Studies on Cognitive Enhancing Agents. I. Antiamnestic and Antihypoxic Activities of 2-Dimethylaminoethyl Ethers and Related Compounds
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概要
- 論文の詳細を見る
N-(2-Dimethylaminoethyl)carboxamide (1a-d), 2-dimethylaminoethyl alkyl ether (2a, b), and 2-dimethylaminoethyl 2-hydroxy-2-phenethyl ether (3a-c) and its amino and methylene analogues (3d, 4) have been screened for antiamnestic and antihypoxic activitied in mice. A clear reversing effect on electroconvulsive shock-induced amnesia was found with 1a-d, 2a, b, and 2-dimethylaminoethyl 2-hydroxy-2-phenylethyl ether (3a). However, a protective effect against hypoxia was only observed with 3a. Compound 3a, which displayed the dual activity, was further investigated for ameliorating effect on CO_2-induced memory impairment, and it was found to be more potent than indeloxazine and bifemelane. In addition, the acute toxicity of 3a in mice was significantly lower than that of tacrine, but its serum-to-brain penetration ability in rats was less than of the reference drugs.
- 社団法人日本薬学会の論文
- 1995-09-15
著者
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小野 哲
富山化学工業株式会社綜合研究所
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成田 弘和
富山化学工業株式会社綜合研究所
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藤堂 洋三
富山化学工業株式会社綜合研究所
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田井 賢
富山化学工業株式会社綜合研究所
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小野 哲
Research Laboratories, Toyama Chemical Co., Ltd.
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山藤 哲夫
Research Laboratories, Toyama Chemical Co., Ltd.
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茶木 久晃
Research Laboratories, Toyama Chemical Co., Ltd.
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藤堂 洋三
Research Laboratories, Toyama Chemical Co., Ltd.
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前川 睦子
Research Laboratories, Toyama Chemical Co., Ltd.
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北村 和則
Research Laboratories, Toyama Chemical Co., Ltd.
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成田 弘和
Research Laboratories, Toyama Chemical Co., Ltd.
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田井 賢
Research Laboratories, Toyama Chemical Co., Ltd.,
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前川 睦子
富山化学工業株式会社綜合研究所
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北村 和則
富山化学工業株式会社綜合研究所
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茶木 久晃
Research Laboratories Toyama Chemical Co. Ltd.
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藤堂 洋三
Research Laboratories Toyama Chemical Co. Ltd.
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Narita H
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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Kitamura Keisuke
Kyoto Pharmaceutical University
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山藤 哲夫
Research Laboratories Toyama Chemical Co. Ltd.
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Ono S
Graduate School Of Pharmaceutical Sciences Hokkaido University
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