Hypophyseal Function in SHR:Lysine Incorporation and ACTH Content
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概要
- 論文の詳細を見る
Pituitary weights were already increased in SHR at the young stage (8weeks of age) compared with WK. The weights of anterior lobes were also increased at the age of 4 months. This increase in weight appeared to have a functional significance as proved by the increased 3H-lysine incorporation into the pituitary. As the prevention of the development of hypertension by apresoline treatment or by splanchnicotomy had no effect on the increased lysine-incorporation, the acceleration of such a metabolism did not seem to be the secondary phenomenon to hypertension, but was supposed to be a primary alteration in SHR. ACTH content in the pituitary was increased in pretreatment of dexamethasone, ACTH content was rather decreased in SHR. 4-month-old SHRSP compared with the age-matched WK. After the acute pretreatment of dexamethasone, ACTH content was rather decreased in SHR. This finding suggested one possibility that dexamethasone did not efficiently block ACTH secretion from the pituitary in SHR.
- International Heart Journal刊行会の論文
著者
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Sato Masayasu
Department Of Fusion Plasma Research Naka Fusion Research Establishment Japan Atomic Energy Research
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Horie Ryoichi
Department Of Hematology Faculty Of Medicine Kitasato University
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Horie Ryoichi
Department of Neurosurgery, Faculty of Medicine, Kyoto University
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Ohta Kiyoe
Department of Neurosurgeruy, Faculty of Medicine, Kyoto University
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Yamori Yukio
Department of Life Science, Graduate School of Human and Environmental, Kyoto University
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HORIE Ryoichi
Department of and Neurosurgery, Kyoto University
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