Preparation of New Nitrogen-Briged Heterocycles. 49. A New Access to Thieno[3,4-b]indolizine Derivatives

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概要

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• The title compounds, together with 3-vinylindolizine-1-carbonitriles (4-56%), were prepared in 1-18% yields from the S-alkylation of pyridinium 1-[3-ethoxycarbonyl-1-[cyanomethylthio(thiocarbonyl)]]allylides with alkyl halides, followed by treatment of the resulting pyridinium salts with a base and then a dehydrogenating agent. In several reactions of pyridinium salts obtained from reaction of the allylides with benzylic halides, trace amounts of bis[1-cyano-9-(ethoxycarbonyl)thieno[3,4-b]indolizin-3-yl] disulfides with an interesting superimposed structure were also isolated. The structures of these compounds were confirmed by X-ray analyses.

• 社団法人日本薬学会の論文
• 2000-06-01

著者

• Kakehi A

  Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University

• Zuo Peng

  Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University

• Akikazu Kakehi

  Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University

• Kakehi Akikazu

  Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University

• Kakehi A

  Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855

• ITO Suketaka

  Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University

• HIRATA Kazuyuki

  Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University

• Ito Suketaka

  Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University

• HIRATA Kazumi

  Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences

• Hirata K

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Ito Suketaka

  Department of Applied Chemistry Faculty of Engineering Nagoya University

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