Further Studies on the Mechanisms of Stroke in Stroke-Prone SHR:Decrease in Regional Cerebral Blood Flow and Catecholamine Depletion
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概要
- 論文の詳細を見る
Chronic rCBF reduction under severe hypertensive state preceded the development of vascular damages in SHRSP, and by controlling blood pressure under 200mmHg rCBF was maintained well within normal range so that no stroke was observed. Noradrenaline fluorescence was reduced in cerebral lesions which developed spontaneously in SHRSP. When rCBF was reduced in young SHRSP acutely after the bilateral ligation of carotid arteries, depletion of noradrenaline and dopamine was noted. From this observation catecholamines seem to be released when nerve terminals are exposed to hypoxia. It may be possible that released catecholamines accelerate the vasoconstriction of cerebral arteries and further decrease the blood supply to the areas, thus to increase vascular permeability which results in arterionecrosis and/or thrombus formation. Thus, catecholamines might be involved in the vicious circle for inducing cerebrovascular lesions.
- International Heart Journal刊行会の論文
著者
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Yamori Yukio
Japan Stroke Prevention Center And Department Of Pathology Shimane Medical University
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Nara Yasuo
Japan Stroke Prevention Center And Department Of Pathology Shimane Medical University
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Akiguchi Ichiro
Department Of Gerontology Faculty Of Medicine Kyoto University Kyoto Japan
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Horie Ryoichi
Japan Stroke Prevention Center
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OHTAKA Michiya
Japan Stroke Prevention Center
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HANDA Hajime
Japan Stroke Prevention Center
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