Side Chain-Dependent Binding of Antitumor Indoloquinoxaline Derivatives to DNA:Comparative Spectroscopic and Viscometric Measurements

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概要

• 論文の詳細を見る

• NCA0424(1)and its side chain positional isomer, NCA0465(2), are indoloquinoxaline derivatives with potent antitumor activity. To investigate the effect of side chain position for binding with DNA, the interactions of 2 with various B-form DNAs were studied by spectroscopic(circular dichroism(CD), fluorescence and UV)and viscosity measurements and were compared with those of 1. The binding preference for the base sequence was different in each case. The CD spectra showed that 2 formed an asymmetric binding of indoloquinoxaline ring with adenine in DNA, whereas such a base selectivity was not found with 1. The binding features are discussed based on association constants and thermodynamic parameters, indicating the importance of the side chain position for binding specificity for DNA.

• 公益社団法人日本薬学会の論文
• 2001-01-01

著者

• 北村 和則

  富山化学工業株式会社綜合研究所

• ISHIDA Toshimasa

  Department of Pyysical Chemistry, Osaka University of Pharmaceutical Sciences

• KITAMURA Kunihiro

  Research Center of Taisho Pharmaceutical Co., Ltd.

• NAKAIKE Shiro

  Research Center of Taisho Pharmaceutical Co., Ltd.,

• Ishida T

  Osaka Univ. Pharmaceutical Sci. Osaka

• Ishida Toshimasa

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Kitamura Keisuke

  Kyoto Pharmaceutical University

• Nakaike S

  Taisho Pharmaceutical Co. Ltd. Saitama Jpn

• Ishida T

  Departments Of Biochemistry Shiga University Of Medical Science

• Kitamura K

  Kyoto Pharmaceutical University

• HIRATA Kazumi

  Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences

• ARAYA Jyunko

  Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences

• 北村 和則

  Kyoto Pharmaceutical University

• Hirata K

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Araya Jyunko

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Ishida Toshimasa

  Osaka Univ. Of Pharmaceutical Sciences

• Nakaike Shiro

  Research Center of Taisho Pharmaceutical Co., Ltd.

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