Time-Dependent Changes in the Ischemic Forebrain Following the Microsphere-Induced Permanent Occlusion of Cerebral Arterioles in Rats
スポンサーリンク
概要
- 論文の詳細を見る
To evaluate the progression of brain edema without modification by the effect of anesthetics, we examined the local and permanent ischemia model in unanesthetized rats. The forebrain embolism was induced by intra-arterial infusion of microspheres of 50-μm diameter in freely moving rats. From 2 to 48 hr following the injection, the water-, Na- and Ca-contents progressively increased while the K content decreased in the microsphere-injected hemisphere. After the 3rd day, the water- and Na-contents gradually decreased and returned to the normal level on the 14th day. In contrast, the Ca level remained elevated even on the 56th day. The animals showed signs of neurological deficits 24 hr after the injection. In histopathological examination, large infarct areas were present in the microsphere-injected hemisphere after 24 to 48 hr. One to two weeks later, the lateral ventricle was expanded. Eight weeks after the injection, the ventricle remained expanded and newly developed infarct areas were observed in a scattered pattern around the fibrotic area. The results show the close correlation between the development of edema and the increase/decrease of Na/K contents from the onset to the recovery from edema, and their changes are similar to those in human stroke. This model enables us to evaluate not only the acute ischemic insult but also the chronic changes of the forebrain following the stroke.
- 社団法人 日本薬理学会の論文
著者
-
KUDO Yukitsuka
Tohoku University Biomedical Engineering Research Organization (TUBERO)
-
Narita Hiroshi
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd
-
Narita Hirokazu
Research Laboratories Toyama Chemical Co. Ltd
-
Kikuchi S
Department Of Molecular And Cellular Pharmacology National Children's Medical Research Center
-
Narita H
Research Laboratories Toyama Chemical Co. Ltd
-
Kudo Yukitsuka
Department Of Neuroimaging Research Innovation Of New Biomedical Engineering Center Tohoku Universit
-
Kudo Yukitsuka
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
-
OKAMOTO Masahito
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.,
-
Okuyama Kayoko
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
-
IWASAKI Hitoshi
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
KIUCHI Satoko
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
Okamoto Masahito
Sales & Marketing Division Mitsubishi Tanabe Pharma Corporation
-
Iwasaki Hitoshi
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Narita Hiroshi
Discovery Research Laboratories Tanabe Seiyaku Co. Ltd.
関連論文
- Binding and safety profile of novel benzoxazole derivative for in vivo imaging of amyloid deposits in Alzheimer's disease
- Lithium therapy and cerebrospinal fluid biomarker levels in Alzheimer's disease
- Long-Lasting Anti-emetic Effect of T-2328, a Novel NK_1 Antagonist
- Pharmacological Characterization of T-2328, 2-Fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile Dihydrochloride, as a Brain-Penetrating Antagonist of Tachykinin NK_1 Receptor
- Effects of Fluvastatin and Its Major Metabolites on Low-Density Lipoprotein Oxidation and Cholesterol Esterification in Macrophages
- Fluvastatin, an HMG-CoA Reductase Inhibitor, Protects LDL from Oxidative Modification in Hypercholesterolemic Rabbits
- In Vitro Inhibitory Effects of the Optical Isomers and Metabolites of Fluvastatin on Copper Ion-Induced LDL Oxidation
- Inhibitory Effects of Fluvastatin and Its Metabolites on Hydrogen Peroxide-Induced Oxidative Destruction of Hemin and Low-Density Lipoprotein
- Focal Cerebral Ischemia-Induced Escape Deficit in Rats Is Ameliorated by a Reversible Inhibitor of Monoamine Oxidase-A : Implications for a Novel Animal Model of Post-Stroke Depression
- Stimulation of Noradrenaline Release by T-588, a Cognitive Enhancer, in PC12 Cells
- The Effects of T-588, a Novel Cognitive Enhancer, on Noradrenaline Uptake and Release in Rat Cerebral Cortical Slices
- Geriatric Medicine, Japanese Alzheimer's Disease Neuroimaging Initiative and Biomarker Development
- In vivo labeling of amyloid with BF-108
- A novel nonsense mutation of the PEPD gene in a Japanese patient with prolidase deficiency
- Structure and Sequence of the Mouse V1a and V1b Vasopressin Receptor Genes
- Protective Effect of TA-993, a Novel Therapeutic Agent for Peripheral Circulatory Insufficiency, on Skeletal Muscle Fatigue in a Rat Model of Hindlimb Ischemia
- A Novel Angiotensin II-Receptor Antagonist, 606A, Induces Regression of Cardiac Hypertrophy, Augments Endothelium-Dependent Relaxation and Improves Renal Function in Stroke-Prone Spontaneously Hypertensive Rats
- Food Deprivation Depletes Gastric Mucus Glycoprotein in Streptozotocin-Induced Diabetic Rats
- Repeated Injections of Nicergoline Increase the Nerve Growth Factor Level in the Aged Rat Brain.
- Repeated Injections of Nicergoline Increase the Nerve Growth Factor Level in the Aged Rat Brain
- Usefulness and Limitation of DiBAC_4(3), a Voltage-Sensitive Fluorescent Dye, for the Measurement of Membrane Potentials Regulated by Recombinant Large Conductance Ca^-Activated K^+ Channels in HEK293 Cells
- Superoxide Anion Scavenging Properties of Fluvastatin and Its Metabolites
- A Case of Renal Mesenchymal Tumor in a Young Beagle Dog
- A Novel Na^+ and Ca^ Channel Blocker, T-477, Prevents Brain Edema Following Microsphere-Induced Permanent Occlusion of Cerebral Arterioles in Rats
- Time-Dependent Changes in the Ischemic Forebrain Following the Microsphere-Induced Permanent Occlusion of Cerebral Arterioles in Rats
- Comparative Study of TA-606, a Novel Angiotensin II Receptor Antagonist, With Losartan in Terms of Species Difference and Orthostatic Hypotension
- A modified method of 3D-SSP analysis for amyloid PET imaging using [^C]BF-227
- Portective Action of Angiotensin Converting Enzyme Inhibitors on Cardiac Hypertrophy in the Aortic-Banded Rat.