Synthesis of Spiro[2-cyclopentene-1,3’-imidazo[1,2-a]pyridine] Derivatives and Their Interesting Behavior in 1H-NMR Spectra in Deuteriochloroform
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概要
- 論文の詳細を見る
Ethyl 2’,3’-dihydro-2-methylthio-2’,4-dioxospiro[2-cyclopentene- 1,3’-imidazo[1,2-a]pyridine]-3-carboxylates were synthesized from the reactions of 3-[bis(methylthio)methylene]-2(3H)-imidazo[1,2-a]pyridinones with ethyl 4-chloroacetoacetate in the presence of a base. The 2-methylthio group in these spiro compounds was easily replaced with some primary and secondary amines to afford the corresponding 2-amino derivatives. Very interestingly, the proton signals of these spiro compounds in the ¹H-NMR spectra in deuteriochloroform (CDCl₃) changed with an increase in the sample concentration, and the analysis for the magnitude and the direction of each proton shift disclosed the conformational change of the cyclopentenone moiety in this molecule.
- 2010-09-01
著者
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Suga Hiroyuki
岡山大学 医歯総研究 麻酔蘇生学
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Suga Hiroyuki
Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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Suga H
Department Of Physiology Ii Okayama University Medical School
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Kakehi A
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Suga Hiroyuki
Department Of Systems Physiology Okayama University Graduate School Of Medicine Dentistry And Pharma
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Akikazu Kakehi
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Suga H
Department Of Systems Physiology Okayama University Graduate School Of Medicine Dentistry And Pharma
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Suga Hiroyuki
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Kakehi A
Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855
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Suga H
Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855
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Suga Hiroyuki
Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855
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Itoh Kennosuke
Shinshu Univ. Nagano Jpn
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