Regional Cerebral Blood Flow (rCBF) in Stroke-prone SHR (SHRSP) Treated with β-Blocker (Propranol)

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In the present study, it became clear that β-blocker (propranorol) had effectively improved rCBF in adult SHRSP with sever hypertension in which rCBF was significantly lower than control WKY. Yamori and Horie's previous studies clarified the BP reduction in SHRSP with severe hypertension increased rCBF and prevented the development of cerebrovascular lesions (STROKE 8: 456, 1977). It is noteworthy that β-blocker, without reducing BP significantly in SHRSP with severe hypertension, increases rCBF significantly. Because of the high frequency of pulse rate over 400/min in conscious rats, blood flow in cerebral arteries near recurrent branchings is regarded as being nearly similar to steady flow. Since our previous hemorheological study demonstrated that pulsatile flow increased flow into recurrent branches and that the effect of pulsation was augmented with the increased pulse pressure (Niimi et al: JAP HEART J 20: 681, 1979), it is theoretically considered that β-blocker, which reduces heart rate without affecting BP and thereby increases pulse pressure, favourably increases the reduced blood flow into recurrent arteries especially under severe hypertension. The present experiment substantiated this hypothesis and suggested that β-blocker, even without reducing blood pressure markedly, would be useful for preventing cerebrovascular lesions caused by hypoxia due to reduced rCBF in the predilection sites of stroke fed by recurrent arteries.
International Heart Journal刊行会の論文

Regional Cerebral Blood Flow (rCBF) in Stroke-prone SHR (SHRSP) Treated with β-Blocker (Propranol)

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