Neural Mechanism of Cerebrovascular Atherogenesis in Rats
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概要
- 論文の詳細を見る
As previously reported (Yamori et al: Jap Heart J 18: 544, 1977) a substrain (A3) of SHRSP developed no cerebrovascular fat deposition under hypertensive condition when bilateral cervical sympathectomy was performed, and a role of neural vascular control in cerebrovascular atherogenesis was suspected by the fluorescence microscopic study which clarified the morphological features, meshwork or ring-like distribution of the cerebrovascular innervation.In the present study, for further analysis, the effects of denervation on athero-genesis in the cerebrovascular system of normotensive WK with bilateral carotid arteries ligated was investigated. The denervated group revealed siggnficantly lower susceptibility than the control group. Blood pressure, serum cholesterol level, and gain in body weight showed no significant differences between them. Further, fluorescence microscopic study using Evans blue confirmed the coincidence of the richly innervated vascular segments with increased permeability in the vascular wall.On the other hand, the present study has proven a difference in the effects of denervation on atherogenesis in the cerebrovascular system in various strains of SHRSP. Denervation was the most effective in A3 strain and the least effective in A1-sb. The effect in A4 strain was intermediate between those in A3 and A1-sb. This experimental fact is noteworthy, because A4 substrain was obtained by crossing between A3 and A1-sb substrains.Furthermore, fluorescence microscopic study of the basilar arteries in SHRSP and WK showed the difference in quality of NA terminal or varicosity between SHRSP and WK, i.e., SHRSP revealed larger NA varicosity. This observation suggested high responsiveness of the densely innervated vascular wall in SHRSP. These results reaffirmed the important role of neural control in cerebrovascular atherogenesis and suggested the involvement of a genetic factor, which is partly due to a difference in neural vascular control.
- International Heart Journal刊行会の論文
著者
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Yamori Yukio
Japan Stroke Prevention Center And Department Of Pathology Shimane Medical University
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HORIE RYOICHI
Japan Stroke Prevention Center. Izumo,Department of Neurosurgery Faculty of Medlcme Kyoto Unversity
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OHTAKA MICHIYA
Japan Stroke Prevention Center. Izumo,Department of Neurosurgery Faculty of Medlcme Kyoto Unversity
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Akiguchi Ichiro
Japan Stroke Prevention Center
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Ooshima Akira
Japan Stroke Prevention Center
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OHTA Kiyoe
Japan Stroke Prevention Center
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Horie Ryoichi
Japan Stroke Prevention Center
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OHTAKA Michiya
Japan Stroke Prevention Center
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Yamori Yukio
Japan Stroke Prevention Center
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