Superoxide Anion Scavenging Properties of Fluvastatin and Its Metabolites
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the in vitro superoxide anion scavenging activities of fluvastatin and its metabolites. Fluvastatin showed dose-dependent superoxide anion scavenging activity in the NADH/phenazine methosulphate (PMS)/nitroblue tetrazolium (NBT) system, and the effect was as potent as the reference antioxidant, trolox, which is a water-soluble α-tocopherol derivative. The superoxide anion scavenging activities of the major metabolites of fluvastatin (M2,M3,M4,M7) were also determined in this system. All of these metabolites showed the activity. In particular, M2 and M3,which possess a phenolic hydroxyl group at the 5 or 6-position of the indole moiety, respectively, showed 3 times stronger activities than that of fluvastatin. Further, we also determined the effects of fluvastatin, M2 and M3 on phorbol myristate acetate (PMA)-induced superoxide anion generation in human peripheral blood polymorphonuclear leukocytes (PMN). The compounds tested also showed a depressing effect on the amount of superoxide anion in this system. We suggest that fluvastatin and its metabolites have the potential to protect cells or lipids from oxidative modification mediated by superoxide anion.
- 公益社団法人日本薬学会の論文
- 1999-10-15
著者
-
Narita H
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Narita Hiroshi
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Narita Hiroshi
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd
-
YASUHARA Mikiko
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
SUZUMURA Kuniharu
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
Yasuhara M
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Suzumura Kuniharu
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Suzumura Kuniharu
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd
-
Narita Hiroshi
Discovery Research Laboratories Tanabe Seiyaku Co. Ltd.
-
Suzumura Kuniharu
Faculty Of Pharmaceutical Sciences Chiba University
関連論文
- A New Cognition-Enhancing Agent, (R)-(-)-1-(Benzo [b] thiophen-5-yl)-2-[2-(N, N-diethylamino) ethoxy] ethanol Hydrochloride. Effects on Memory Impairment in Rats Generated by Cerebral Embolization and Basal Forebrain Lesions
- Studies on Cognitive Enhancing Agents. III・ Antiamnestic and Antihypoxic Activities of a Series of 1-Bicycloaryl-2-(ω-aminoalkoxy)ethanols
- Studies on Cognitive Enhancing Agents. II. Antiamnestic and Antihypoxic Activities of 1-Aryl-2-(2-aminoethoxy)ethanols
- Studies on Cognitive Enhancing Agents. I. Antiamnestic and Antihypoxic Activities of 2-Dimethylaminoethyl Ethers and Related Compounds
- ^C標識 pazufloxacin 注射薬のラットおよびマウスにおける体内動態
- Pazufloxacin 注射薬の動物およびヒトにおける代謝
- (-)-(S)-10-(1-Aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic Acid(T-3761)の水溶液中及び固体状態における光分解物の構造について
- Effects of Fluvastatin and Its Major Metabolites on Low-Density Lipoprotein Oxidation and Cholesterol Esterification in Macrophages
- Fluvastatin, an HMG-CoA Reductase Inhibitor, Protects LDL from Oxidative Modification in Hypercholesterolemic Rabbits
- In Vitro Inhibitory Effects of the Optical Isomers and Metabolites of Fluvastatin on Copper Ion-Induced LDL Oxidation
- An in Vitro Study of the Hydroxyl Radical Scavengin Property of Fluvastatin, and HMG-CoA Reductase Inhibitor
- Inhibitory Effects of Fluvastatin and Its Metabolites on Hydrogen Peroxide-Induced Oxidative Destruction of Hemin and Low-Density Lipoprotein
- Focal Cerebral Ischemia-Induced Escape Deficit in Rats Is Ameliorated by a Reversible Inhibitor of Monoamine Oxidase-A : Implications for a Novel Animal Model of Post-Stroke Depression
- Possible Therapeutic Effect of T-794,a Novel Reversible Inhibitor of Monoamine Oxidase-A, on Post-Stroke Emotional Disturbances, Assessed in Animal Models of Depression
- Protective Effect of TA-993, a Novel Therapeutic Agent for Peripheral Circulatory Insufficiency, on Skeletal Muscle Fatigue in a Rat Model of Hindlimb Ischemia
- Food Deprivation Depletes Gastric Mucus Glycoprotein in Streptozotocin-Induced Diabetic Rats
- Usefulness and Limitation of DiBAC_4(3), a Voltage-Sensitive Fluorescent Dye, for the Measurement of Membrane Potentials Regulated by Recombinant Large Conductance Ca^-Activated K^+ Channels in HEK293 Cells
- Superoxide Anion Scavenging Properties of Fluvastatin and Its Metabolites
- A Novel Na^+ and Ca^ Channel Blocker, T-477, Prevents Brain Edema Following Microsphere-Induced Permanent Occlusion of Cerebral Arterioles in Rats
- Time-Dependent Changes in the Ischemic Forebrain Following the Microsphere-Induced Permanent Occlusion of Cerebral Arterioles in Rats
- Comparative Study of TA-606, a Novel Angiotensin II Receptor Antagonist, With Losartan in Terms of Species Difference and Orthostatic Hypotension
- Pharmacologically Active Components of Viticis Fructus (Vitex rotundifolia). : I. The Components Having Vascular Relaxation Effects
- Portective Action of Angiotensin Converting Enzyme Inhibitors on Cardiac Hypertrophy in the Aortic-Banded Rat.