Amyotrophic lateral sclerosis with IgM antibody against gangliosides GM2 and GD2
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概要
- 論文の詳細を見る
We report a case of amyotrophic lateral sclerosis (ALS) with IgM antibody against gangliosides GM2 and GD2. A 57-year-old woman presented with slowly progressive muscular weakness of the upper extremities and dysarthria. She fulfilled the clinical and electrophysiological criteria of ALS, and died from sudden suffocation about 3 years after the onset of illness. The patients serum IgM antibody was shown to recognize the structure shared by GM2 and GD2. Since anti-GM2 antibodies have been implicated in motor neuropathy or motor neuron syndrome, this rare case might contribute to the understanding of the immunological aspects of ALS.(Internal Medicine 42: 277-280, 2003)
- 社団法人 日本内科学会の論文
- 2003-03-01
著者
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Kusunoki Susumu
Department Of Neurology Graduate School Of Medicine University Of Tokyo
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Satoi Hitoshi
Department Of Neurology N.h.o. Minami-kyoto National Hospital
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Shibasaki Hiroshi
Department Of Brain Pathophysiology Human Brain Research Center Kyoto University School Of Medicine
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Kanda Masutaro
Division Of Neurology Takeda General Hospital
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Akiguchi Ichiro
Department Of Gerontology Faculty Of Medicine Kyoto University Kyoto Japan
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OKA Nobuyuki
Division of Neurology, Department of Internal Medicine, Hyogo College of Medicine
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Akiguchi Ichiro
Department Of Neurology Kyoto University Graduate School Of Medicine
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Mizutani Kotaro
Department Of Neurology Sakakibara Hakuho Hospital
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Kaji Ryuji
Department Of Clinical Neuroscience Tokushima University Hospital
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Kaji Ryuji
Department Of Clinical Neuroscience Institute Of Health Biosciences The University Of Tokushima Graduate School
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Kaji R
Department of Clinical Neuroscience, Tokushima University Hospital
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Kanda M
Division of Neurology, Takeda General Hospital
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Akiguchi I
Department of Neurology, Kyoto University Graduate School of Medicine
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Shibasaki H
Department of Neurology, Kyoto University Graduate School of Medicine
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