Repeated Injections of Nicergoline Increase the Nerve Growth Factor Level in the Aged Rat Brain
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概要
- 論文の詳細を見る
We studied whether nicergoline, clinically active in chronic cerebrovascular insufficiency, influences nerve growth factor (NGF) levels in the rat brain. In young Fischer rats, repeated intraperitoneal injections of nicergoline (0.3 and 1.0 mg/kg body weight) did not show any effects on frontal NGF contents determined by a highly sensitive enzyme immunoassay. In aged rats, 22-month-old, however, repeated injections of nicergoline (1.0 mg/kg body weight) induced a significant increase in the NGF level in the frontal region.
- 社団法人 日本薬理学会の論文
著者
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KUDO Yukitsuka
Tohoku University Biomedical Engineering Research Organization (TUBERO)
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KUDO Yukitsuka
Department of Biomedical Engineering Research Organization, Tohoku University Graduate School of Med
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AKIGUCHI Ichiro
Department of Neurology, Graduate School of Medicine, Kyoto University
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SUNOHARA Nobuhiko
Department of Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, Nation
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Furukawa Shoei
Department Of Molecular Biology Gifu Pharmaceutical University
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Kudo Yukitsuka
Department Of Neuroimaging Research Innovation Of New Biomedical Engineering Center Tohoku Universit
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Akiguchi Ichiro
Department Of Gerontology Faculty Of Medicine Kyoto University Kyoto Japan
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NISHIO TAKESHI
Department of Gastroenterology and Hepatology, Kinki University School of Medicine
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Nishio Takeshi
Department Of Gastroenterology And Hepatology Kinki University School Of Medicine
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Sunohara Nobuhiko
Department Of Neurology National Center Hospital For Mental Nervous And Muscular Disorders National
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