Aryl Isocyanates and Aryl Isothiocyanates
- Structural Analysis on Amyloid Fibril of Amyloid-β(1-42) by Systematic Isotope Labeling
- FT-IR Study on Secondary Structure of Self-Assembled Amyloid-β by Specific Isotope Labeling
- 2P130 Structural analysis of fibril-forming Alzheimer's amyloid-β(31. Protein folding and misfolding (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- Synthesis and some reactions of 11-azacyclohept[a]azulen-3(3H)-ones and evaluation of their cytotoxic activity against HeLa S3 cells
- Palladium-catalyzed heteroarylamination of ethyl 2-chloro-1-azaazulene-3-carboxylate and annulation of heteroarylamino-1-azaazulenes
- Synthesis of [poly(2-pyridyl)-substituted]-1-azaazulenes
- Heteroarylamination and heteroarylsulfidation of 2-chloro-1-azaazulenes
- Syntheses of 2-Formyl-, 2,3-Diformyl- and 8-Formyl-1-azaazulenes
- Cycloaddition Reactions of 1-Aza- and 1,3-Diazaazulenium 1-Methylides
- Synthesis and some properties of phosphoimino-1-azaazulene derivatives
- Amyloid Formation of Tyrosine-Mutant Amyloid-β(1-42)
- Some Reactions of 3-Phenyl-8-triphenylphosphoimino-1-azaazulene
- Facile synthesis of (2-Benzimidazolyl)-1-azaazulenes, (2-Benzothiazolyl)-1-azaazulenes, and related compounds and evaluation of their anticancer in vitro activity
- Facile synthesis of (2-benzimidazolyl)-1-azaazulenes, (2-benzothiazolyl)-1-azaazulenes, and related compouds and evaluation of their anticancer in vitro activity
- Synthesis of Aryl Conjugated (1-Azaazulenyl)acetylenes and Facile Synthesis of Thiophene Fused 1-Azaazulenes
- Reactions of 3-phenyl-8-triphenylphosphoimino-1-azaazulene with aryl isocyanate, aryl isothiocyanate, and carbon disulfide
- Synthesis of 2-chloro-8-(2-pyridyl)-1-azaazulene and its metal complexes
- Generation and reactions of 3-phenyl-7,8-dehydro-1-azaazulene
- First synthesis and cycloaddition reactions of 1-azaazulene N-ylide
- Peptide Library Analysis on Amyloid Formation Dependent on Sequences of Peripheral Region Neighboring Core Cross-β Domain
- Special Arrangement of Amino Acid Residues Responsible for Intra- and Intermolecular Structure Formation of Amyloid Fibrils
- A Model for Characteristic Arrangement of Interacting Amino Acid Residues to Form Amyloid-like Fibrils
- Elemental structural model of the peptide fragment forming amyloid-like fibrils
- The separation of Platinum(II), Palladium(II) and Rhodium(III) by surfactant gel extraction and an abnormal dependence of metal concentrations on the extractability of chloro-complexes into the cationic surfactant phase
- IR Analysis on Amyloids of Isotope-Labeled Amyloid β Peptides
- Iridium(III) Complexes Bearing Quinoxaline Ligands with Efficient Red Luminescence Properties
- Synthesis and some reactions of ethyl (2-alkylimino-1,2-dihydro-1-azaazulen-1-yl)acetates
- Synthesis and reactions of 3- and 8-ethynyl-1-azaazulenes
- Reductive cyclization of 8-(2-nitrophenyl)-1-azaazulene derivatives; formation of 6a,7-diazanaphth[3,2,1-cd]azulene and 7H-1,7-diazaindeno[1,2-e]azulene systems, a new DNA intercalater
- Analysis on Inter-Molecular Alignment in Amyloids Using Systematic Tyrosine Mutation for Amyloid β
- Reaction of 2-chloro-1-azaazulene with diphenylcyclopropenone; Dimerization of the cycloadduct attended by cine-substitution and rearrangement
- Development of Micelle-Forming Peptides as Novel System Assisting the Refolding of Proteins
- Micelle-Forming Proteins Designed to Bind Hydrophobic Molecules
- Cycloaddition Reactions of 1-Aza- and 1,3-Diazaazulenium 1-Methylides
- Synthesis and some reactions of 1,8-diamino-1-azaazulenium salts
- The separation of Platinum(II) and Palladium(II) by surfactant gel extraction (Part II)
- Reaction of 2-hydrazino-1-azaazulene with diphenylnitrone : unexpected formation of phenylimino-p-benzoquinone-N-oxide