Relationship between Arterial Lesions of the Retina and the Brain in Stroke-prone SHR (SHRSP)

概要

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Retinal arterioles never showed sudanophilic rings while the cerebral and mesentric arteries and arterioles rapidly developed clear ring-like fat diposition. (1) Further, it was noteworthy that, in the present study, the precise correlation in "organic" lesions between retinal and cerebral vascular systems was not exactly confirmed. These results suggested a probable difference in the hypertensive involvement of these vascular systems, and substantiated the important role of neural mechanism in the arterial fat deposition, which was a good indicator for the detection of increased vascular permeability, as reported by Horie et al (Jap Heart J 19: 1978). The difference in the innervation of these vessels may be partly responsible for specific susceptibility to arterial lesions, because denervation by superior cervical sympathectomy ameliorated cerebrovascular atherogenesis (Yamori et al: Jap Heart J 18: 544, 1977).
International Heart Journal刊行会の論文