STUDY OF THE PATHOGENESIS OF CARDIAC HYPERTROPHY : Biochemical Differences of Cultured Heart Cells from Normotensive and Spontaneously Hypertensive Rats
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概要
- 論文の詳細を見る
To elucidate the metabolic properties of the heart of spontaneously hypertensive rats (SHR), we examined the uptakes of ^3H-uridine (3H)and ^<14>C-leucine (14C) into single cultured heart cells, as well as the total protein content and cell size of heart cells in the presence and absence of stimulation, and compared the findings with those obtained with Wistar Kyoto rat (WKY) cells. As a result, (1) Spontaneous uptakes of 3H and 14C into WKY heart cells increased rapidly from day 2 to days 5-6, and then decreased gradually. In contrast, in SHR heart cells a constant increase in the uptakes of 3H and 14C was observed until the 10th day. The uptakes of both 3H and 14C into 10-day-old SHR heart cells were significantly higher than those into WKY heart cells (p<0.05). (2) The total protein content of SHR heart cells cultured for 4 or 5 days was significantly less than that of WKY heart cells, but there was no significant difference between cells cultured for more than 6 days. As for cell size, no significant difference was observed regardless of how long the cells were cultured. However, the increment in SHR heart cell total protein and cell size during cultivation appeared to be higher than they were in WKY heart cells. (3) Stimulation of heart cells with 10^<-8>-10^<-5> M L(-)-isoproterenol (ISO) for 1 hour increased the uptake of 3H into heart cells from both kinds of rats, with no significant difference between the two. In contrast, after 3-hour stimulation uptake of 3H into WKY heart cells was lower than it was after a 1-hour stimulation, while that in SHR heart cells increased. Angiotensin II (AngII) also increased the uptake of 3H into both types of heart cells, the responsiveness to various concentrations of AngII showing no significant differences. Our results showed that SHR heart cells in vitro had an increased spontaneous metabolic rate and an increased responsiveness to ISO, confirming previous in vivo results and suggesting that these metabolic properties play a role in cardiac hypertrophy in SHR.
- 社団法人日本循環器学会の論文
- 1989-10-20
著者
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Morioka Shigefumi
Department of Cardiology, Kobe City Medical Center General Hospital
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Honda Masaaki
Department of Computer Engineering, Waseda University
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Yamada Sachiko
The 4th Department Of Internal Medicine Shimane Medical University
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Yamori Y
Institute For World Health Development Mukogawa Women's University
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Yamori Y
Who Centre For Primary Prevention Of Cardiovascular Diseases Kyoto Jpn
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Yamori Yukio
福山大学 衛生化学
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Yamori Yukio
Department Of Pathology Faculty Of Medicine Kyoto University
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HONDA MASAAKI
The 4th Department of Internal Medicine, Shimane Medical University
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OHOKA MICHIKUNI
Department of Pathology Shimane Medical University
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MORIYAMA KATSUTOSHI
Department of Internal Medicine
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YAMADA SACHIKO
Department of Internal Medicine, Shimane Medical University
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Yamori Yukio
Who Collaborating Center
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Honda Masaaki
The 4th Department Of Internal Medicine Shimane Medical University
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Morioka Shigefumi
Fourth Department Of Internal Medicine Shimane Medical University
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Moriyama Katsutoshi
The Fourth Department Of Internal Medicine Shimane University
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Yamori Yukio
Departments Of Pathology Shimane Medical University
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Morioka Shigefumi
Department Of Cardiology Kobe City Medical Center General Hospital
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Yamada Sachiko
Department Of Biomolecular Science Faculty Of Science University Of Toho
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Honda Masaaki
Department Of Computer Engineering Waseda University
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Yamori Yukio
Department of Life Science, Graduate School of Human and Environmental, Kyoto University
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Honda Masaaki
Department of Chemistry, Faculty of Science, Kumamoto University
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