Pathogenesis of Acute Arterial Fat Deposition in Spontaneously Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
The selectively-bred substrains of spontaneously hypertensive rats with a greater vulnerability to vascular lesions rapidly developed arterial fat deposition within 1 or 2 weeks as well as a greater hypercholesterolemics response when fed on high fat cholesterol diet including 20% of suet, 5% of cholesterol and 2% of cholic acid. The ring-like arterial fat deposition at the branches of superior mesenteric arteries and cerebrobasal arteries, which was found to be good indices for the deposition of intrarenal or coronary arteries, was not observed in normotensive rats fed on high fat cholesterol diet for 3 months, greatly delayed in SHR under antihypertensive treatment and accelerated by 1% salt loading in drinking water. The horseradish peroxidase infused intravenously 1 to 4 hours before sacrifice leaked in ring-like forms which corresponded to the fat deposit in mesenteric arteries. The incorporation of ^3H-proline infused 4 hours before sacrifice was enhanced in the mesenteric arteries with the fat deposition. These results clearly indicated that hypertension was a great contributory factor to rapid arterial fat deposition, which was caused by an increased vascular permeability and enhanced the arterial collagen formation, the initiation process of arterio- or atherosclerosis.
- 社団法人日本循環器学会の論文
- 1975-06-20
著者
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Hamashima Yoshihiro
Department Of Biomaterials Institute For Frontier Medical Sciences Kyoto University
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Yamori Yukio
Department Of Pathology Faculty Of Medicine Kyoto University
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Horie Ryoichi
Department of Pathology, Shimane Medical University
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SATO Masayasu
Department of Radiology, Keio University School of Medicine
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Sato Masayasu
Department Of Fusion Plasma Research Naka Fusion Research Establishment Japan Atomic Energy Research
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Horie Ryoichi
Department Of Hematology Faculty Of Medicine Kitasato University
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Horie Ryoichi
Department Of Neurosurgery Faculty Of Medicine Kyoto University
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HANDA HAZIME
Department of Neurosurgery, Faculty of Medicine, Kyoto University
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Handa Hazime
Department Of Neurosurgery Faculty Of Medicine Kyoto University
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Sato Masayasu
Department Of Psychiatry Faculty Of Medicine Kyoto University
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Yamori Yukio
Department of Pathology, Faculty of Medicine, Kyoto University
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Yamori Yukio
Department of Life Science, Graduate School of Human and Environmental, Kyoto University
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HORIE Ryoichi
Department of and Neurosurgery, Kyoto University
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